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Research Theme

Antimicrobial Resistance and Modernising Microbiology

Home > Research Themes > Antimicrobial Resistance and Modernising Microbiology > IORD Projects

IORD – Ongoing approved projects and project outputs

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Global Research on AntiMicrobial resistance (GRAM) Project

IORD categorisation: Antimicrobial Resistance and Antibiotics, Specific Infections

The Global Research on AntiMicrobial resistance (GRAM) Project is the flagship study of the Oxford GBD (Global Burden of Disease) Group, and aims to provide robust, comprehensive and timely evidence of the burden of antimicrobial resistance (AMR) in 195 countries and territories. The Oxford GBD Group is a partnership between the Big Data Institute (BDI) … Read more

The impact of SARS-CoV-2 on hospital admissions, antimicrobial prescribing and serious bacterial infections

IORD categorisation: Antimicrobial Resistance and Antibiotics, COVID-19

The Covid-19 pandemic is having a profound impact on healthcare globally. Whilst the virus is directly devastating for many suffering from severe infection, there are also wider implications. These include potentially lower use of healthcare for other serious conditions with potential adverse outcomes. Additionally, managing Covid-19 cases may change antibiotic prescribing in hospitals, and have … Read more

Impact of antibiotics on detection and transmission of MRSA

IORD categorisation: Antimicrobial Resistance and Antibiotics, Specific Pathogens

Antibiotics are commonly used to treat infections, but they may also affect how other infections are detected and transmitted. MRSA is a potentially serious healthcare-associated infection. Over the past decade there has been major progress in reducing the number of patients who carry MRSA on their skin and other body sites, and in reducing infections … Read more

Can we estimate resistance in bloodstream infections from resistance in other types of specimen?

IORD categorisation: Antimicrobial Resistance and Antibiotics, Specific Infections

In order to reduce the threat of antimicrobial resistance, a first key step is to understand how much resistance there is. This is typically done by looking at bacteria causing serious infections, particularly bloodstream infections. However, growing bacteria from blood usually requires sophisticated machines which heat samples of blood in special nutrients. These machines are … Read more

Antimicrobial prescribing and risk of future resistant infection

IORD categorisation: Antimicrobial Resistance and Antibiotics

Infections due to one particular family of bacteria called Enterobacteriaceae are increasing in Oxfordshire and worldwide, as are infections resistant to the commonly-used beta-lactam antibiotics (such as co-amoxiclav, sometimes also called augmentin). Treating people with particular types of antibiotics may make people more likely to get resistant infections in the future. We want to see … Read more

Antibiotic use – if you use less antibiotic in general medicine are there adverse consequences?

IORD categorisation: Antimicrobial Resistance and Antibiotics

Reducing antibiotic use to combat antimicrobial resistance is a priority. We want to know if we can do this safely and without putting patients at undue risk. Antibiotic use was measured over 1 week in an intensive audit of practice in the Acute/General Medicine service at the John Radcliffe. This showed that one Consultant team … Read more

Trends in bacterial pathogens, antibiotic resistance, antibiotic usage and patient outcomes in critical care in the Oxford University NHS Trust hospitals, 1999-2014

IORD categorisation: Antimicrobial Resistance and Antibiotics, Electronic Health Records, Specific Pathogens

Antibiotics are medicines that are hugely important in treating many infections, and antibiotic resistance is a major clinical problem. Research has shown that increased use of antibiotics, whether appropriate or inappropriate, seems to be associated with higher numbers of antibiotic-resistant infections. To develop the best treatment strategies, it is important to understand which bacteria (bugs) … Read more

Antimicrobial susceptibility profiles of urinary isolates from samples collected in the community

IORD categorisation: Antimicrobial Resistance and Antibiotics

Urinary tract infections comprise around 1% of the 300 million general practice consultations annually in the UK; most of these are acute uncomplicated UTIs (AUUTIs) in women of childbearing age. AUUTIs affect around 50% of women during their lifetime and, by 24 years of age, one-third of women have had a UTI. Although AUUTIs generally … Read more

Antimicrobial Resistance and Modernising Microbiology Theme

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