Lizzie Stafford, a Clinical Research Nurse Manager in the Nuffield Department of Medicine, has been involved in number of Oxford BRC-supported research studies. The BRC is funding the second year of her NIHR postgraduate clinical research programme. “I’ve been involved in some ground-breaking ... READ MORE
Blood clots during COVID-19 may cause ongoing cognitive problems
High levels of two proteins at the time of COVID-19 have been found in patients who later experienced cognitive problems, including ‘brain fog'. The findings give a major clue as to one cause of their symptoms: blood clots. Researchers from the University of Oxford looked at blood tests from ... READ MORE
New Pharmacy Clinical Trials Unit paves way for trialling new therapies
Oxford University Hospitals’ (OUH) ability to help develop ground-breaking new therapies has been given a boost with the opening of a new temporary Pharmacy Clinical Trials Unit (CTU). Based on the Churchill Hospital site, the facility will be used to handle and prepare a new range of medicines ... READ MORE
Tumour monocyte content can predict immunochemotherapy outcomes, study shows
A team of Oxford researchers has discovered a link between immune cells known as monocytes in tumours and overall survival in patients with oesophageal cancer. A study by Ludwig Cancer Research, supported by the NIHR Oxford Biomedical Research Centre (BRC) found that the presence of relatively ... READ MORE
Research profile: Clinical nurses helping to shape our medical knowledge
Yuhan Zhang is an Advanced Nurse Practitioner in Oxford University Hospitals’ Ambulatory Outreach Team. She is also in the second year of a nursing doctorate at Oxford Brookes University, for which she is getting support from the NIHR Oxford Biomedical Research Centre (BRC). Yuhan works in an ... READ MORE
Real-world vaccine response in patients with impaired immune systems revealed
Updated data from the ongoing OCTAVE study reveal, for the first time, the real-world vaccine responses and infection outcomes in clinically at-risk patients with a range of immunocompromised or immunosuppressed conditions. Preliminary data from the landmark OCTAVE study in August 2021 showed ... READ MORE
Rapid weight loss found to be safe and helpful for people with liver disease
A clinical trial has shown that a three-month rapid weight loss programme was not only safe but also effective in reducing the severity of a liver disease called non-alcoholic steatohepatitis (NASH) with liver fibrosis. Results of the trial, which showed that improvements were maintained beyond ... READ MORE
OUH receives £3.4m for cutting-edge research equipment
Oxford University Hospitals (OUH) has received £3.4 million to fund state-of-the-art research equipment that will enable scientific discoveries and new technologies to improve the prevention, management and treatment of disease. The funding was part of the £96 million awarded by the National ... READ MORE
New imaging method trialled for retinal diseases
Clinical scientists in Oxford have presented a new method of imaging of the retina that overcomes many of the drawbacks of the current standard way of diagnosing and monitoring retinal diseases like age-related macular degeneration (AMD). The study, whose findings were published in the journal ... READ MORE
New antibiotic bone cement found not to reduce infection after hip fracture surgery
A large study has found that using high-dose dual-antibiotic loaded cement is unlikely to reduce the risk of infection in people who have had hip replacement surgery for their hip fracture. Bone cement is commonly used to fix surgical implants to the patient’s bone during hip replacement. In ... READ MORE
Shoulder replacement patients fare better with surgeons who do more operations
Patients treated by surgeons who average more than 10 shoulder replacements a year have a lower risk of further operations and serious complications, and a shorter hospital stay than those treated by surgeons who do fewer operations, according to a study by Oxford researchers. These findings, ... READ MORE
New programme to move potential MND drugs into clinical trials faster
A ground-breaking experimental medicine programme that will enable researchers to more rapidly screen potential drugs in people with motor neurone disease (MND, also known as ALS), has been announced on Global MND Awareness Day. The EXPErimental medicine Route To Success, or EXPERTS-ALS programme ... READ MORE
Researchers from different BRC themes discuss CRISPR gene editing
The NIHR Oxford BRC’s Gene and Cell Therapy Theme has organised a workshop to discuss how researchers from a range of disciplines are using new CRISPR gene editing tools or applying CRISPR to their research in innovative ways. The workshop, held on 20 June at Merton College in Oxford, attracted ... READ MORE
Women diagnosed with early breast cancer less likely to die from disease than 20 years ago
A study conducted by researchers at Oxford Population Health has found that women who are diagnosed with early-stage breast cancer today are 66 percent less likely to die from the disease within five years of diagnosis than they were 20 years ago. The study, which was funded by Cancer Research ... READ MORE
Beacon Therapeutics launched to develop new generation of gene therapies for retinal diseases
A new ophthalmic gene therapy company, which aims to restore and improve the vision of patients with retinal diseases, has been launched. Beacon Therapeutics will develop a new generation of gene therapies to treat a range of rare and more common retinal diseases that result in blindness. The ... READ MORE
Ten researchers receive Oxford BRC training bursaries
Ten Oxford BRC-affiliated research staff have been awarded bursaries to support their training and career development. The BRC research training bursary scheme – worth up to £3,500 - provides funding for short courses or modules which will provide training and expertise in research skills or ... READ MORE
Multi-cancer blood test shows real promise in NHS trial
An NHS trial of a new blood test for more than 50 types of cancer correctly revealed two out of every three cancers in more than 5,000 people who had visited their GP with suspected symptoms. The test also correctly identified the original site of cancer in 85 percent of those cases. The ... READ MORE
Research profile: the importance of doing research alongside clinical work
Francesca Tabacchi, a specialist oncology dietitian at Oxford University Hospitals, is currently being funded by the NIHR Oxford Biomedical Research Centre to do a PhD on malnutrition and nutritional support in cancer patients undergoing chemotherapy. “I was very excited to start my research ... READ MORE
My journey towards being a citizen scientist – Maria Buckley, Step Change project
The NIHR Oxford Biomedical Research Centre is part of STEP CHANGE, a three-year European Commission project to support five citizen science projects. The study being led by the BRC is looking at the role of steroid hormones in the treatment of non-alcoholic fatty liver disease (NAFLD), obesity and ... READ MORE
New imaging centre performs first stroke thrombectomy
A new imaging centre at the John Radcliffe Hospital carried out its first stroke thrombectomy. The Acute Multidisciplinary and Interventional Centre (AMIIC) carried out the procedure on 17 May as part of its partnership with Oxford University Hospitals (OUH) NHS Foundation Trust. A ... READ MORE
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