Researchers in Oxford using an ‘atlas’ of immune cells in the human colon have found evidence of the role of CD8 T cells in inflammatory bowel disease (IBD). The findings could lead to a better understanding of how cells behave and interact in people with IBD, and could pave the way for more targeted treatments … Read more
News for Gastroenterology and Mucosal Immunity
BRC funds three further COVID-19 studies
Three more studies are being funded by the NIHR Oxford Biomedical Research Centre (BRC) to look at the way the body interacts with COVID19; these include assessing the safety of a new vaccine; the role that antibodies might play in plasma therapy; and blood biomarkers that determine adverse reactions in those that have been infected. … Read more
Common antibody test can be adapted for COVID-19, study finds
Research led from Oxford has found that an immunological assay commonly used to measure antibodies, antigens and proteins in biological samples can be specifically adapted to detect and quantifying COVID-19 antibodies. The investigations by the National COVID Testing Scientific Advisory Panel were co-ordinated by Prof Derrick Crook at the University of Oxford. The trial involved researchers at … Read more
Oxford researchers to play key role in fight-back against COVID-19
Researchers supported by the NIHR Oxford Biomedical Research Centre will play a crucial role in tackling the current COVID-19 pandemic, ranging from the development of a new vaccine to developing the most effective drug treatments for people who have contracted the virus. A team from the Oxford Vaccine Group and the University of Oxford’s Jenner … Read more
Oxford professors appointed NIHR Senior Investigators
Four leading healthcare academics in Oxford have received a prestigious national award. The University of Oxford professors were named National Institute of Health Research (NIHR) Senior Investigators in recognition of being “among the most prominent and prestigious researchers funded by the NIHR and the most outstanding leaders of patient and people-based research within the NIHR research community and … Read more
Researchers identify link in the treatment of inflammatory bowel disease
A new study involving Oxford researchers has revealed how the anti-inflammatory cytokine IL-10 and lipid mediator prostaglandin E2 (PGE2) work together to prevent inflammatory tissue damage and maintain a healthy gut balance. Inflammatory bowel diseases (IBD), which include Crohn’s disease (CD) and ulcerative colitis (UC), are chronic painful inflammatory conditions of the gastrointestinal tract, which … Read more
Researchers find new cells that repair tissue
Researchers at Oxford University have discovered that a newly discovered group of cells can help repair tissues in the body. The researchers, who are supported by the NIHR Oxford Biomedical Research Centre, say these cells, which are abundant in our bodies, could be harnessed to help heal tissues and treat diseases such as infections of … Read more
Oxford patients take part in study to understand role of stress in managing Crohn’s disease
Around 60 Oxford University Hospitals (OUH) NHS Foundation Trust patients are to take part in a study to look at how wearable and mobile devices can help us to understand the relationship between stress and the symptoms of Crohn’s disease, and help to improve management of the condition. The research is part of a larger … Read more
BRC researchers elected Fellows of Academy of Medical Sciences
Three Oxford BRC-supported researchers are among eight University of Oxford scientists elected to join the prestigious Fellowship of the Academy of Medical Sciences (AMS) this year. The BRC researchers among the new Fellows are: Professor Helen McShane, Professor of Vaccinology in the Nuffield Department of Medicine, Deputy Director of the Medical Sciences Division and Director … Read more
Research identifies how the gut loses protective barrier function in IBD
A University of Oxford research team has used single-cell technology to identify new players in the gut epithelial barrier, the single-cell layer that forms the lining of the small and large intestine. The team from the MRC Human Immunology Unit (HIU), whose paper was published in the journal Nature, were supported by the NIHR Oxford … Read more