A study by Oxford University researchers has found that liver problems are common among patients with COVID-19. Patient data revealed that baseline hypoalbuminemia (an possible indication that the liver is producing low levels of albumin) and rising alkaline phosphatase (ALP), which can be a sign of liver damage, could be prognostic markers for death. However, the … Read more
Oxford studies benefit from government funding of long COVID research
Thousands of people suffering with long COVID will benefit from new research programmes backed by £19.6 million to help better understand the condition, improve diagnosis and find new treatments. Among the 15 studies that will receive government funding through the National Institute for Health Research (NIHR) is the EXPLAIN study, supported by the NIHR Oxford … Read more
COVID-19 risk prediction tool wins national award
A COVID-19 risk prediction tool, developed with support from the NIHR Oxford Biomedical Research Centre (BRC) has won the Florence Nightingale Award for Excellence in Healthcare Data Analytics. The QCovid® COVID-19 Population Risk Assessment tool was developed by a cross-organisational team and rolled across NHS England. Awarded jointly by the Health Foundation and the Royal … Read more
Oxford Cancer launched at the University of Oxford
Oxford Cancer has been launched to represent and coordinate cancer research in Oxford. The pan-divisional initiative has been launched at the University of Oxford, bringing together the collective force of cancer research, outreach and care that happen across the city. With more than 900 cancer-related researchers across five Oxford University Hospitals (OUH) and University divisions, … Read more
Antiviral drug could be given to more chronic hepatitis B patients, study finds
A study by Oxford University researchers has found that the antiviral drug TDF may benefit a greater number of patients with chronic hepatitis B virus, and that those who are untreated may be at greater risk of liver inflammation and fibrosis. The research was carried out under the auspices of the National Institute for Health … Read more
“Modest” increase in heart attack hospitalisation rates after years of decline
The burden of hospital admission rates due to heart attacks in England rose between 2012 and 2016, despite decades of falling rates, new research suggests. The researchers also found that after 2010-2011, admission rates increased in most age groups. Young women aged 35 to 49 and even younger men aged 15 to 34 were the … Read more
AI replaces contrast dye for fast, cheaper and needle-free cardiac MRI scans
A team from Oxford comprising artificial intelligence (AI) scientists, magnetic resonance specialists and cardiologists have developed a new cardiac magnetic resonance (CMR) scan for detecting heart muscle disease. The current ‘gold standard’ for imaging heart muscle disease is CMR, using a method called late gadolinium enhancement. This requires injection of a contrast agent into the … Read more
New Senior Research Fellows named
The NIHR Oxford BRC has announced the appointment of its latest group of Senior Research Fellows – the third cohort of emerging research leaders to receive the accolade. Like in 2020, this year’s selection process was a coordinated effort by the Oxford BRC and its partners in the NIHR Oxford Health BRC, which focuses on mental health … Read more
Study investigating targeted drug delivery by focused ultrasound for pancreatic cancer opens
University of Oxford researchers have begun recruitment to a study looking at whether chemotherapy medication can reach pancreatic tumours more effectively if encapsulated within a heat-sensitive shell and triggered with focused ultrasound. The Phase I PanDox study, which is supported by the NIHR Oxford Biomedical Research Centre (BRC), aims to learn if using thermosensitive liposomal … Read more
Delayed second dose and third doses of the Oxford vaccine lead to heightened immune response to COVID-19
A longer delay of up to 45 weeks between the first and second dose of the Oxford-AstraZeneca vaccine leads to enhanced immune response after the second dose, the latest research by the Oxford Vaccine Group has found. They also found that a third dose given more than six months after the second dose leads to … Read more
Major grant to strengthen research and benefit patients
Oxford University Hospitals (OUH) has made a grant of £11.5 million to the University of Oxford, which the University will match with other funding, to allow the development of major clinical research facilities which have the potential to support the introduction of innovative and ground-breaking treatments for patients. Oxford is one of the most vibrant … Read more
Latest data on immune response to COVID-19 reinforces need for vaccination
A new study led by University of Oxford has found that previous infection, whether it was symptomatic or asymptomatic, does not necessarily protect you long term from COVID-19, particularly against new variants of concern. The PITCH Study (Protective Immunity from T cells to COVID-19 in Health workers) examined how the immune system responds to COVID-19 … Read more
Impaired antibody response to COVID-19 vaccination in patients with myeloid blood cancers
Oxford researchers have found that antibody responses to the first doses of COVID-19 vaccine in people with chronic myeloid blood cancers are not as strong as those among the general population. While this is expected to improve with the second dose, this important finding may help influence the design of future vaccination strategies, with further … Read more
Oxford wins government funding to evaluate prostate cancer detection system
A prostate cancer detection software system to help pathologists quickly identify suspicious areas of tissue, developed by the digital diagnostic company Paige, will be investigated in a multicentre clinical study led by the University of Oxford as part of a successful NHSX Artificial Intelligence Health and Care Award application. Paige Prostate automatically detects and highlights … Read more
Treating needle fears may reduce COVID-19 vaccine hesitancy
A new large-scale study shows that a quarter of the UK adult population has a potential injection phobia, and these individuals are twice as likely to be put off getting a COVID-19 vaccine. The study indicates that if all injection anxiety in the population was removed, just over 10 per cent of instances of vaccine … Read more
RECOVERY Trial identifies another effective COVID-19 treatment
The RECOVERY Trial, the world’s largest randomised trial of potential COVID-19 treatments, has found that a monoclonal antibody combination developed by US company Regeneron reduces deaths for hospitalised COVID-19 patients who have not mounted their own immune response. The RECOVERY Trial, which is led from Oxford and supported by the NIHR Oxford BRC, was established as a randomised … Read more
Professor Susan Jebb appointed as Chair of the Food Standards Agency
Professor Susan Jebb, the Oxford BRC’s Theme Lead for Obesity, Diet and Lifestyle, has been appointed as the new Chair of the Food Standards Agency. Prof Jebb, Professor of Diet and Population Health in Oxford University’s Nuffield Department of Primary Care Health Sciences, said: “I am delighted to be appointed to Chair the Food Standards … Read more
BRC-supported researchers recognised in Queen’s Birthday Honours
A number of NIHR Oxford BRC-supported researchers who have played prominent roles in the global response to the COVID-19 pandemic have been honoured as part of the Queen’s Birthday Honours List. The researchers, who have developed new vaccines or identified new drug treatments, have saved many lives around the world. Among the BRC researchers recognised … Read more
RECOVERY trial finds aspirin does not improve survival for hospitalised COVID-19 patients
The RECOVERY Trial, the world’s largest randomised trial of potential COVID-19 treatments, has found that in patients hospitalised with COVID-19, aspirin is not associated with reductions in mortality or in the risk of progressing to invasive mechanical ventilation or death. In results published on the pre-print server medRxiv, the trial team found that aspirin was associated with a small … Read more
AI endoscopy enables 3D surface measurements of pre-cancerous condition in oesophagus
Clinicians and engineers in Oxford have begun using artificial intelligence alongside endoscopy to get more accurate readings of the pre-cancerous condition Barrett’s oesophagus and so determine patients most at risk of developing cancer. In a research paper published in the journal Gastroenterology, the researchers said the new AI-driven 3D reconstruction of Barrett’s oesophagus achieved 97.2 … Read more
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