The first participants in a clinical trial of a bioelectrical therapy to treat incontinence have received their 'smart' bioelectronic implants. Amber Therapeutics, a University of Oxford spin-out company developing intelligent bioelectrical therapies, applied the Picostim-DyNeuMo research ... READ MORE
An open book? New genetic mutation linked to rare conditions
Researchers have discovered that a rare type of genetic variant can be responsible for two well-known skeletal disorders. Whereas many genetic conditions are caused by structural variations that involve deletions, insertions or duplications of segments of DNA, the scientists found that the ... READ MORE
Oxford BRC to be given Freedom of Oxford
The NIHR Oxford Biomedical Research Centre (BRC) is to be given the Freedom of the City of Oxford. The award is the highest honour Oxford City Council can bestow and has previously been given to dignitaries including Oxfam, Nelson Mandela, authors Philip Pullman and Colin Dexter, and Sir Roger ... READ MORE
New imaging centre officially opened
A new Acute Multidisciplinary Imaging and Interventional Centre (AMIIC), based at the John Radcliffe Hospital, has been officially opened. AMIIC, part of the University of Oxford’s Radcliffe Department of Medicine, was previously known as AVIC (Acute Vascular Imaging Centre). The newly ... READ MORE
National guidelines produced on use of genomics in treatment of IBD
National guidelines have been developed for clinicians on the use of genomics to diagnose and care for patients with monogenic inflammatory bowel disease (IBD), a group of intestinal disorders caused by variations in a single gene. The new guidelines, unveiled in an article in the Lancet ... READ MORE
Better diagnosis and treatment of autoimmune diseases a step closer
A study involving Oxford researchers has outlined a way to find the crucial peptides (protein fragments) that drive autoimmunity, as well as the immune cells that respond to it. On a fundamental level, in autoimmune diseases immune cells mistake healthy cells for infected cells. Finding the ... READ MORE
Professor Marian Knight recognised for services to maternal and public health
Professor Marian Knight, the Oxford Biomedical Research Centre’s Co- Theme Lead for Cardiovascular Medicine, has been recognised in the New Year Honours list 2023. She was appointed Member of the Order of the British Empire (MBE) for services to Maternal and Public Health. Professor ... READ MORE
Genetic ‘marker’ linked to side-effects from skin cancer treatment found
New research has identified a genetic marker that could be used to predict a patient’s risk of developing serious side-effects when undergoing immunotherapy treatment for one of the most common skin cancers. The study, which was supported by the NIHR Oxford Biomedical Research Centre ... READ MORE
No benefit found in switching to citrate anticoagulation for ICU kidney injury treatment
New research has found no added benefit of using citrate-based drugs in the treatment of acute kidney disease in intensive care, when compared to the anticoagulation drug heparin, despite their extra cost. People with acute kidney injury (when the kidneys stop working correctly) may need a ... READ MORE
Adalimumab found to be cost-effective treatment for early-stage Dupuytren’s disease
Oxford researchers supported by the Oxford BRC have found that the anti-TNF treatment adalimumab is likely to be a cost-effective treatment for people affected by early-stage Dupuytren’s disease. Anti-TNF treatments interfere with the action of a protein called tumour necrosis factor (TNF) and ... READ MORE
Patient and public involvement contributors prepare for launch of new BRCs
Patient and public contributors have gathered with researchers in Oxford to discuss how patient and public involvement and engagement (PPIE) can be enhanced and play a bigger role in the new NIHR Biomedical Research Centres (BRC) when they begin next month. The workshop at St Catherine’s ... READ MORE
Oxford researcher investigates genetic mechanisms of rare forms of asthma
An Oxford researcher has been awarded funding to expand her cutting edge research into the genetic mechanisms of rare and severe forms of asthma. Dr Anastasia Fries, NIHR Academic Clinical Fellow in Respiratory Medicine, was awarded a three-year MRC Clinical Research Training Fellowship worth ... READ MORE
BRC sponsors Black History Month talk by anti-apartheid veteran
The Oxford Biomedical Research Centre has sponsored a talk organised a talk by Oxford University Hospitals BAME network as part of Black History Month. The talk on Wednesday 12 October was by Chris Lubbe, anti-apartheid activist and former bodyguard of the late South African President Nelson ... READ MORE
Oxford BRC gets £86.6m funding for healthcare research
Health and care research in Oxford is to receive £122 million in government funding over the next five years to improve diagnosis, treatment and care for NHS patients. The funding was awarded to the city’s two National Institute for Health and Care Research (NIHR) Biomedical Research Centres ... READ MORE
Oxford researchers to study why asthma is worse in women
A University of Oxford team has been awarded a grant to study one of the major unsolved questions about asthma – why women are more likely to have it than men and why they are twice as likely to die from it. Bioinformatician Dr Emanuele Marchi has received £98,000 from the national charity ... READ MORE
New computational technique reveals changes to lung function after COVID-19 infection
A study led by Oxford researchers has found that prior COVID-19 infection is associated with more uneven inflation of the lungs during normal breathing. There was also an association between hospitalisation with COVID-19 and smaller lung volumes, and admission to the intensive care unit (ICU) was ... READ MORE
One in eight people have undiagnosed nighttime hypertension
Around 15 percent of people aged between 40 and 75 may have a form of undiagnosed high blood pressure (hypertension) that occurs only at nighttime. Because they do not know about this, and are therefore not being treated for it, they are at a higher risk of cardiovascular disease such as ... READ MORE
Next generation of research leaders complete BRC programme
Aspiring healthcare research leaders have successfully completed the latest Oxford BRC Next Generation Leaders Programme, with the 16 course participants presenting the quality improvement projects they had been working on. This is the third edition of the Next Generation Leaders Programme, ... READ MORE
Malaria booster vaccine continues to meet WHO efficacy goal
Researchers from the University of Oxford and their partners have reported new findings from their Phase 2b trial which tested the effectiveness of a booster dose of their candidate malaria vaccine. The vaccine, R21/Matrix-M, had previously demonstrated high-level efficacy of 77 ... READ MORE
OUH clinical staff awarded funding for research skills training
OUH clinical staff awarded funding for research skills training Thirteen Oxford University Hospitals (OUH) nurses, midwives, allied health professionals and research practitioners have received funding to develop skills that will support them to research new and improved ways of delivering ... READ MORE
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