An international team of researchers has developed an experimental blood test that could help to identify biological changes linked to Parkinson’s disease, opening a potential path towards earlier and less invasive diagnosis of the disease. The researchers included scientists from the ... READ MORE
News Archive
Study of Bundibugyo Ebola candidate vaccine launched in Uganda
A Phase I clinical study evaluating the safety of and immune response to a candidate vaccine against Bundibugyo virus disease (BVD), a severe form of the Ebola virus that has claimed over 4,000 lives in the Democratic Republic of Congo since May, has begun in neighbouring Uganda. The study, ... READ MORE
Brain immune cells protect neurons in Parkinson’s disease by ‘nibbling’ harmful material
New research has revealed how a specialised population of the brain’s immune cells can remove harmful protein clumps from nerve cells (neurons), pointing to potential new treatments for Parkinson’s disease. Researchers at the University of Oxford, supported by the National Institute for Health ... READ MORE
BLOG: The answer was already there: how long-read sequencing is ending the rare disease diagnostic odyssey
When rare disease cases go unsolved, the answer isn't always missing - sometimes it's just hard to find. In a new BRC Oxford-supported study, Dr Prasun Dutta, Senior Bioinformatician at the University of Oxford’s Centre for Human Genetics, and colleagues used long-read genetic sequencing to diagnose ... READ MORE
Positive results reported in trial of gene therapy to treat inherited cause of blindness
A new gene therapy being developed to treat the most common cause of blindness in young people has shown encouraging results in a major clinical trial. X-linked retinitis pigmentosa (XLRP), which is currently untreatable, is an inherited condition caused by mutations to the RPGR gene. These ... READ MORE
Social care data could help identify changing health and care needs earlier
New research shows that routinely collected social care records can help predict which people will need hospital admission or who may die in the next one to three years. The findings suggest there is great potential in linking health and social care information to support more proactive, ... READ MORE
How body fat is stored across organs may reveal hidden health risks, study suggests
University of Oxford researchers have found that how fat accumulates in the body is just as important for identifying different health risks as a person’s overall weight. They say their findings suggest that looking at how fat is distributed across the whole body, including in and around multiple ... READ MORE
Shingles vaccine linked to lower risk of cardiovascular events, study finds
New evidence shows that the current shingles vaccine reduces the risk of major cardiovascular events – including coronary heart disease, heart failure and stroke – compared to the previous shingles vaccine. A study of more than 70,000 people by researchers at the University of Oxford, supported ... READ MORE
Immune cells offer clues to early stages of lung fibrosis
Oxford researchers have identified a striking immune cell signature that may help to explain what happens in the early stages of idiopathic pulmonary fibrosis (IPF), a serious condition that causes scarring of the lungs and makes breathing difficult. IPF is usually diagnosed after significant ... READ MORE
Oxford researchers win prestigious national leadership prizes
A leading Oxford orthopaedic trauma surgeon and a researcher specialising in the use of artificial intelligence (AI) in healthcare have been recognised with prestigious national research leadership prizes in recognition of their outstanding contribution to health and care research. Professor of ... READ MORE
Bringing vital clinical understanding to translational research
Associate Professor Sarah Vollam has worked on NIHR Oxford Biomedical Research Centre (BRC) projects since 2009, progressing from research nurse to BRC sub-theme lead in the process and developing her expertise in the use of wearables to enhance patient recovery after critical care. In late 2025, ... READ MORE
Researchers uncover how Parkinson’s disease protein damages brain cells
A new study has revealed a key mechanism by which a protein associated with Parkinson's disease damages neurons (brain cells) by blocking a vital cellular gateway. The findings help to explain how the disease begins and highlights a potential new target for treatment. Parkinson's disease, which ... READ MORE
First patient dosed in oesophageal cancer vaccine trial
An Oxford-led clinical trial has given the first patient an experimental cancer vaccine designed to help the immune system recognise and attack oesophageal (gullet) cancer. The VISTA trial, which is supported by the NIHR Biomedical Research Centre: Oxford, is testing a vaccine called ITOP1, ... READ MORE
First patient receives trial vaccine to prevent Lynch syndrome-associated cancers
The first participant has received an investigational vaccine that researchers hope will help to prevent cancer in people with Lynch syndrome (LS). The INTERCEPT-Lynch trial, which is supported by the NIHR Biomedical Research Centre: Oxford, forms part of a scientific collaboration between the ... READ MORE
Recruitment under way in ground-breaking hepatitis C study
The first stage of recruitment has begun in a University of Oxford study that will see participants infected with the hepatitis C virus – and treated – an important first step on the road to possible future testing of vaccine candidates against the disease. If untreated, hepatitis C can cause ... READ MORE
Oxford-led newborn screening pilot expanded to include all babies in England
Every newborn baby in England will be screened for spinal muscular atrophy (SMA), following the expansion of a pioneering University of Oxford-led pilot that introduced the country’s first routine test for the condition. The national evaluation programme, announced by the government ... READ MORE
University of Oxford launches trial of new Ebola vaccine
Vaccine researchers at the University of Oxford have launched the world’s first clinical trial of a vaccine against the Bundibugyo species of Ebola virus, in response to the ongoing outbreak in the Democratic Republic of the Congo and neighbouring Uganda. Conducted in Oxford, the Phase I ... READ MORE
World-first perfused pancreas transplant marks major milestone
University of Oxford researchers have carried out the world’s first successful transplantation of a perfused human pancreas, a major advance in efforts to improve organ preservation for transplantation. The preclinical work was supported by the NIHR Biomedical Research Centre: Oxford. The ... READ MORE
OUH healthcare professionals embark on research career
Six Oxford University Hospitals healthcare professionals have completed the first stage of their research journey by presenting the research projects they have undertaken on the NIHR BRC: Oxford internship programme. Every year, the NIHR Biomedical Research Centre: Oxford (BRC) makes funds ... READ MORE
AI tool reveals hidden organ damage caused by high blood pressure
Researchers at the University of Oxford have developed an artificial intelligence (AI) tool that may help doctors better understand how high blood pressure damages different organs in different people - potentially paving the way for more personalised treatment in future. The ... READ MORE
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