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Gastroenterology and Mucosal Immunity

You are here: Home > News listings for Gastroenterology and Mucosal Immunity

News for Gastroenterology and Mucosal Immunity

Paediatric IBD BioResource opens to support vital research

28 April 2022 · Listed under Gastroenterology and Mucosal Immunity

A new National Institute for Health and Care Research (NIHR) BioResource aimed at investigating inflammatory bowel disease (IBD) in children has opened, with the NIHR Oxford BRC playing a key role. The new Paediatric Inflammatory Bowel Disease (PIBD) BioResource will drive research into Crohn’s disease and ulcerative colitis in children. It aims to recruit paediatric … Read more

Oxford BRC researchers named NIHR Senior Investigators

3 March 2022 · Listed under Clinical Informatics and Big Data, Gastroenterology and Mucosal Immunity, Musculoskeletal, Respiratory, Surgical Innovation and Evaluation

Seven Oxford academics, six of them supported by the NIHR Oxford Biomedical Research Centre (BRC), have been named National Institute of Health Research (NIHR) Senior Investigators in recognition of their outstanding leadership in research. The NIHR describes its Senior Investigators as among the “most prominent and prestigious researchers” and “most outstanding leaders of patient and people-based research within … Read more

Genetic study highlights links between IBS and mental health disorders

10 November 2021 · Listed under Clinical Informatics and Big Data, Gastroenterology and Mucosal Immunity, Genomic Medicine

Research funded and supported by the NIHR has revealed that symptoms of irritable bowel syndrome (IBS) may be caused by the same biological processes as mental health conditions such as anxiety. IBS is a common condition worldwide, affecting around 1 in 10 people. The condition causes a wide range of symptoms including abdominal pain, bloating … Read more

New therapeutic targets identified to treat inflammatory bowel disease

25 October 2021 · Listed under Gastroenterology and Mucosal Immunity

A new study by University of Oxford researchers has identified potential new therapeutic targets for the treatment of inflammatory bowel disease (IBD), giving hope to millions of patients with ulcerative colitis or Crohn’s disease. The research team from the University’s Kennedy Institute of Rheumatology and Translational Gastroenterology Unit (TGU) were supported by the NIHR Oxford … Read more

New atlas reveals pre-birth development of blood cells in bone marrow

29 September 2021 · Listed under Gastroenterology and Mucosal Immunity, Haematology and Stem Cells, Oxford Blood Group

A new study has provided the most detailed analysis so far of the prenatal development of blood and immune cells in the bone marrow. The study, published in Nature, is part of the Human Cell Atlas (HCA) initiative to provide comprehensive reference maps of every cell type in the human body. The research team include … Read more

MAIT Cell activation may play role in COVID-19 deaths, study finds

17 September 2021 · Listed under COVID-19, Gastroenterology and Mucosal Immunity

Oxford researchers have found a correlation between deaths from COVID-19 infections and a poorly coordinated systemic immune response, as well as increased activity by Mucosal Associated Invariant T cells, or ‘MAIT cells’. A study involving Oxford BRC-supported researchers published in PLOS Pathogens suggests there is a link between inflammatory responses in the body and increased mortality. In … Read more

New study launched to understand vaccine escape

26 August 2021 · Listed under Antimicrobial Resistance and Modernising Microbiology, COVID-19, Gastroenterology and Mucosal Immunity, Vaccines for Emerging and Endemic Diseases

Oxford researchers will be involved in a major new study seeking to understand why some people become infected after vaccination or prior infection while others do not Oxford BRC-supported investigators already involved in the Protective Immunity from T-Cells in Healthcare workers (PITCH) study will be part of a consortium of academic partners involved in the … Read more

Liver problems common among COVID-19 patients, study finds

23 July 2021 · Listed under Clinical Informatics and Big Data, COVID-19, Gastroenterology and Mucosal Immunity

A study by Oxford University researchers has found that liver problems are common among patients with COVID-19. Patient data revealed that baseline hypoalbuminemia (an possible indication that the liver is producing low levels of albumin) and rising alkaline phosphatase (ALP), which can be a sign of liver damage, could be prognostic markers for death. However, the … Read more

Latest data on immune response to COVID-19 reinforces need for vaccination

17 June 2021 · Listed under Antimicrobial Resistance and Modernising Microbiology, COVID-19, Gastroenterology and Mucosal Immunity, Vaccines for Emerging and Endemic Diseases

A new study led by University of Oxford has found that previous infection, whether it was symptomatic or asymptomatic, does not necessarily protect you long term from COVID-19, particularly against new variants of concern. The PITCH Study (Protective Immunity from T cells to COVID-19 in Health workers) examined how the immune system responds to COVID-19 … Read more

AI endoscopy enables 3D surface measurements of pre-cancerous condition in oesophagus

9 June 2021 · Listed under Gastroenterology and Mucosal Immunity, Imaging, Multi-Modal Cancer Therapies

Clinicians and engineers in Oxford have begun using artificial intelligence alongside endoscopy to get more accurate readings of the pre-cancerous condition Barrett’s oesophagus and so determine patients most at risk of developing cancer. In a research paper published in the journal Gastroenterology, the researchers said the new AI-driven 3D reconstruction of Barrett’s oesophagus achieved 97.2 … Read more

Oxford BRC researchers named among new Academy of Medical Sciences fellows

12 May 2021 · Listed under Clinical Informatics and Big Data, COVID-19, Gastroenterology and Mucosal Immunity, Neurological Conditions, Vaccines for Emerging and Endemic Diseases

A number of leading researchers supported by the NIHR Oxford Biomedical Research Centre are among 50 prominent biomedical and health scientists elected to the Academy of Medical Sciences’ respected and influential Fellowship. The new Fellows include Oxford BRC experts who have spearheaded the COVID-19 response, such as Professor Sarah Gilbert, who led the team developing … Read more

Oxford researchers release cheap, quick COVID-19 antibody test

29 March 2021 · Listed under COVID-19, Gastroenterology and Mucosal Immunity

An international research team led by Oxford University scientists has developed a portable test for antibodies that fight the novel coronavirus that causes COVID-19. The test, which spots the presence of virus-fighting antibodies rather than a coronavirus infection, can be adapted to work on blood from a finger prick, making it quick and easy to … Read more

New study finds strong immune response following COVID-19 vaccination

26 March 2021 · Listed under Antimicrobial Resistance and Modernising Microbiology, COVID-19, Gastroenterology and Mucosal Immunity, Vaccines for Emerging and Endemic Diseases

A new study has found that 99% of people generate a robust immune response against COVID-19 after just one dose of the Pfizer vaccine, and that after two doses levels of protection were even stronger. The PITCH (Protective Immunity from T cells to COVID-19 in Health workers) study, led by Oxford and Sheffield Universities with … Read more

Oxford academics named NIHR Senior Investigators

3 March 2021 · Listed under Gastroenterology and Mucosal Immunity, Musculoskeletal, Other News, Surgical Innovation and Evaluation, Technology and Digital Health, Vaccines for Emerging and Endemic Diseases

Four academics supported by the NIHR Oxford Biomedical Research Centre have been awarded a prestigious national award. The University of Oxford  professors have been named National Institute of Health Research (NIHR) Senior Investigators in recognition of being “among the most prominent and prestigious researchers funded by the NIHR and the most outstanding leaders of patient and people-based research within the NIHR research … Read more

Oxford collaborates with Janssen to map the cellular landscape of immune mediated disorders

16 February 2021 · Listed under Gastroenterology and Mucosal Immunity

The University of Oxford has entered into a strategic collaboration with Janssen Biotech to develop a cellular map of genes and proteins implicated across a range of immune-mediated inflammatory disorders and to characterise pharmacologically relevant therapeutic targets. Lead Oxford investigator for the project, Professor Holm Uhlig, said: “This exciting endeavour brings together a world-leading group … Read more

Paper urges use of genomics in care of monogenic IBD

5 January 2021 · Listed under Gastroenterology and Mucosal Immunity

Gastroenterology experts have had a position paper published that calls for genomic technologies to be considered an integral part of patient care to investigate patients at risk for monogenic forms of inflammatory bowel disease (IBD). The authors include a number of NIHR Oxford BRC-supported researchers. The paper, published in the Journal of Paediatric Gastroenterology and … Read more

IBD treatments do not increase susceptibility to COVID-19, study finds

23 December 2020 · Listed under COVID-19, Gastroenterology and Mucosal Immunity

Research by Oxford scientists has shown that rates of COVID-19 infection are not increased in patients with inflammatory bowel disease (IBD) who are being treated with the drugs infliximab or vedolizumab. The study data suggest there is no reason for treatment with these drugs to be stopped. The paper, published on the pre-print server medRxiv, … Read more

Using AI to improve the quality of endoscopy videos

25 November 2020 · Listed under Gastroenterology and Mucosal Immunity, Multi-Modal Cancer Therapies, Technology and Digital Health

A multidisciplinary team of researchers has developed a deep-learning framework for improving endoscopy to aid the detection of cancer and other gastrointestinal diseases. Cancers detected at an earlier stage have a much higher chance of being treated successfully. The main method for diagnosing cancers of the gastrointestinal tract is endoscopy, when a long flexible tube … Read more

Patients with cirrhosis at increased risk of death from COVID-19, study finds

6 October 2020 · Listed under COVID-19, Gastroenterology and Mucosal Immunity

An international study led by researchers at Oxford University Hospitals NHS Foundation Trust has shown that patients with cirrhosis are at increased risk of dying as a result of COVID-19. The study, published in the Journal of Hepatology, found that mortality from COVID-19 was particularly high among patients with more advanced cirrhosis (called Childs-Pugh B … Read more

Persistent immune memory of COVID-19 found in recovered patient T cells

10 September 2020 · Listed under COVID-19, Gastroenterology and Mucosal Immunity

Oxford University researchers have found that infection with COVID-19 produces a robust T cell response, including inducing T cell ‘memory’ to potentially fight future infections. The results, published in Nature Immunology, are a joint effort from the Oxford COVID-19 immunology group, led by the Medical Research Council Human Immunology Unit at the MRC Weatherall Institute of Molecular Medicine … Read more

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Gastroenterology and Mucosal Immunity Theme

  • Introduction
  • Sub-theme 1: Molecular pathway analysis
  • Sub-theme 2: Biomarker and drug target development
  • Sub-theme 3: Experimental medicine trials
  • Projects awarded with response mode funds
  • Principal investigators
  • Constituent research institutes
  • Contacts
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