A new study has revealed a key mechanism by which a protein associated with Parkinson's disease damages neurons (brain cells) by blocking a vital cellular gateway. The findings help to explain how the disease begins and highlights a potential new target for treatment. Parkinson's disease, which ... READ MORE
First patient dosed in oesophageal cancer vaccine trial
An Oxford-led clinical trial has given the first patient an experimental cancer vaccine designed to help the immune system recognise and attack oesophageal (gullet) cancer. The VISTA trial, which is supported by the NIHR Biomedical Research Centre: Oxford, is testing a vaccine called ITOP1, ... READ MORE
First patient receives trial vaccine to prevent Lynch syndrome-associated cancers
The first participant has received an investigational vaccine that researchers hope will help to prevent cancer in people with Lynch syndrome (LS). The INTERCEPT-Lynch trial, which is supported by the NIHR Biomedical Research Centre: Oxford, forms part of a scientific collaboration between the ... READ MORE
Recruitment under way in ground-breaking hepatitis C study
The first stage of recruitment has begun in a University of Oxford study that will see participants infected with the hepatitis C virus – and treated – an important first step on the road to possible future testing of vaccine candidates against the disease. If untreated, hepatitis C can cause ... READ MORE
Oxford-led newborn screening pilot expanded to include all babies in England
Every newborn baby in England will be screened for spinal muscular atrophy (SMA), following the expansion of a pioneering University of Oxford-led pilot that introduced the country’s first routine test for the condition. The national evaluation programme, announced by the government ... READ MORE
University of Oxford launches trial of new Ebola vaccine
Vaccine researchers at the University of Oxford have launched the world’s first clinical trial of a vaccine against the Bundibugyo species of Ebola virus, in response to the ongoing outbreak in the Democratic Republic of the Congo and neighbouring Uganda. Conducted in Oxford, the Phase I ... READ MORE
World-first perfused pancreas transplant marks major milestone
University of Oxford researchers have carried out the world’s first successful transplantation of a perfused human pancreas, a major advance in efforts to improve organ preservation for transplantation. The preclinical work was supported by the NIHR Biomedical Research Centre: Oxford. The ... READ MORE
OUH healthcare professionals embark on research career
Six Oxford University Hospitals healthcare professionals have completed the first stage of their research journey by presenting the research projects they have undertaken on the NIHR BRC: Oxford internship programme. Every year, the NIHR Biomedical Research Centre: Oxford (BRC) makes funds ... READ MORE
AI tool reveals hidden organ damage caused by high blood pressure
Researchers at the University of Oxford have developed an artificial intelligence (AI) tool that may help doctors better understand how high blood pressure damages different organs in different people - potentially paving the way for more personalised treatment in future. The ... READ MORE
Nurses and doctors – three OUH nurses complete doctoral studies
Three Oxford University Hospitals (OUH) nurses have graduated from their doctoral programmes at Oxford Brookes University, boosting the number of doctoral-prepared nurses at OUH. Dr Carol Forde-Johnston, Recruitment and Retention Nurse Lead in the NOTSSCAN division, Dr Lian Lee, Deputy Matron ... READ MORE
Kneecap resurfacing should be standard procedure during knee replacement, study finds
The largest clinical trial of its kind has found that resurfacing the kneecap during total knee replacement is likely to be the most cost-effective approach for patients and healthcare systems in the long term. Researchers from the Universities of Oxford and Aberdeen followed more than 1,700 ... READ MORE
Decades-old puzzle solved as scientists uncover cause of inflammatory bowel disease
Scientists have identified the missing link between a long-known genetic signal in inflammatory bowel disease (IBD) and a damaging immune response that switches off the body’s natural control of inflammation - opening the door to faster diagnosis and targeted treatment. The discovery of this ... READ MORE
BRC celebrates its support for career development achievements
The NIHR Biomedical Research Centre: Oxford has held its first Academic Career Development Symposium, attended by a wide range of researchers who have benefitted from BRC support. The event, held at St Anne’s College in Oxford, featured research presentations, inspiring career talks, and poster ... READ MORE
Study reveals core biological pathways underlying osteoarthritis
A major international study led by researchers at the Kennedy Institute of Rheumatology at the University of Oxford has found that osteoarthritis (OA) – the most common form of arthritis worldwide – is not a collection of separate diseases, as many scientists had previously speculated, but rather a ... READ MORE
Visitors flock to annual showcase of Oxford’s research
Oxford’s annual Health Research Showcase, which brings researchers from many disciplines together with members of the public, attracted hundreds of half-term visitors to Oxford’s Westgate Centre on 28 May. The event, organised by Oxford’s two NIHR Biomedical Research Centres (BRC), is aimed at ... READ MORE
Blood stem cells can ‘remember’ inflammation, study reveals
Researchers have discovered that some human blood stem cells retain a lasting ‘memory’ of inflammation, a finding that could help explain links between ageing, chronic disease and blood cancers. The study, published in Nature, identifies a previously unknown subset of blood stem cells that are ... READ MORE
For its 20th anniversary, let’s celebrate the NIHR’s long-term investment in research infrastructure
Blog by Professor Helen McShane, Director of the NIHR Biomedical Research Centre: Oxford This year marks the 20th anniversary of the National Institute for Health and Care Research (NIHR). Its creation was a landmark moment; not only did it establish a system for funding high quality research in ... READ MORE
Oxford scientists devise method to speed up diagnosis of bloodstream infections
Scientists in Oxford have developed a faster way to identify the organisms causing bloodstream infections and to predict antibiotic resistance using rapid DNA sequencing, a move that could improve the care of sepsis patients in hospital and reduce unnecessary antibiotic use. Up to 245,000 ... READ MORE
International study reveals how our genes shape blood proteins linked to disease
Oxford researchers have taken part in one of the largest studies to date exploring how genetic differences influence the proteins circulating in our blood, offering new clues about why diseases develop and where new treatments might be found. Large-scale genetic studies have been conducted for ... READ MORE
Heart scan and blood test found to improve risk prediction for inherited heart condition
A large international study has identified a new model for predicting outcomes for the inherited heart condition, hypertrophic cardiomyopathy (HCM), the most frequent cause of sudden cardiac death in younger people. The findings, published in the Journal of the American Medical Association, ... READ MORE
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