A ground-breaking study has identified a new disease-inducing mechanism for inflammatory bowel disease (IBD) in which the immune system attacks its own regulatory function. Interleukin-10 (IL10) is an anti-inflammatory protein that crucially controls intestinal immunity. Children with genetic ... READ MORE
Prediction model could help inform patients of shoulder replacement surgery risks
A new model to predict the risk of serious complications after shoulder replacement surgery has been developed in a collaboration between researchers from Oxford, Bristol and Copenhagen. The model could be an important tool to help patients and doctors make more informed decisions about this common ... READ MORE
Patient story – Kathryn Hedigan, EXPLAIN study
Kathryn Hedigan took part in the EXPLAIN study, which used hyperpolarised xenon MRI scans to investigate possible lung damage in long COVID patients who had not been hospitalised with COVID-19 but who continued to experience breathlessness. Kathryn, aged 66, lives near Burford in West ... READ MORE
Workshop explores CRISPR gene editing potential
The NIHR Oxford BRC’s Gene and Cell Therapy Theme has organised its second workshop to discuss how researchers from a range of disciplines are using new CRISPR gene editing tools or applying CRISPR to their research in innovative ways. The workshop, held on 4 July at Merton College in Oxford, ... READ MORE
BRCs showcase breadth of Oxford’s research
Researchers from Oxford’s two NIHR Biomedical Research Centres (BRC) took over the city’s Westgate Centre on Thursday 30 May to showcase the world-class healthcare research they are carrying out an their annual Open Day. Hundreds of half-term visitors, including a large number of children, were ... READ MORE
Study outlines feasibility of multiple disease risk prediction model for primary care
A team of researchers have found that a single, integrated health check carried out in a primary care setting can accurately predict risks for diseases across multiple organs. Currently, GPs are often limited to assessing the risk of diseases one at a time, a process that is ... READ MORE
Hiding in plain sight: study identifies cryptic disease-causing genetic variants not detected by standard testing
Researchers in Oxford have identified types of genetic variants that lead to a range of rare disease but are not picked up by standard genetic testing. The team at the University of Oxford’s Centre for Human Genetics analysed whole genome sequencing data from the 100,000 Genomes Project. They ... READ MORE
Importance of early blood glucose control for people with type 2 diabetes highlighted
Research led by scientists from the Universities of Oxford and Edinburgh has found that early good blood glucose control can minimise the lifetime risk of diabetes-related complications, including heart attacks, kidney failure and vision loss. These latest results from the UK Prospective ... READ MORE
Study identifies ways cancer treatment may lead to harmful side effects
A team of University of Oxford researchers have identified potential pathways by which cancer treatment can cause colitis. Checkpoint inhibitors (CPIs) are a type of cancer treatment that help the immune system fight cancer by removing some of its restraints. However, these treatments ... READ MORE
New Maternity Early Warning Score to be implemented across the NHS
Researchers in Oxford have developed a new maternity early warning score that is derived from patient data. The new system, which is being rolled out across the English NHS, will help healthcare providers identify and respond to signs of deterioration in pregnant women. Maternity Early Warning ... READ MORE
Funding announced for hepatitis C controlled human infection model trial
A proposed groundbreaking study that will see participants infected with hepatitis C - and treated - has secured more than £1million in funding. The study will help pave the way for future testing of hepatitis C vaccine candidates. The £1,098,103 funding from the research and grant-making ... READ MORE
Two OUH nurses chosen for national research leadership programme
Two nurses from Oxford University Hospitals have been appointed to a national programme aimed at fostering a culture of research amongst nurses and midwives. Dr Louise Strickland and Dr Clair Merriman were appointed to the National Institute of Health and Care Research’s (NIHR) Senior Research ... READ MORE
New study to improve vaccines and therapeutics development
A first-of-its-kind study led by the University of Oxford has successfully investigated human immunity against COVID-19 in people who already have antibodies against it. The results suggest that previous infection, together with vaccination, offers strong protection against the original ... READ MORE
Study sheds light on debate around shoulder replacement surgery for osteoarthritis
A new study has provided valuable insights into the ongoing debate surrounding two types of shoulder replacement surgery as a treatment for patients with osteoarthritis: reverse total shoulder replacement and anatomical total shoulder replacement. The study, published in the BMJ and funded by ... READ MORE
NHS baby check may miss dislocated hips in new-born babies
A new study has identified that NHS infant checks can miss serious hip abnormalities in new-born babies. Left undetected, these can require complex surgery, and lead to early arthritis. The study, published by the JAMA Network, was led by researchers at the University of Liverpool in ... READ MORE
Breakthrough aerosol human infection model gives hope for future TB vaccine development
University of Oxford researchers have for the first time established a controlled human infection model for tuberculosis (TB) that infects people via the lungs – the way TB enters the body. The clinical trial, which used the BCG vaccine delivered via aerosol into participants’ lungs, is a first ... READ MORE
Recipients of BRC doctoral funding present PhD projects
Six Oxford University Hospitals (OUH) nurses and allied health professionals who have received funding from NIHR Oxford Biomedical Research Centre (BRC) have presented their PhD projects to their fellow awardees and supervisors. The BRC provides up to £10,000 for the year to give the recipients ... READ MORE
New study reveals long-term mental health risks after COVID-19
A new study has shed light on the long-term mental health consequences of COVID-19 infection and the growing evidence of the protective effect of vaccination on reducing the risk. The research, supported by the NIHR Oxford Biomedical Research Centre (BRC), was conducted in a population-based ... READ MORE
Study assesses new MRI technique to detect liver cancer
Oxford researchers have been awarded funding to conduct a study comparing a new type of MRI (Magnetic resonance imaging) to standard of care ultrasound for liver cancer surveillance in people with cirrhosis. The University of Oxford’s DeLIVER team, which is investigating early detection methods ... READ MORE
Oxford BRC researcher named NIHR Senior Investigator
NIHR Oxford BRC researcher Professor Ronjon Chakraverty has received a prestigious national research award. Professor Chakraverty, Professor of Haematology in the Radcliffe Department of Medicine and Oxford BRC Co-theme Lead for Gene and Cell Therapy, was named a National Institute of Health ... READ MORE
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