Oxford researchers have been awarded up to £600,000 from Cancer Research UK (CRUK) to create the world’s first vaccine to prevent ovarian cancer. Scientists at the University of Oxford’s MRC Weatherall Institute of Molecular Medicine (MRC-WIMM), led by Professor Ahmed Ahmed, are designing ... READ MORE
News for Life-saving Vaccines
New campaign launched to encourage vaccine uptake
Parents are being urged to get their children vaccinated as part of a campaign to boost uptake in the UK amid rising cases of whooping cough and measles. Researchers at the Oxford Vaccine Group, which is part of the University of Oxford and supported by the NIHR Oxford Biomedical Research Centre ... READ MORE
Dr Clement Twumasi – underpinning our research with statistical expertise
Dr Clement Twumasi is an Oxford BRC-supported medical statistician whose role involves providing a range of statistical support for clinical trials and other vaccine-related studies, as well as assisting with funding applications. Based at the University of Oxford’s Nuffield Department of ... READ MORE
Funding announced for hepatitis C controlled human infection model trial
A proposed groundbreaking study that will see participants infected with hepatitis C - and treated - has secured more than £1million in funding. The study will help pave the way for future testing of hepatitis C vaccine candidates. The £1,098,103 funding from the research and grant-making ... READ MORE
New study to improve vaccines and therapeutics development
A first-of-its-kind study led by the University of Oxford has successfully investigated human immunity against COVID-19 in people who already have antibodies against it. The results suggest that previous infection, together with vaccination, offers strong protection against the original ... READ MORE
Breakthrough aerosol human infection model gives hope for future TB vaccine development
University of Oxford researchers have for the first time established a controlled human infection model for tuberculosis (TB) that infects people via the lungs – the way TB enters the body. The clinical trial, which used the BCG vaccine delivered via aerosol into participants’ lungs, is a first ... READ MORE
Trial studies inhalation of TB vaccine
A new clinical trial has been launched in Oxford to determine the effectiveness of delivering tuberculosis (TB) vaccines through inhalation. The study is being conducted by researchers at the University of Oxford’s Jenner Institute, who are giving BCG, the current licensed vaccine against ... READ MORE
Vaccine trial for deadly Nipah virus launched
The first participants have received doses of a new vaccine against Nipah virus in a clinical trial by University of Oxford researchers. Nipah virus is a devastating disease mostly found in South-East Asia that can be fatal in up to 75 percent of cases. This first-in-human trial of the vaccine ... READ MORE
Oxford Vaccine Group receives £7.8m in research funding to fight pandemic threats
The Oxford Vaccine Group (OVG), which led the rapid clinical development of the Oxford vaccine in COVID-19 in the pandemic, has been awarded £7.8 million by UK Aid for research into the prevention of five dangerous diseases with epidemic or pandemic potential. The awards will fund research into ... READ MORE
Small cash incentives improve vaccine uptake in rural areas of Ghana
Researchers from Oxford and Ghana have shown that small cash incentives increased COVID-19 vaccine uptake in rural Ghana. The findings, published in Nature Medicine, could offer a new strategy for enhancing health interventions in Africa. The recent COVID-19 pandemic highlighted the ... READ MORE
WHO recommends Oxford malaria vaccine for use
The R21/Matrix-MTM malaria vaccine developed by the University of Oxford and the Serum Institute of India has been recommended for use by the World Health Organisation (WHO), paving the way for its global roll-out. The WHO made the announcement after the vaccine, developed with support from the ... READ MORE
Research profile: “You see the impact of your research in clinical care. It’s part of the same circle”
Lizzie Stafford, a Clinical Research Nurse Manager in the Nuffield Department of Medicine, has been involved in number of Oxford BRC-supported research studies. The BRC is funding the second year of her NIHR postgraduate clinical research programme. “I’ve been involved in some ground-breaking ... READ MORE
Real-world vaccine response in patients with impaired immune systems revealed
Updated data from the ongoing OCTAVE study reveal, for the first time, the real-world vaccine responses and infection outcomes in clinically at-risk patients with a range of immunocompromised or immunosuppressed conditions. Preliminary data from the landmark OCTAVE study in August 2021 showed ... READ MORE
Landmark antibody study to test immune responses against COVID-19
Thousands of immunosuppressed people, including patients at Oxford University Hospitals (OUH), have the chance to take part in a landmark new study investigating which people are still at the greatest risk of COVID-19 infection after vaccination. Researchers hope the STRAVINSKY study’s findings ... READ MORE
Malaria booster vaccine continues to meet WHO efficacy goal
Researchers from the University of Oxford and their partners have reported new findings from their Phase 2b trial which tested the effectiveness of a booster dose of their candidate malaria vaccine. The vaccine, R21/Matrix-M, had previously demonstrated high-level efficacy of 77 ... READ MORE
Human trials of aerosol-based TB vaccine begin
University of Oxford researchers have begun recruiting for a phase I clinical trial of a tuberculosis vaccine in human volunteers to develop a new way to test the efficacy of future TB vaccines. The study is led by the Director of the NIHR Oxford Biomedical Research Centre (BRC), Helen McShane, ... READ MORE
Oxford BRC’s ability to deliver rapid COVID-19 research response highlighted
Oxford Biomedical Research Centre (BRC) researchers have highlighted how the BRC’s infrastructure gave it the agility and capacity to respond rapidly with research projects to tackle COVID-19. In a commentary published in the open access BMC Health Research Policy and Systems journal, the ... READ MORE
COVID-19 infection more likely than vaccines to cause rare cardiovascular complications
Researchers have reported the results of the largest ever study to compare the risks of cardiovascular events - such as myocarditis, pericarditis, and cardiac arrhythmia - between different vaccines and COVID-19 infection, and the first to investigate the association between cardiac events and the ... READ MORE
New study launched to understand vaccine escape
Oxford researchers will be involved in a major new study seeking to understand why some people become infected after vaccination or prior infection while others do not Oxford BRC-supported investigators already involved in the Protective Immunity from T-Cells in Healthcare workers (PITCH) study ... READ MORE
Delayed second dose and third doses of the Oxford vaccine lead to heightened immune response to COVID-19
A longer delay of up to 45 weeks between the first and second dose of the Oxford-AstraZeneca vaccine leads to enhanced immune response after the second dose, the latest research by the Oxford Vaccine Group has found. They also found that a third dose given more than six months after the second ... READ MORE
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