NIHR Oxford Biomedical Research Centre

Enabling translational research through partnership

MENUMENU
  • About
    • About the NIHR Oxford Biomedical Research Centre
    • Activities during COVID-19
    • Strategic Partnership Board
    • Steering Committee
    • Promoting Equality, Diversity and Inclusion in Research
    • Current Vacancies
    • Contact Us
    • Stay in Touch
  • Research
    • Research Themes Overview
    • Cancer
    • Cardiovascular Medicine
    • Digital Health from Hospital to Home
    • Gene and Cell Therapy
    • Genomic Medicine
    • Imaging
    • Inflammation across Tissues
    • Life-saving Vaccines
    • Metabolic Experimental Medicine
    • Modernising Medical Microbiology and Big Infection Diagnostics
    • Musculoskeletal
    • Preventive Neurology
    • Respiratory Medicine
    • Surgical Innovation, Technology and Evaluation
    • Translational Data Science
  • Patient & Public Involvement
    • Getting involved with research
    • View and register for involvement opportunities
    • Patient & Public Groups
    • Patient and Public Involvement Advisory Group
    • Diversity in Research Group
    • Oxford Blood Group
    • Case Studies
    • PPIE Strategy
    • PPIE News
    • PPI Researcher Guidance
    • Researchers: Post a PPIE opportunity
  • Training Hub
    • Training Hub Overview
    • Clinical Academic Pathway
    • Internships
    • Preparatory Research Fellowships
    • Senior Research Fellowships
    • Research Training Bursaries
    • Doctoral Awards
    • Post-Doctoral Awards
    • Other funding
    • Leadership Training
    • Useful Links
    • Training and Education Resources
    • Upcoming Training Events & Courses
  • Industry
    • Collaborate with Oxford BRC
    • Who Do We Work With?
    • Events
    • Further Information and Additional Resources
    • Contacts for Industry
  • Videos
  • News
  • Events
Research Theme

Modernising Medical Microbiology and Big Infection Diagnostics

Home > Research Themes Overview > Modernising Medical Microbiology and Big Infection Diagnostics > Infections in Oxfordshire Research Database > IORD Projects

IORD – Ongoing approved projects and project outputs

  • IORD Categories

  • Order by

  • Search

Analysis of trends in mortality rates following infection with SARS-CoV-2 in patients with underlying haemato-oncology diagnoses at Oxford University Hospitals

ONGOING
IORD category: Antimicrobial Resistance and Antibiotics, Electronic Health Records
Chief Investigator: Prof David Eyre · Sponsor: OUH · Research location: OUH NHS Trust · Approval date: 11 Nov 2022

Antimicrobial resistance is a growing threat to public health worldwide. In hospitals, if antibiotics do not treat severe infections effectively this can lead to more deaths and longer hospital stays. However, prompt adjustments to antibiotic treatments to switch to an antibiotic that works may ... READ MORE

Ranges of laboratory test results observed in hospitalised neonates

ONGOING
IORD category: Electronic Health Records
Chief Investigator: Professor Sarah Walker · Sponsor: OUH · Research location: Oxford University · Approval date: 02 Jul 2019

Neonatal sepsis is a major cause of death in infants and young children in low-income and middle-income countries. There is increasing concern that rising antimicrobial resistance is reducing the effectiveness of recommended antibiotic treatments. New studies are being set-up to test new approaches ... READ MORE

Impact of weight and renal function on antibiotic doses received, and potential impact on CRP response

COMPLETED
IORD category: Electronic Health Records
Chief Investigator: Prof Sarah Walker · Sponsor: OUH · Research location: Oxford University · Approval date: 02 Jul 2019

Antibiotics are mainly old drugs that have been in use for many years. The doses of antibiotics we use to treat infections were mainly worked out using older methods in the 1960s-1980s. Often one fixed dose is used in adults with normal kidney function, and this dose is reduced in adults with poorer ... READ MORE

Recording of routine physiological measurements and potential for impact on analyses of electronic health records

COMPLETED
IORD category: Electronic Health Records
Chief Investigator: Prof Sarah Walker · Sponsor: OUH · Research location: Oxford University · Approval date: 02 Jul 2019

Increasingly detailed electronic health records are available and being used to try to work out how to improve management and outcomes in hospitals. However, these data are not always recorded accurately, and the impact of this on how they should best be used is unknown. We plan to look at ... READ MORE

Examining the independent predictive value of acute kidney injury among patients with and without infection on outcome in the Oxford University Hospitals NHS Foundation Trust

ONGOING
IORD category: Electronic Health Records
Chief Investigator: Dr Doreen Zhu · Sponsor: OUH · Research location: Oxford University · Approval date: 29 Mar 2019

Acute kidney injury (AKI) is a sudden reduction in kidney function (commonly caused by infections and other illnesses) and occurs in about one-fifth of patients admitted to hospital. Compared to admissions not complicated by AKI, hospitalisation with AKI has been associated with longer stay and ... READ MORE

Using unsupervised computational methods on electronic health records, to identify changes in underlying infrastructure or data quality over time

ONGOING
IORD category: Electronic Health Records
Chief Investigator: Phuong Quan · Sponsor: OUH · Research location: Oxford University · Approval date: 29 Mar 2019

Electronic health records (EHR) are increasingly being used to conduct epidemiological research but there is little awareness or guidance regarding appropriate methods to check the validity of using such data when it spans long time periods.  Many things which contribute to how and what data is ... READ MORE

The impact of patients presenting with fever on Emergency Department and Hospital performance in Oxfordshire

COMPLETED
IORD category: Electronic Health Records
Chief Investigator: Prof Tim Peto · Sponsor: OUH · Research location: Oxford University · Approval date: 07 Nov 2018

Fever is an important sign of infection and can be used to work out how to manage patients after they arrive at a hospital Emergency Department (ED) (called a “care pathway”). Often, patients with fever need specific tests or may even be admitted to hospital straightaway (for example if sepsis is ... READ MORE

Frequency of test requests from Primary Care to Clinical Microbiology

COMPLETED
IORD category: Electronic Health Records
Chief Investigator: Dr Gail Hayward, Dr Thomas Fanshawe · Sponsor: OUH · Research location: Oxford University · Approval date: 18 May 2018

A large number of companies making tests to diagnose infections are aiming to design tests which will be used by GPs in community settings. These rapid tests can give a single result to help doctors decide if an infection is present, or can perform a combination of different tests on a single ... READ MORE

C-reactive protein test in children

ONGOING
IORD category: Electronic Health Records
Chief Investigator: Dr Gea Holtman; Prof Ann van den Bruel · Sponsor: OUH · Research location: Oxford University · Approval date: 05 Jan 2018

The C-reactive protein (CRP) test is used by clinicians in various health care settings. CRP is an acute phase protein released into the blood during an infection or inflammation. There is an increase in the use of CRP test in primary care, accident and emergency departments and outpatient clinics. ... READ MORE

Emergency hospital readmissions: determinants, weekend effect and time-trend

COMPLETED
IORD category: Electronic Health Records
Chief Investigator: Dr Julia Pakpoor · Sponsor: OUH · Research location: Oxford University · Approval date: 12 Oct 2017

Re-admissions are instances where patients are admitted to hospital within a short period of time after having been sent home from a previous hospital admission. Re-admissions have been thought to reflect poor hospital care, with a potential negative impact on patient health. They are expensive for ... READ MORE

Delayed discharges in hospitalized elderly patients: complications, mortality and time-trend

COMPLETED
IORD category: Electronic Health Records
Chief Investigator: Dr Julia Pakpoor · Sponsor: OUH · Research location: Oxford University · Approval date: 12 Oct 2017

A delayed discharge occurs when a patient remains in hospital after having been declared medically fit to return home from a hospital admission. Patients may remain in hospital for reasons other than medical need due to for example delays in finding appropriate placements for community care, need to ... READ MORE

What is driving increases in paediatric A&E attendances?

COMPLETED
IORD category: Electronic Health Records
Chief Investigator: Prof Sarah Walker · Sponsor: OUH · Research location: Oxford University · Approval date: 25 Feb 2015

The numbers of children coming to A&E have steadily increased over the last 5 years, and are continuing to increase. This puts a large burden on NHS staff. However, the reasons behind this increase are not entirely clear. Parents may be bringing children who are less sick because they struggle ... READ MORE

Can we identify surgical site infections using routine electronic health record data?

ONGOING
IORD category: Electronic Health Records, Specific Infections
Chief Investigator: Prof Sarah Walker · Sponsor: OUH · Research location: Oxford University · Approval date: 25 Feb 2015

Millions of operations are carried out in the NHS every year. Infection is a rare but important complication that can happen after surgery. Specific operations are routinely monitored every year in every NHS hospital to see how often these post-surgery infections occur. This is very time-consuming ... READ MORE

Trends in bacterial pathogens, antibiotic resistance, antibiotic usage and patient outcomes in critical care in the Oxford University NHS Trust hospitals, 1999-2014

COMPLETED
IORD category: Antimicrobial Resistance and Antibiotics, Electronic Health Records, Specific Pathogens
Chief Investigator: Dr Nicole Stoesser · Sponsor: OUH · Research location: Oxford University · Approval date: 12 Jan 2015

Antibiotics are medicines that are hugely important in treating many infections, and antibiotic resistance is a major clinical problem. Research has shown that increased use of antibiotics, whether appropriate or inappropriate, seems to be associated with higher numbers of antibiotic-resistant ... READ MORE

Outcomes after elective surgery: prognostic information in baseline blood tests

COMPLETED
IORD category: Electronic Health Records
Chief Investigator: Dr David Wyllie · Sponsor: OUH · Research location: OUH NHS Trust · Approval date: 04 Jul 2014

Although relatively rare (under 5%), surgical site infections are the most common complication of planned operations (hospital admissions for what is termed “elective surgery”). Other complications (such as needing to be re-operated on, or even dying) are also rare, but may also be related to ... READ MORE

To what extent do urine cultures provide prognostic information for poor outcomes?

COMPLETED
IORD category: Electronic Health Records
Chief Investigator: Phuong Quan · Sponsor: OUH · Research location: OUH NHS Trust · Approval date: 03 May 2013

Urine cultures are the most commonly performed microbiology test at the Oxford University Hospitals but clinical impression is that many of these tests may be unnecessary. IORD provides an opportunity to see if we can answer clinical questions about the value of tests such as urine cultures for ... READ MORE

Understanding the causes of changes in severity biomarkers

COMPLETED
IORD category: Electronic Health Records
Chief Investigator: Dr David Wyllie · Sponsor: OUH · Research location: OUH NHS Trust · Approval date: 21 Oct 2011

... READ MORE

Statistical Network Modelling of Ward Transfer Patterns and their Relationship to Hospital Acquired Infections

COMPLETED
IORD category: Electronic Health Records, Specific Infections
Chief Investigator: John Finney · Sponsor: OUH · Research location: OU Dept of Statistics · Approval date: 22 Jul 2011

... READ MORE

Asymptomatic carriage candidate selection

COMPLETED
IORD category: Electronic Health Records
Chief Investigator: John Finney · Sponsor: OUH · Research location: OUH NHS Trust · Approval date: 22 Jul 2011

... READ MORE

Panoramic view of the John Radcliffe Hospital infection networks

COMPLETED
IORD category: Electronic Health Records
Chief Investigator: Mr John Finney · Sponsor: OUH · Research location: OUH NHS Trust · Approval date: 05 Nov 2010

Within a hospital, infectious disease can potentially pass from person-to-person through close contact. Without comprehensive data on actual contacts between different patients (contact ‘networks’), it is reasonable to assume that there is an increased chance of transmission of an infection between ... READ MORE

Detecting and adjusting for severe illness in inpatients using passively collected data

COMPLETED
IORD category: Electronic Health Records
Chief Investigator: Dr David Wyllie · Sponsor: OUH · Research location: OUH NHS Trust · Approval date: 04 Mar 2010

See manuscript on The Lancet ... READ MORE

Improving threat detection and quality surveillance: tools for infection management

COMPLETED
IORD category: Electronic Health Records
Chief Investigator: Dr David Wyllie · Sponsor: OUH · Research location: OUH NHS Trust · Approval date: 04 Mar 2010

Summary of findings: We found that increases in severity of C. difficile diarrhoea, likely to due to the arrival of the hypervirulent 027 strain in the UK, could have been detected three years early using routine monitoring of neutrophil counts at diagnosis, compared with looking at patient ... READ MORE

Modernising Medical Microbiology and Big Infection Diagnostics

  • Modernising Medical Microbiology and Big Infection Diagnostics
  • Sub-theme 1: Novel rapid, high-throughput diagnostic workflows for infection
  • Sub-theme 2: Big data-led infection diagnosis and management strategies
  • Infections in Oxfordshire Research Database (IORD)
    • IORD Projects
  • Contacts
  • Videos
  • News

Subscribe to the Oxford BRC Newsletter

Keep informed about the work of the Oxford BRC by subscribing to our Mailchimp e-newsletter. It is produced several times a year and delivers news and information about upcoming events straight to your inbox.

Subscribe Now

Oxford BRC on Social Media

  • Facebook
  • LinkedIn
  • Twitter
  • YouTube

Feedback

We’d love to hear your feedback. Please contact us at obrcenquiries@ouh.nhs.uk

  • Data Control and Privacy
  • Accessibility
  • Our Partners
  • Disclaimer
  • Contact

Copyright © 2023 NIHR Oxford Biomedical Research Centre