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Research Theme

Antimicrobial Resistance and Modernising Microbiology

Home > Research Themes > Antimicrobial Resistance and Modernising Microbiology > IORD Projects

IORD – Ongoing approved projects and project outputs

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A clinical data review to support investigation of a European outbreak of acute severe hepatitis of unknown etiology (ASHep-UE)

IORD categorisation: COVID-19, Specific Infections

Since 31 March 2022, there has been an increase in cases of children presenting with severe liver disease of unknown cause (termed ‘acute severe hepatitis of unknown etiology’ (ASHep-UE)) across multiple countries including the UK. Most of these have been children aged 1–6 years, leading to hospital admissions requiring intensive care, and in some cases … Read more

Analysis of trends in mortality rates following infection with SARS-CoV-2 in patients with underlying haemato-oncology diagnoses at Oxford University Hospitals

IORD categorisation: COVID-19

Underlying haematological malignancy has previously been shown to be a major risk factor for worse outcomes from infection with SARS-CoV-2. There is concern that this same patient group may mount reduced immune responses to the COVID-19 vaccinations, and thus derive less protection from them. In the general population, with high levels of vaccination, serious adverse … Read more

PREPARE 2 – The impact of the COVID-19 pandemic on infections in myeloma patients

IORD categorisation: COVID-19

Myeloma is a blood cancer that results in a weakened immune system and an increased risk of infection. Myeloma is currently incurable and the most common cause of death in patients living with myeloma, aside from the disease itself, is infection. We know that rates of respiratory infections decreased in haematology patients during shielding due … Read more

The prognostic utility of the MeMed COVID-19 Severity™ assay in patients with COVID-19 at Oxford University Hospitals NHS Foundation Trust (OUH)

IORD categorisation: COVID-19

COVID-19 caused by SARS-CoV2, remains a significant cause of hospital attendance, admission and mortality. The clinical presentation of COVID-19 is variable, with most patients experiencing mild self-limiting symptoms, while others progress to respiratory failure. The use of biomarkers early in the disease course, to predict the development of severe disease, has garnered significant interest as … Read more

Circadian influences on serologic responses to SARS-CoV-2 vaccination

IORD categorisation: COVID-19

The ‘circadian clock’ is an endogenous 24-hour clock recognised in all biology that, along with a seasonal clock (summer/winter), impacts on how environmental challenges are handled, including the outcome of infectious diseases and vaccinations. The COVID-19 pandemic, caused by SARS-CoV-2 coronavirus, is a global crisis with unprecedented challenges for public health. Vaccinations are being rolled … Read more

Using Machine Learning to Predict Mortality for COVID-19 Patients on Day Zero in the ICU

IORD categorisation: COVID-19

Using a dataset of 270 critically ill patients with COVID-19 we have identified a set of variables that predict the mortality for patients on the day of admission to the ICU. The use of this practical prediction model should affect clinical decision-making and medical management of COVID-19 patients. We can predict the chance of survival … Read more

Assessing the utility of calprotectin as an independent predictor of clinical deterioration following COVID diagnoses

IORD categorisation: COVID-19

COVID-19, caused by SARS-CoV2, is a novel biphasic disease that may be associated with significant morbidity and mortality in the second phase of illness in select groups of infected individuals. There is significant interest in testing the utility of biomarkers in the first phase of illness for identifying individuals at higher risk of deterioration who … Read more

THE COVID CLOCK: Circadian influences on SARS-CoV-2 RNA in nose and throat swabs

IORD categorisation: COVID-19

The ‘circadian clock’ is an inbuilt 24-hour clock recognised in human biology that, along with a seasonal clock (summer/winter), impacts on how environmental challenges are handled, including influencing the outcome of infectious diseases and vaccinations (Borrmann 2020, Sengupta 2021).The COVID-19 pandemic, caused by SARS-CoV-2 coronavirus, is a global crisis with unprecedented challenges for public health. … Read more

Healthcare associated acquisition of Covid-19

IORD categorisation: COVID-19

Most patients diagnosed with Covid-19 acquire their infection in the community. However, it is not known how much Covid-19 in the first wave of the pandemic was acquired in hospital. National data may be informative, but locally available data in Oxford are more detailed, potentially allowing more precise estimates of the extent of transmission and … Read more

Covid-19 seroprevalence in inflammatory bowel disease patients on maintenance biological therapy: a comparison with healthcare workers

IORD categorisation: COVID-19

The inflammatory bowel diseases (IBD), Crohn’s disease (CD) and ulcerative colitis (UC) affect approximately 1% of the UK population; and 25-30% of these patients are now treated with biological therapies which target the immune system to maintain remission. It has been hypothesized that these patients may be at increased risk of either clinically apparent SARS-CoV-2 … Read more

Descriptive Study of confirmed and probable COVID patients

IORD categorisation: COVID-19

The COVID-19 pandemic started in December 2019 and quickly spread around the world. A key challenge in all healthcare settings is to identify patients with possible COVID-19 at presentation, to inform both clinical management and infection prevention and control interventions. Diagnosis relies in most cases on PCR of nose and throat swabs for the SARS-CoV-2 … Read more

Aggregate analysis of Oxford University Hospitals staff Covid-19 testing data

IORD categorisation: COVID-19

Oxford University Hospitals (OUH) has conducted a large staff testing programme for Covid-19. Staff were tested using a combination of antibody and PCR tests looking for previous and current infection with the virus that causes Covid-19 (SARS-CoV-2). These results were stored in the electronic healthcare records of each staff member. Staff provided details of potential … Read more

PreVent: predicting need to ventilation and ICU admission in patients admitted with COVID-19

IORD categorisation: COVID-19

Up to 30% of patients admitted to hospital with COVID (novel coronavirus infection) will require admission to an intensive care unit (ICU) and potentially help with breathing via a ventilator. We will develop statistical and artificial intelligence approaches to predict which patients are most likely to require admission to ICU and ventilation. These tools will … Read more

The impact of SARS-CoV-2 on hospital admissions, antimicrobial prescribing and serious bacterial infections

IORD categorisation: Antimicrobial Resistance and Antibiotics, COVID-19

The Covid-19 pandemic is having a profound impact on healthcare globally. Whilst the virus is directly devastating for many suffering from severe infection, there are also wider implications. These include potentially lower use of healthcare for other serious conditions with potential adverse outcomes. Additionally, managing Covid-19 cases may change antibiotic prescribing in hospitals, and have … Read more

Antimicrobial Resistance and Modernising Microbiology Theme

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  • Infections in Oxfordshire Research Database (IORD)
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