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Research Theme

Modernising Medical Microbiology and Big Infection Diagnostics

Home > Research Themes Overview > Modernising Medical Microbiology and Big Infection Diagnostics > Infections in Oxfordshire Research Database > IORD Projects

IORD – Ongoing approved projects and project outputs

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Identifying “at-risk” populations for E. coli bacteraemias

ONGOING
IORD category: Specific Infections, Specific Pathogens
Chief Investigator: Prof Sarah Walker · Sponsor: OUH · Research location: Oxford University · Approval date: 14 Jan 2022

Since June 2011, every bloodstream infection caused by a bacteria called Escherichia coli (E. coli) has to be reported to the UK Health Security Agency. Monthly counts are published regularly, as well as annual reports describing the overall trend, distribution by age and sex, and geographic ... READ MORE

Analysis of 5 year trends in respiratory virus infections of haematology inpatients at Oxford University Hospitals

ONGOING
IORD category: Specific Infections, Specific Pathogens
Chief Investigator: Dr Toby Eyre · Sponsor: OUH · Research location: Oxford University · Approval date: 09 Apr 2021

Respiratory viral infections can cause serious illnesses in patients with weakened immune systems, such as those who have undergone a bone marrow transplant, or are undergoing chemotherapy for blood cancers. The Haematology department at Oxford University Hospitals (OUH) routinely tests for these ... READ MORE

An epidemiological review of paediatric respiratory viruses in acute hospital presentations with respiratory symptoms

COMPLETED
IORD category: Specific Infections, Specific Pathogens
Chief Investigator: Dr Nicholas Richens · Sponsor: OUH · Research location: Oxford University · Approval date: 09 Apr 2021

Respiratory viral pathogens have long been known to be responsible for a large burden of seasonal acute paediatric emergency department presentations. We are investigating the local epidemiology of these viral agents which prompt emergency department presentation. The SARS-CoV-2 pandemic has ... READ MORE

Impact of antibiotics on detection and transmission of MRSA

COMPLETED
IORD category: Antimicrobial Resistance and Antibiotics, Specific Pathogens
Chief Investigator: Dr David Eyre · Sponsor: OUH · Research location: Oxford University · Approval date: 02 Jul 2019

Antibiotics are commonly used to treat infections, but they may also affect how other infections are detected and transmitted. MRSA is a potentially serious healthcare-associated infection. Over the past decade there has been major progress in reducing the number of patients who carry MRSA on their ... READ MORE

PREDICTS’: Prognosis and Risk Evaluation, Determined from Influenza CT Scores

COMPLETED
IORD category: Specific Pathogens
Chief Investigator: Dr Philippa Matthews · Sponsor: OUH · Research location: Oxford University · Approval date: 12 Jun 2019

Every year, influenza virus causes significant illness globally. Many people are admitted to the John Radcliffe hospital with the virus and tested using molecular test. Currently, we do not use all the information that the test provides. This study aims to use the extra information from the current ... READ MORE

Investigating overlap between Enterobacteriaceae isolated from wastewater environments and patients

COMPLETED
IORD category: Specific Pathogens
Chief Investigator: Dr Bede Constantinides · Sponsor: OUH · Research location: Oxford University · Approval date: 29 Mar 2019

There are increasing numbers of reports of micro-organisms that can cause human infections being found in wastewater environments, like sinks, drains and toilets. These could potentially be transmitted to unwell people in hospitals. However, whether this really occurs is unclear. We have sequenced ... READ MORE

Investigating transmission of influenza in the Oxford University Hospitals

COMPLETED
IORD category: Specific Pathogens
Chief Investigator: Dr Philippa Matthews · Sponsor: OUH · Research location: Oxford University · Approval date: 29 Mar 2019

Every year influenza (‘flu’) puts a major strain on UK hospitals. Whilst many patients are admitted with influenza, other patients can get it during their hospital stay. This is because it is very easy to transmit, and it is not always obvious who has flu. We are using genetic sequencing to work out ... READ MORE

What is driving changes in the incidence of E. coli bloodstream infections in Oxfordshire?

COMPLETED
IORD category: Specific Pathogens
Chief Investigator: Prof Sarah Walker · Sponsor: OUH · Research location: Oxford University · Approval date: 07 Nov 2018

Across England, the number of bloodstream infections caused by a group of bacteria which include ‘Esherichia coli’ (E. coli) and ‘Klebsiella pneuomoniae’ (K. pneumoniae) has been rising significantly for the last few years. A recent investigation by our group using the IORD database has in addition ... READ MORE

What is driving changes in the incidence of Streptococcal infections in Oxfordshire?

COMPLETED
IORD category: Specific Pathogens
Chief Investigator: Phuong Quan · Sponsor: OUH · Research location: Oxford University · Approval date: 12 Oct 2017

Across England, the number of infections caused by a family of bacteria called Streptococcus have been rising strongly for the last few years. However, the reasons behind these increases are not well understood at the moment. We plan to use the extra information in the IORD database to look at ... READ MORE

Impact on gram-negative bacteraemia of empirically prescribed antibiotics

ONGOING
IORD category: Specific Pathogens
Chief Investigator: Prof Sarah Walker · Sponsor: OUH · Research location: Oxford University · Approval date: 12 Oct 2017

Antibiotics are prescribed when sick patients arrive at hospital, before doctors know what kind of bacteria is causing an infection and what antibiotics it might be resistant to. Even when a bacteria is identified as causing an infection, it is labelled as “resistant” (R) or “susceptible” (S) based ... READ MORE

Investigation into novel outbreak with Candida auris

COMPLETED
IORD category: Specific Pathogens
Chief Investigator: Dr Katie Jeffrey · Sponsor: OUH · Research location: OUH NHS Trust · Approval date: 16 Jun 2017

Recently a fungus called Candida auris, resistant to multiple antifungal treatments, emerged globally. It is related to the family that causes thrush, Candida albicans, but behaves differently, usually infecting or colonizing patients in intensive care facilities. This organism is now colonizing ... READ MORE

What is driving changes in the incidence of E. coli bloodstream infections in Oxfordshire?

COMPLETED
IORD category: Specific Pathogens
Chief Investigator: Prof Sarah Walker · Sponsor: OUH · Research location: OUH NHS Trust · Approval date: 21 Jul 2016

Across England, the number of bloodstream infections caused by a bacteria called ‘Esherichia coli’ (E. coli) have been rising strongly for the last few years. However, the reasons behind these increases are not well understood at the moment. We plan to use the extra information in the IORD database ... READ MORE

Trends in bacterial pathogens, antibiotic resistance, antibiotic usage and patient outcomes in critical care in the Oxford University NHS Trust hospitals, 1999-2014

COMPLETED
IORD category: Antimicrobial Resistance and Antibiotics, Electronic Health Records, Specific Pathogens
Chief Investigator: Dr Nicole Stoesser · Sponsor: OUH · Research location: Oxford University · Approval date: 12 Jan 2015

Antibiotics are medicines that are hugely important in treating many infections, and antibiotic resistance is a major clinical problem. Research has shown that increased use of antibiotics, whether appropriate or inappropriate, seems to be associated with higher numbers of antibiotic-resistant ... READ MORE

Determining patterns of Gram Negative resistance and their genetic basis

COMPLETED
IORD category: Specific Pathogens
Chief Investigator: Dr David Clifton · Sponsor: OUH · Research location: Oxford University · Approval date: 17 Sep 2014

Our knowledge of resistance of bacteria, such as E. coli, to antibiotic drugs is incomplete. An understanding of how such resistance is passed on from generation to generation of bacteria is important in helping us to determine which drugs should be given to patients, and in helping us formulate new ... READ MORE

Incidence and outcomes following C. difficile infections in Oxfordshire, and predictors of poor outcomes

COMPLETED
IORD category: Specific Pathogens
Chief Investigator: Dr Sarah Walker · Sponsor: OUH · Research location: OUH NHS Trust · Approval date: 14 Sep 2012

This project aims to estimate the incidence of C. difficile infection in Oxfordshire, inside and outside hospitals (inpatient, outpatient/day case/A&E, community), over calendar time, analysing the trends to identify potential new strains (as measured by multi-locus sequence type, MLST) ... READ MORE

C. difficile recurrence: incidence, predictors and risk scores

COMPLETED
IORD category: Specific Pathogens
Chief Investigator: Dr Sarah Walker · Sponsor: OUH · Research location: OUH NHS Trust · Approval date: 14 Sep 2012

This project focusses on patients who do not recover straightaway from C. difficile, but in whom either initial treatment for the infection does not work, or in whom the infection comes back (termed “recurrence” of infection). We want to work how often C. difficile recurrence happens, and how long ... READ MORE

C. difficile transmission in Oxfordshire hospitals 2006-2009 using Markov Chain Monte Carlo estimation and information from patients not tested for C. difficile

COMPLETED
IORD category: Specific Pathogens
Chief Investigator: Dr Madeleine Cule · Sponsor: OUH · Research location: OU Dept of Statistics · Approval date: 05 Nov 2010

See publication: Probabilistic transmission models incorporating sequencing data for healthcare-associated Clostridioides difficile outperform heuristic rules and identify strain-specific differences in transmission ... READ MORE

S. aureus transmission in ITU, Trauma, Geratology and Vascular specialities in the John Radcliffe Hospital, Oxford 2009-

COMPLETED
IORD category: Specific Pathogens
Chief Investigator: Prof Derrick Crook · Sponsor: OUH · Research location: OUH NHS Trust, OU Dept of Statistics, WTCHG · Approval date: 05 Nov 2010

... READ MORE

Analysis of 2009/10 Hospital Norovirus outbreak

COMPLETED
IORD category: Specific Pathogens
Chief Investigator: Dr Nick Wong · Sponsor: OUH · Research location: OUH NHS Trust · Approval date: 05 Nov 2010

... READ MORE

Mortality following invasive pneumococcal disease in Oxfordshire 1995-2010

COMPLETED
IORD category: Specific Pathogens
Chief Investigator: Dr Kyle Knox · Sponsor: OUH · Research location: OUH NHS Trust · Approval date: 05 Nov 2010

... READ MORE

C. difficile testing specificity in Oxfordshire 1997-2009

COMPLETED
IORD category: Specific Pathogens
Chief Investigator: · Sponsor: OUH · Research location: OUH NHS Trust · Approval date: 04 Mar 2010

... READ MORE

C. difficile transmission in Oxfordshire hospitals 2006-2009

COMPLETED
IORD category: Specific Pathogens
Chief Investigator: Prof Tim Peto · Sponsor: OUH · Research location: OUH NHS Trust · Approval date: 04 Mar 2010

Summary of findings: In an endemic setting, with well-implemented infection control measures, ward-based contact with other patients with C. difficile diarrhoea cannot account for the majority of new cases – no more than 25% of new cases in Oxfordshire over 2 years could be linked to a previous ... READ MORE

Incidence of and competition between different pathogens isolated from blood and other sterile sites in Oxfordshire 1997-2009

COMPLETED
IORD category: Specific Pathogens
Chief Investigator: Dr David Wyllie · Sponsor: OUH · Research location: OUH NHS Trust · Approval date: 04 Mar 2010

... READ MORE

Competition between MRSA and MSSA at an individual level in Oxfordshire 1997-2009

COMPLETED
IORD category: Specific Pathogens
Chief Investigator: Dr A. Sarah Walker · Sponsor: OUH · Research location: OUH NHS Trust · Approval date: 04 Mar 2010

... READ MORE

MRSA incidence 1998-2009

COMPLETED
IORD category: Specific Pathogens
Chief Investigator: Dr David Wyllie · Sponsor: OUH · Research location: OUH NHS Trust · Approval date: 04 Mar 2010

Summary of findings: Rates of MRSA infection in blood and other sites were falling before intensification of infection-control measures in 2006. This, together with strain-specific changes in MRSA isolation, strongly suggests that incompletely understood biological factors are responsible for the ... READ MORE

Klebsiella in Oxfordshire 1998-2009

COMPLETED
IORD category: Specific Pathogens
Chief Investigator: Dr A. Sarah Walker · Sponsor: OUH · Research location: OUH NHS Trust · Approval date: 04 Mar 2010

... READ MORE

Nosocomial MRSA endemicity: addition or replacement (multi-centre, multi-cohort study)

COMPLETED
IORD category: Specific Pathogens
Chief Investigator: Prof Marc Bonten · Sponsor: Utrecht University · Research location: University Med Centre Utrecht · Approval date: 04 Mar 2010

Summary of findings: Trends in the rates of serious bloodstream infections caused by antibiotic-sensitive microbes were similar between 1998-2007 across 14 hospitals in Europe, but rates of serious bloodstream infections caused by antibiotic-resistant microbes increased much more in hospitals in ... READ MORE

Modernising Medical Microbiology and Big Infection Diagnostics

  • Modernising Medical Microbiology and Big Infection Diagnostics
  • Sub-theme 1: Novel rapid, high-throughput diagnostic workflows for infection
  • Sub-theme 2: Big data-led infection diagnosis and management strategies
  • Infections in Oxfordshire Research Database (IORD)
    • IORD Projects
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