The first volunteer has received a dose in a first-in-human trial of a vaccine developed in Oxford against Lassa fever, marking a major milestone in the fight against the deadly virus. The trial, conducted by the Oxford Vaccine Group, and funded by the Coalition for Epidemic Preparedness ... READ MORE
Can AI models rival humans in anonymising patient data?
Researchers from the University of Oxford have benchmarked artificial intelligence (AI) tools capable of automatically removing personal information from patient electronic health records in a key step towards enabling large-scale, confidential medical research. As healthcare becomes digitised, ... READ MORE
Blood test predicts risk of death in acutely ill children in lower-income countries
An international study has identified a blood-based indicator of intestinal damage and inflammation that strongly predicts mortality in sick children. The new biomarker could help to identify those children at greatest risk of dying after hospitalisation in parts of the world with limited ... READ MORE
BRC senior researcher appointed to help tackle health inequalities in Oxfordshire
Dr Joanna Crocker, the NIHR Oxford Biomedical Research Centre’s Senior Researcher for Patient and Public Involvement has been appointed Chief Scientific Advisor to lead community-engaged research tackling health inequalities in Oxfordshire. Dr Crocker (pictured right) is one of three Chief ... READ MORE
Unique UK re-audit of upper gastrointestinal bleeding highlights progress
A major UK-wide audit has shown significant improvements in outcomes for patients admitted to hospital with acute upper gastrointestinal bleeding – and highlighted clear areas for further progress. This re-audit, which followed an earlier audit in 2007, was led from Oxford, conducted by experts ... READ MORE
Oxford and GSK launch Experimental Medicine Collaboration
The pharmaceutical multinational GSK is investing £10 million over five years to establish the Experimental Medicine Collaboration with the University of Oxford. The GSK and University of Oxford Experimental Medicine Collaboration (EMC) is a pioneering partnership that aims to redefine the ... READ MORE
Scientists map cells that drive Crohn’s disease fistulas, paving way for targeted treatments
Scientists at the University of Oxford, have identified how rare populations of abnormal cells drive the formation and persistence of fistulas – painful, tunnel-like tracts that develop in around 30% of people with Crohn’s disease. Crohn’s disease is a long-term disease that affects around one ... READ MORE
Oxford-led study shows vaccine protection against Paratyphoid
Results from a newly published study show that a vaccine can protect people against Salmonella Paratyphi A infection. The Oxford-led study demonstrated that an oral live-attenuated vaccine, CVD 1902, provided significant protection against S. Paratyphi A infection in healthy ... READ MORE
Almost 70% of bowel cancers missed at colonoscopy are avoidable
A major nationwide study has revealed that the majority of bowel cancers diagnosed late, after a false-negative colonoscopy could have been prevented or detected earlier. The study, published in Endoscopy, was supported by the National Institute for Health and Care Research (NIHR) Oxford ... READ MORE
World’s largest hip fracture research platform launched to improve care and outcomes
Taking an innovative approach to clinical research in hip fracture, the World Hip Trauma Evaluation (WHiTE) Platform Trial has been launched to test multiple new treatments for patients with fractures of the hip. Hip fractures are a major global health challenge, with 1.3 million cases per year ... READ MORE
Oxford team develops new national course for all UK surgical trainees
A new national online surgical research course designed to equip every surgical trainee in the UK with the skills to critically engage with, and contribute to, surgical research has been developed in Oxford. The National Online Teaching Programme (NOTP) Surgical Research Course provides core ... READ MORE
Underweight children cost NHS as much per child as those with obesity, study finds
The NHS incurs an estimated £340 million in additional healthcare costs annually due to weight-related health problems in children – but it is not just obesity driving the costs. New research from the University of Oxford reveals that underweight children need comparable medical support as ... READ MORE
Towards inclusive sleep science
An Oxford academic paper that suggests current sleep scoring criteria may lead to biased results between sexes and across age groups has been brought back into the spotlight with a recent editorial and podcast. A recent editorial by Prof Monika Haack of Harvard Medical School, published in the ... READ MORE
Oxford researchers pioneer new breathing test to detect lung disease earlier
A new project led by the University of Oxford aims to develop a novel breathing test that could detect asthma and COPD earlier, more accurately, and closer to home, reducing pressure on the NHS and improving outcomes for patients. This work is included in a portfolio of research funded by the ... READ MORE
Two world firsts in myeloma trials at OUH
Two world firsts have taken place in trials at Oxford University Hospitals to tackle the blood cancer myeloma. One of the trials is testing a new tracer to be used on myeloma patients during PET-CT scans; the other is investigating a new potential drug combination therapy. A key factor in both ... READ MORE
Levelling the medical devices playing field for all pregnant women
How can bias in the medical devices used during pregnancy and the neonatal period affect health outcomes, especially for minority ethnic and socio-economically disadvantaged groups? An Oxford University project, supported by the NIHR Oxford Biomedical Research Centre (BRC), is aiming to use the ... READ MORE
Twelve OUH staff embark on their research journey
Twelve members of the Oxford University Hospitals staff from a range of disciplines have begun their research journey by starting two schemes aimed at nurses, midwives, allied health professionals, healthcare scientists, pharmacists and clinical psychologists (NMAHPPS). Six people started the ... READ MORE
Trial shows that suture repair fails to improve digital nerve injury outcomes
The first ever trial of microsurgical suture repair versus nerve alignment for digital nerve injuries suggests suture repair does not improve outcomes. Digital nerve injuries are the most common type of nerve injury treated surgically in the UK, often caused by sharp cuts to the ... READ MORE
Study evaluates effectiveness of cancer diagnosis pathway
A major UK study has provided the most comprehensive analysis to date of a cancer diagnosis pathway for patients presenting with non-specific symptoms (NSS), such as unexplained weight loss or fatigue. These NSS can indicate a wide range of conditions, from benign diseases to late-stage ... READ MORE
National registry launched to transform care for people at risk of type 1 diabetes
A first-of-its-kind UK registry for children and adults who are at risk of type 1 diabetes has been launched at the University of Oxford. With more than £600,000 of funding from Diabetes UK, the UK Islet Autoantibody Registry aims to transform how people in the earliest stages of type 1 ... READ MORE
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