Videos on the Oxford BRC YouTube Channel

Dr Mark Sheehan of the University of Oxford’s Ethox Centre wraps up the key themes of the first of a series of workshops and seminars on personalised medicine, held at St Anne's College, Oxford, on 21 March 2019, and jointly organised by the Centre for Personalised Medicine and the NIHR Oxford Biomedical Research Centre's Partnerships for Health, Wealth and Innovation Theme. The event aimed to identify major social challenges around personalised medicine – developing new knowledge, tools and solutions.

Prof Joshua Hordern, Professor of Christian Ethics at the University of Oxford, talks about the theological dimensions of personalised medicine. He was speaking at the first of a series of workshops and seminars on personalised medicine at St Anne's College, Oxford, on 21 March 2019, jointly organised by the Centre for Personalised Medicine and the NIHR Oxford Biomedical Research Centre's Partnerships for Health, Wealth and Innovation Theme. The event aimed to identify major social challenges around personalised medicine – developing new knowledge, tools and solutions.

Prof Mike Parker, of the University of Oxford’s Ethox Centre, talks about the emerging ethical challenges of personalised medicine. He was speaking at the first of a series of workshops and seminars on personalised medicine at St Anne's College, Oxford, on 21 March 2019, jointly organised by the Centre for Personalised Medicine and the NIHR Oxford Biomedical Research Centre's Partnerships for Health, Wealth and Innovation Theme. The event aimed to identify major social challenges around personalised medicine – developing new knowledge, tools and solutions.

Prof Paresh Vyas, Professor of Haematology at the University of Oxford, talks about the personalised medicine approach in treating blood cancers. He was speaking at the first of a series of workshops and seminars on personalised medicine at St Anne's College, Oxford, on 21 March 2019, jointly organised by the Centre for Personalised Medicine and the NIHR Oxford Biomedical Research Centre's Partnerships for Health, Wealth and Innovation Theme. The event aimed to identify major social challenges around personalised medicine – developing new knowledge, tools and solutions. Prof Vyas is the Theme Lead for both Haematology and Molecular Diagnostics at the Oxford Biomedical Research Centre.

Dr Tom Fowler, Deputy Chief Scientist and Director of Public Health at Genomics England, talks about the 100,000 Genomes Project and the UK’s new Genomic Medicine Service, and their importance in the context of personalised medicine. He was speaking at the first of a series of workshops and seminars on personalised medicine at St Anne's College, Oxford, on 21 March 2019, jointly organised by the Centre for Personalised Medicine and the NIHR Oxford Biomedical Research Centre's Partnerships for Health, Wealth and Innovation Theme. The event aimed to identify major social challenges around personalised medicine – developing new knowledge, tools and solutions.

Prof Ian Pavord, Professor of Respiratory Medicine at the University of oxford’s Nuffield Department of Medicine, describes recent efforts to transform classifications and treatment of chronic airways conditions, including asthma and COPD. He was speaking at the first of a series of workshops and seminars on personalised medicine at St Anne's College, Oxford, on 21 March 2019, jointly organised by the Centre for Personalised Medicine and the NIHR Oxford Biomedical Research Centre's Partnerships for Health, Wealth and Innovation Theme. The event aimed to identify major social challenges around personalised medicine – developing new knowledge, tools and solutions. Prof Pavord is the Respiratory Theme Lead for the Oxford Biomedical Research Centre.

With one in three people in the UK affected by insomnia, improving our sleep quality is fast becoming a key public health priority. In this public talk at the John Radcliffe Hospital on 4 July 2019, Dr Simon Kyle explains how sleep disruption affects mental health and how digital CBT can be an effective treatment for chronic insomnia. Dr Simon Kyle is Associate Professor at the Nuffield Department of Clinical Neurosciences and Programme Director for the Oxford Online Programme in Sleep Medicine.

Dr Nick Fahy of the University of Oxford's Nuffield Department of Primary Care Health Sciences considers how health policy and systems can support innovation in personalised medicine. He was speaking at the first of a series of workshops and seminars on personalised medicine at St Anne's College, Oxford, on 21 March 2019, jointly organised by the Centre for Personalised Medicine and the NIHR Oxford Biomedical Research Centre's Partnerships for Health, Wealth and Innovation Theme. The event aimed to identify major social challenges around personalised medicine – developing new knowledge, tools and solutions.

Prof Barbara Prainsack of the University of Vienna delivers the keynote lecture at the first of a series of workshops and seminars on personalised medicine at St Anne's College, Oxford, on 21 March 2019, drawing on her recent book about personalised medicine. The event was jointly organised by the Centre for Personalised Medicine and the NIHR Oxford Biomedical Research Centre's Partnerships for Health, Wealth and Innovation Theme. The event aimed to identify major social challenges around personalised medicine – developing new knowledge, tools and solutions.

Dr Simon Leedham, Director of the University of Oxford's Centre for Personalised Medicine, opens the first of a series of workshops and seminars on personalised medicine at St Anne's College, Oxford, on 21 March 2019, jointly organised by the Centre for Personalised Medicine and the NIHR Oxford Biomedical Research Centre's Partnerships for Health, Wealth and Innovation Theme. The event aimed to identify major social challenges around personalised medicine – developing new knowledge, tools and solutions.

This panel discussion, Artificial intelligence: how to ensure it benefits patients, was held at the NIHR Oxford BRC Open Day in May 2019. Chaired by Prof Lionel Tarassenko, the Oxford BRC’s Technology & Digital Health Theme Lead, the panel featured: · Prof Chris Holmes, Professor of Biostatistics at the Department of Statistics and Nuffield Department of Medicine · Dr Fred Kemp, Deputy Head of Licensing & Ventures, Life Sciences at Oxford University Innovation · Dr Angeliki Kerasidou, Researcher in Global Health Ethics at the Ethox Centre · Dr Nick Scott-Ram, Director at the Oxford Martin School and VP Strategic and Commercial Development at Sensyne Health

Our understanding of asthma and other airways diseases has developed significantly in recent years, but this has not necessarily translated into improved treatments for many people living with these conditions. Speaking at the Oxford BRC’s Open Day in May 2019, Prof Ian Pavord, the BRC’s Theme Lead for Respiratory Medicine, explained that the discovery of biomarkers such as eosinophilic airway inflammation should lead to a more stratified and targeted approach to treating patients. Prof Pavord was joined by Beth Noray, an asthma patient who has taken part in clinical trials, who gave her perspective on what participating in research has meant to her and how she views her condition.

In 2017, the Intensive Care unit at Oxford’s John Radcliffe Hospital was hit by an outbreak of the potentially deadly fungal pathogen Candida auris. Through a combination of good infection prevention and control, whole genome sequencing and electronic patient data, Oxford University Hospitals (OUH), supported by NIHR Oxford BRC researchers, became the first NHS trust to halt such an outbreak with a clear understanding of the cause. Speaking at the Oxford BRC’s Open Day in May 2019, the Director of Infection Prevention and Control at OUH, Dr Katie Jeffery, and Dr David Eyre, of the Nuffield Department of Medicine and Big Data Institute, explained how the ‘superfungus’ was stopped in its tracks.

The Molecular Diagnostics Theme is focused on improving medicine by better classification of disease, allowing more accurate prediction of patients’ prognosis and better prediction of how they will respond to different treatments. This will help to offer the most suitable treatments to patients with cancer and other diseases. NIHR Oxford BRC Molecular Diagnostics Theme Lead, Prof Paresh Vyas, explain

For many diseases a large proportion of patients will be a low risk of developing the serious complication of their disease becoming uncontrolled over time. It is therefore important to be able to identify those few patients who are at risk of a poor outcome. This will save the lower risk patients unnecessary investigation, treatment or surveillance, and focus our resources on those at highest risk. As an example, we will attempt to use genetic analysis of precancerous polyps and stem cells to separate patients with bowel inflammation (ulcerative colitis) into those at high and low risk of severe inflammation or bowel cancer. https://www.youtube.com/watch?v=eBJMFotN9tM&t=18s

NIHR Oxford Biomedical Research Centre, Molecular Diagnostics Theme Advances in technology mean that we now have an unprecedented ability to identify the molecular alterations that drive the growth and spread of cancers. While many of these alterations are likely to be associated with differences in prognosis or probability of treatment benefit, current analytical methods are inadequate to confirm this in cases where the alteration is uncommon, or in cases where multiple alterations are present. In the Precision Biomarkers sub-theme, we will develop new statistical methods to address this challenge. Our aim is to realise the potential of new technologies to refine care for patients with cancer, and in so, doing reduce both under- and over- treatment. In addition to improving cancer care, the methods we seek to develop should be applicable to other disease types, and thus help to achieve the ambition of Precision Medicine more broadly.

Dr Alastair Webb: Stroke – don’t let the pressure get to you! High blood pressure is a contributing factor in around half of all strokes. On top of the 9.5 million people diagnosed with high blood pressure in the UK, an estimated 5.5 million are undiagnosed and untreated. In this public talk at the John Radcliffe Hospital on 18 October 2016, Dr Alastair Webb explains how high blood pressure affects the brain and how diagnosing high blood pressure can improve the prevention of stroke and other vascular diseases. Dr Webb is a Wellcome Trust Clinical Research Development Fellow, at the Centre for the Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, University of Oxford; and an Honorary Neurology Consultant with Oxford University Hospitals NHS Foundation Trust. To find out more about our research into stroke and vascular conditions: https://oxfordbrc.nihr.ac.uk/research-themes-overview/stroke-and-vascular-dementia/ and into neurological conditions: https://oxfordbrc.nihr.ac.uk/research-themes-overview/neurological-conditions/