Respiratory researchers in Oxford have discovered a link between potentially pathogenic bacteria and airways inflammation in severe asthma. The team, who are supported by the NIHR Oxford Biomedical Research Centre (BRC), used long-read genome sequencing on sputum and nasal lavage samples from ... READ MORE
Research profile: using research to answer clinical questions
Rebecca Bone has been a consultant nurse in heart failure at Oxford University Hospitals for two years, and throughout her research journey, she has received support from the NIHR Oxford Biomedical Research Centre (BRC). Rebecca finished her Masters in 2017 and was encouraged by her dissertation ... READ MORE
BLOG: How we’ve succeeded in recruiting older hospital patients onto our trial
Professor Sarah Pendlebury, from the NIHR Oxford BRC’s Preventive Neurology Theme, and Dr Aubretia McColl, of the Wolfson Centre for Prevention of Stroke and Dementia, explain how they have tackled the challenge of recruiting older, frail patients with multiple conditions to trials within ... READ MORE
Dr Clement Twumasi – underpinning our research with statistical expertise
Dr Clement Twumasi is an Oxford BRC-supported medical statistician whose role involves providing a range of statistical support for clinical trials and other vaccine-related studies, as well as assisting with funding applications. Based at the University of Oxford’s Nuffield Department of ... READ MORE
Study reveals previously unknown genetic causes of colorectal cancer
A pioneering study has provided the most comprehensive analysis to date of the genetic make-up of colorectal cancer. The study, which was supported by the NIHR Oxford Biomedical Research Centre, involved the Universities of Oxford, Manchester, Birmingham, Edinburghand Leeds, The Institute of ... READ MORE
Research identifies autoimmunity against a key anti-inflammatory regulator in IBD
A ground-breaking study has identified a new disease-inducing mechanism for inflammatory bowel disease (IBD) in which the immune system attacks its own regulatory function. Interleukin-10 (IL10) is an anti-inflammatory protein that crucially controls intestinal immunity. Children with genetic ... READ MORE
Prediction model could help inform patients of shoulder replacement surgery risks
A new model to predict the risk of serious complications after shoulder replacement surgery has been developed in a collaboration between researchers from Oxford, Bristol and Copenhagen. The model could be an important tool to help patients and doctors make more informed decisions about this common ... READ MORE
Patient story – Kathryn Hedigan, EXPLAIN study
Kathryn Hedigan took part in the EXPLAIN study, which used hyperpolarised xenon MRI scans to investigate possible lung damage in long COVID patients who had not been hospitalised with COVID-19 but who continued to experience breathlessness. Kathryn, aged 66, lives near Burford in West ... READ MORE
Workshop explores CRISPR gene editing potential
The NIHR Oxford BRC’s Gene and Cell Therapy Theme has organised its second workshop to discuss how researchers from a range of disciplines are using new CRISPR gene editing tools or applying CRISPR to their research in innovative ways. The workshop, held on 4 July at Merton College in Oxford, ... READ MORE
BRCs showcase breadth of Oxford’s research
Researchers from Oxford’s two NIHR Biomedical Research Centres (BRC) took over the city’s Westgate Centre on Thursday 30 May to showcase the world-class healthcare research they are carrying out an their annual Open Day. Hundreds of half-term visitors, including a large number of children, were ... READ MORE
Study outlines feasibility of multiple disease risk prediction model for primary care
A team of researchers have found that a single, integrated health check carried out in a primary care setting can accurately predict risks for diseases across multiple organs. Currently, GPs are often limited to assessing the risk of diseases one at a time, a process that is ... READ MORE
Hiding in plain sight: study identifies cryptic disease-causing genetic variants not detected by standard testing
Researchers in Oxford have identified types of genetic variants that lead to a range of rare disease but are not picked up by standard genetic testing. The team at the University of Oxford’s Centre for Human Genetics analysed whole genome sequencing data from the 100,000 Genomes Project. They ... READ MORE
Importance of early blood glucose control for people with type 2 diabetes highlighted
Research led by scientists from the Universities of Oxford and Edinburgh has found that early good blood glucose control can minimise the lifetime risk of diabetes-related complications, including heart attacks, kidney failure and vision loss. These latest results from the UK Prospective ... READ MORE
Study identifies ways cancer treatment may lead to harmful side effects
A team of University of Oxford researchers have identified potential pathways by which cancer treatment can cause colitis. Checkpoint inhibitors (CPIs) are a type of cancer treatment that help the immune system fight cancer by removing some of its restraints. However, these treatments ... READ MORE
New Maternity Early Warning Score to be implemented across the NHS
Researchers in Oxford have developed a new maternity early warning score that is derived from patient data. The new system, which is being rolled out across the English NHS, will help healthcare providers identify and respond to signs of deterioration in pregnant women. Maternity Early Warning ... READ MORE
Funding announced for hepatitis C controlled human infection model trial
A proposed groundbreaking study that will see participants infected with hepatitis C - and treated - has secured more than £1million in funding. The study will help pave the way for future testing of hepatitis C vaccine candidates. The £1,098,103 funding from the research and grant-making ... READ MORE
Two OUH nurses chosen for national research leadership programme
Two nurses from Oxford University Hospitals have been appointed to a national programme aimed at fostering a culture of research amongst nurses and midwives. Dr Louise Strickland and Dr Clair Merriman were appointed to the National Institute of Health and Care Research’s (NIHR) Senior Research ... READ MORE
New study to improve vaccines and therapeutics development
A first-of-its-kind study led by the University of Oxford has successfully investigated human immunity against COVID-19 in people who already have antibodies against it. The results suggest that previous infection, together with vaccination, offers strong protection against the original ... READ MORE
Study sheds light on debate around shoulder replacement surgery for osteoarthritis
A new study has provided valuable insights into the ongoing debate surrounding two types of shoulder replacement surgery as a treatment for patients with osteoarthritis: reverse total shoulder replacement and anatomical total shoulder replacement. The study, published in the BMJ and funded by ... READ MORE
NHS baby check may miss dislocated hips in new-born babies
A new study has identified that NHS infant checks can miss serious hip abnormalities in new-born babies. Left undetected, these can require complex surgery, and lead to early arthritis. The study, published by the JAMA Network, was led by researchers at the University of Liverpool in ... READ MORE
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