A number of leading researchers supported by the NIHR Oxford Biomedical Research Centre are among 50 prominent biomedical and health scientists elected to the Academy of Medical Sciences’ respected and influential Fellowship. The new Fellows include Oxford BRC experts who have spearheaded the COVID-19 response, such as Professor Sarah Gilbert, who led the team developing … Read more
Data reveals COVID-19 risk factors for people with type 1 diabetes
The largest study of people with type 1 diabetes admitted to hospital with COVID-19 has found that those with higher body mass index (BMI), poorer kidney function and the presence of microvascular complications were at greater risk of death and/or admission to intensive care. However, the study, supported by the NIHR Oxford Biomedical Research Centre, … Read more
Study reveals three most important aspects of care for hip fractures
Older patients with hip fractures recover better if they receive treatment under the supervision of both a surgeon and a specialist in elderly care; are checked to avoid future falls; and are assessed for memory problems. These are the findings of the World Hip Trauma Evaluation (WHiTE) study, published in the Bone and Joint Journal. … Read more
Foods linked to greater risk of cardiovascular disease and death in middle-age identified
Two common dietary patterns identified in British adults may be associated with an increased risk of cardiovascular disease and death in middle-age, according to a study by Oxford University researchers. The research, which was supported by the NIHR Oxford Biomedical Research Centre, was published in the open access journal BMC Medicine, found that high intakes … Read more
More people could benefit from blood pressure-lowering medication, study finds
Blood pressure-lowering medication can prevent serious cardiovascular conditions such as strokes, heart failure and heart attacks, even in adults with normal blood pressure, according to a new research by University of Oxford researchers In a paper published in the Lancet, the researchers found the beneficial effects of treatment were similar, regardless of the starting blood … Read more
Study highlights role of BMI in increased COVID-19 risks
A study by University of Oxford researchers has found that the risk of admission to hospital, admission to ICU or death from COVID-19 increases progressively above a ‘normal’ BMI of 23, even without other comorbidities. The research team, who are supported by the NIHR Oxford Biomedical Research Centre (BRC), found that BMI is a greater … Read more
Study challenges idea of clinically significant mid-pregnancy drop in blood pressure
An international study involving NIHR Oxford BRC researchers has shown where normal blood pressure in pregnancy should be across the world and when clinicians should react because it is abnormal. The study’s findings, published in PLOS Medicine, provide international, gestational age-specific centiles and limits of acceptable change to facilitate earlier recognition of deteriorating health in … Read more
Azithromycin not effective against COVID-19, trial confirms
A clinical trial by University of Oxford researchers has confirmed that the antibiotic azithromycin has no clinical benefit in people with moderate COVID-19. The ATOMIC2 trial, which was supported by the NIHR Oxford Biomedical Research Centre (BRC), was established to investigate if a common antibiotic called azithromycin could prevent patients with mild-moderate COVID-19 from getting … Read more
Malaria vaccine becomes first to achieve WHO-specified 75% efficacy goal
Researchers from the University of Oxford and their partners have reported that a malaria vaccine they are developing has proved to be 77% effective in early trials. The findings of the Phase IIb randomised, controlled, double-blind trial, posted on SSRN/Preprints with The Lancet, show the candidate malaria vaccine, R21/Matrix-M, demonstrated high-level efficacy over 12-months of … Read more
National survey reveals big reductions in COVID-19 infections with single dose of Oxford-AZ and Pfizer vaccines
Data from the national COVID-19 Infection Survey, which is led by senior NIHR Oxford BRC researcher Professor Sarah Walker, has revealed the impact of vaccination on antibody responses and new infections in a large group of adults from the general population. This major community surveillance survey, one of the NIHR’s COVID-19 urgent public health studies, … Read more
Human challenge trial launches to study immune response to COVID-19
Researchers at the University of Oxford have launched a human challenge trial to look at what kind of immune response can stop people from becoming re-infected. The team, led by the NIHR Oxford Biomedical Research Centre Director Professor Helen McShane (pictured right), also want to find out how the immune system reacts to a second … Read more
Getting Involved with the Oxford Biomedical Research Centre
The NIHR Oxford Biomedical Research Centre (BRC) has been working with a group which includes teenagers, young adults, carers and people from black, Asian and minority ethnic communities. The project is part of the development of a new strategy and had a particular focus on making health research accessible. Group members had a range … Read more
BRC’s European-funded citizen science metabolism project under way
A three-year European Commission project to fund five citizen science projects, including one run by the NIHR Oxford BRC to research metabolism, has got under way. The €2.2m STEP CHANGE project is funding citizen science projects seven European countries and one in Africa. Funded by the European Commission’s Horizon 2020 programme and coordinated by the … Read more
New clinical prediction tools for myeloma developed
University of Oxford researchers have developed new clinical prediction models for use in primary care with the aim of accelerating the diagnosis of myeloma, a cancer of the bone marrow. Myeloma caused 117,077 deaths worldwide in 2020. Earlier diagnosis improves the rate of survival but unfortunately, delays in myeloma diagnosis are common and result in … Read more
National study looks at long-term lung damage from COVID-19
A new national study involving researchers from Oxford will investigate the long-term effects of lung inflammation and scarring from COVID-19. The study, launched with £2 million of funding from UK Research and Innovation (UKRI), aims to develop treatment strategies and prevent disability. Many people recovering from COVID-19 suffer from long-term symptoms of lung damage, including breathlessness, … Read more
Oxford BRC again achieves ISO 9001 audit success
Following an external audit, the NIHR Oxford Biomedical Research Centre (BRC) has again been successfully certified to the internationally recognised ISO 9001:2015 standard. The audit of the BRC’s funding Management System was carried out by the UKAS-accredited British Assessment Bureau. Achieving the ISO 9001:2015 standard means that an organisation has excellent quality management systems in place; it also confirms a strong customer focus … Read more
Risk of severe COVID-19 from asthma and other respiratory diseases may be only modestly increased, new analysis suggests
An analysis of 8.3 million health care records in England shows that people with asthma have only a small increased risk of developing severe Covid-19. The study, led by University of Oxford researchers, examined routine patient data collected between January and April 2020 to generate risk assessments for severe COVID-19 in people with chronic respiratory … Read more
Study analyses gender parity in Oxford BRC authorship
A study conducted by NIHR Oxford Biomedical Research Centre (BRC) researchers has shown that while there are positive trends in terms of the number of women authoring the BRC’s scientific papers, the proportion of female authors is significantly lower than male ones across all categories of authorship. Nonetheless, the paper, published on the open-access online … Read more
Oxford researchers release cheap, quick COVID-19 antibody test
An international research team led by Oxford University scientists has developed a portable test for antibodies that fight the novel coronavirus that causes COVID-19. The test, which spots the presence of virus-fighting antibodies rather than a coronavirus infection, can be adapted to work on blood from a finger prick, making it quick and easy to … Read more
BRC training course prepares future healthcare research leaders
Twenty-five early and mid-career researchers and health professionals have embarked on a six-month course to give them the skills to become effective leaders in the future. The Next Generation Leaders Programme is commissioned and designed by the NIHR Oxford BRC Training and Education team to enable participants to develop key skills in leadership, conflict management … Read more
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