National guidelines have been developed for clinicians on the use of genomics to diagnose and care for patients with monogenic inflammatory bowel disease (IBD), a group of intestinal disorders caused by variations in a single gene. The new guidelines, unveiled in an article in the Lancet ... READ MORE
Better diagnosis and treatment of autoimmune diseases a step closer
A study involving Oxford researchers has outlined a way to find the crucial peptides (protein fragments) that drive autoimmunity, as well as the immune cells that respond to it. On a fundamental level, in autoimmune diseases immune cells mistake healthy cells for infected cells. Finding the ... READ MORE
Professor Marian Knight recognised for services to maternal and public health
Professor Marian Knight, the Oxford Biomedical Research Centre’s Co- Theme Lead for Cardiovascular Medicine, has been recognised in the New Year Honours list 2023. She was appointed Member of the Order of the British Empire (MBE) for services to Maternal and Public Health. Professor ... READ MORE
Genetic ‘marker’ linked to side-effects from skin cancer treatment found
New research has identified a genetic marker that could be used to predict a patient’s risk of developing serious side-effects when undergoing immunotherapy treatment for one of the most common skin cancers. The study, which was supported by the NIHR Oxford Biomedical Research Centre ... READ MORE
No benefit found in switching to citrate anticoagulation for ICU kidney injury treatment
New research has found no added benefit of using citrate-based drugs in the treatment of acute kidney disease in intensive care, when compared to the anticoagulation drug heparin, despite their extra cost. People with acute kidney injury (when the kidneys stop working correctly) may need a ... READ MORE
Adalimumab found to be cost-effective treatment for early-stage Dupuytren’s disease
Oxford researchers supported by the Oxford BRC have found that the anti-TNF treatment adalimumab is likely to be a cost-effective treatment for people affected by early-stage Dupuytren’s disease. Anti-TNF treatments interfere with the action of a protein called tumour necrosis factor (TNF) and ... READ MORE
Patient and public involvement contributors prepare for launch of new BRCs
Patient and public contributors have gathered with researchers in Oxford to discuss how patient and public involvement and engagement (PPIE) can be enhanced and play a bigger role in the new NIHR Biomedical Research Centres (BRC) when they begin next month. The workshop at St Catherine’s ... READ MORE
Oxford researcher investigates genetic mechanisms of rare forms of asthma
An Oxford researcher has been awarded funding to expand her cutting edge research into the genetic mechanisms of rare and severe forms of asthma. Dr Anastasia Fries, NIHR Academic Clinical Fellow in Respiratory Medicine, was awarded a three-year MRC Clinical Research Training Fellowship worth ... READ MORE
BRC sponsors Black History Month talk by anti-apartheid veteran
The Oxford Biomedical Research Centre has sponsored a talk organised a talk by Oxford University Hospitals BAME network as part of Black History Month. The talk on Wednesday 12 October was by Chris Lubbe, anti-apartheid activist and former bodyguard of the late South African President Nelson ... READ MORE
Oxford researchers to study why asthma is worse in women
A University of Oxford team has been awarded a grant to study one of the major unsolved questions about asthma – why women are more likely to have it than men and why they are twice as likely to die from it. Bioinformatician Dr Emanuele Marchi has received £98,000 from the national charity ... READ MORE
New computational technique reveals changes to lung function after COVID-19 infection
A study led by Oxford researchers has found that prior COVID-19 infection is associated with more uneven inflation of the lungs during normal breathing. There was also an association between hospitalisation with COVID-19 and smaller lung volumes, and admission to the intensive care unit (ICU) was ... READ MORE
One in eight people have undiagnosed nighttime hypertension
Around 15 percent of people aged between 40 and 75 may have a form of undiagnosed high blood pressure (hypertension) that occurs only at nighttime. Because they do not know about this, and are therefore not being treated for it, they are at a higher risk of cardiovascular disease such as ... READ MORE
Next generation of research leaders complete BRC programme
Aspiring healthcare research leaders have successfully completed the latest Oxford BRC Next Generation Leaders Programme, with the 16 course participants presenting the quality improvement projects they had been working on. This is the third edition of the Next Generation Leaders Programme, ... READ MORE
Malaria booster vaccine continues to meet WHO efficacy goal
Researchers from the University of Oxford and their partners have reported new findings from their Phase 2b trial which tested the effectiveness of a booster dose of their candidate malaria vaccine. The vaccine, R21/Matrix-M, had previously demonstrated high-level efficacy of 77 ... READ MORE
OUH clinical staff awarded funding for research skills training
OUH clinical staff awarded funding for research skills training Thirteen Oxford University Hospitals (OUH) nurses, midwives, allied health professionals and research practitioners have received funding to develop skills that will support them to research new and improved ways of delivering ... READ MORE
OUH nurse researcher gets award to further study
A Clinical Academic Nurse Researcher at Oxford University Hospitals (OUH) has been given an award by the British Federation of Women Graduates (BFWG) to continue her research exploring how to improve the escalation of care for patients whose condition deteriorates in the hospital setting. Jody ... READ MORE
Study raises hope of pre-school type 1 diabetes screening programme
Researchers in Oxford have launched the first UK study in the general population to test for early markers of type 1 diabetes before children develop symptoms or need insulin. The study, which is being offered when children have their pre-school vaccination, involves a finger prick and a few ... READ MORE
Study develops radiotranscriptomic AI analysis to enable virtual heart biopsies
Oxford University researchers have found a new way of directly quantifying vascular inflammation in COVID-19 patients, in a study that could pave the way to more efficient trials of new treatments and identify patients who might be at risk of long-term complications. The study, which was ... READ MORE
Higher risk of blood clots in COVID-19 outpatients, largely reduced after vaccination
Researchers supported by the NIHR Oxford Biomedical Research Centre (BRC) have studied the link between people diagnosed with COVID-19 as outpatients and the short-term risk of developing blood clots, and the clinical and genetic risk factors that predispose them to developing post–COVID-19 ... READ MORE
Environmental impact of 57,000 multi-ingredient processed foods revealed for first time
New analysis provides a first step towards enabling consumers, retailers, and policymakers to make informed decisions on the environmental impacts of multi-ingredient food and drink products. Recent surveys indicate that over half of UK consumers want to make their diets more sustainable, and ... READ MORE
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