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Research Theme

Modernising Medical Microbiology and Big Infection Diagnostics

Home > Research Themes Overview > Modernising Medical Microbiology and Big Infection Diagnostics > Infections in Oxfordshire Research Database > IORD Projects

IORD – Ongoing approved projects and project outputs

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A clinical data review to support investigation of a European outbreak of acute severe hepatitis of unknown etiology (ASHep-UE)

ONGOING
IORD category: COVID-19, Specific Infections
Chief Investigator: Dr Philippa Matthews · Sponsor: OUH · Research location: OUH NHS Trust · Approval date: 13 May 2022

Since 31 March 2022, there has been an increase in cases of children presenting with severe liver disease of unknown cause (termed ‘acute severe hepatitis of unknown etiology’ (ASHep-UE)) across multiple countries including the UK. Most of these have been children aged 1–6 years, leading to hospital ... READ MORE

Analysis of trends in mortality rates following infection with SARS-CoV-2 in patients with underlying haemato-oncology diagnoses at Oxford University Hospitals

ONGOING
IORD category: COVID-19
Chief Investigator: Dr John Willan · Sponsor: OUH · Research location: OUH NHS Trust · Approval date: 09 May 2022

Underlying haematological malignancy has previously been shown to be a major risk factor for worse outcomes from infection with SARS-CoV-2. There is concern that this same patient group may mount reduced immune responses to the COVID-19 vaccinations, and thus derive less protection from them. In ... READ MORE

PREPARE 2 – The impact of the COVID-19 pandemic on infections in myeloma patients

ONGOING
IORD category: COVID-19
Chief Investigator: Dr Sally Moore · Sponsor: OUH · Research location: OUH NHS Trust · Approval date: 21 Feb 2022

Myeloma is a blood cancer that results in a weakened immune system and an increased risk of infection. Myeloma is currently incurable and the most common cause of death in patients living with myeloma, aside from the disease itself, is infection. We know that rates of respiratory infections ... READ MORE

The prognostic utility of the MeMed COVID-19 Severity™ assay in patients with COVID-19 at Oxford University Hospitals NHS Foundation Trust (OUH)

ONGOING
IORD category: COVID-19
Chief Investigator: Dr Alexander Mentzer, Dr James Fullerton · Sponsor: OUH · Research location: Oxford University · Approval date: 24 Jan 2022

COVID-19 caused by SARS-CoV2, remains a significant cause of hospital attendance, admission and mortality. The clinical presentation of COVID-19 is variable, with most patients experiencing mild self-limiting symptoms, while others progress to respiratory failure. The use of biomarkers early in the ... READ MORE

Circadian influences on serologic responses to SARS-CoV-2 vaccination

ONGOING
IORD category: COVID-19
Chief Investigator: Prof Jane McKeating · Sponsor: OUH · Research location: OUH NHS Trust · Approval date: 12 Jul 2021

The ‘circadian clock’ is an endogenous 24-hour clock recognised in all biology that, along with a seasonal clock (summer/winter), impacts on how environmental challenges are handled, including the outcome of infectious diseases and vaccinations. The COVID-19 pandemic, caused by SARS-CoV-2 ... READ MORE

Using Machine Learning to Predict Mortality for COVID-19 Patients on Day Zero in the ICU

ONGOING
IORD category: COVID-19
Chief Investigator: Dr Nahal Mansouri · Sponsor: Lausanne University Hospital · Research location: Lausanne University Hospital · Approval date: 28 May 2021

Using a dataset of 270 critically ill patients with COVID-19 we have identified a set of variables that predict the mortality for patients on the day of admission to the ICU. The use of this practical prediction model should affect clinical decision-making and medical management of COVID-19 ... READ MORE

Assessing the utility of calprotectin as an independent predictor of clinical deterioration following COVID diagnoses

COMPLETED
IORD category: COVID-19
Chief Investigator: Dr Alexander Mentzer · Sponsor: OUH · Research location: Oxford University · Approval date: 09 Apr 2021

COVID-19, caused by SARS-CoV2, is a novel biphasic disease that may be associated with significant morbidity and mortality in the second phase of illness in select groups of infected individuals. There is significant interest in testing the utility of biomarkers in the first phase of illness for ... READ MORE

THE COVID CLOCK: Circadian influences on SARS-CoV-2 RNA in nose and throat swabs

ONGOING
IORD category: COVID-19
Chief Investigator: Professor Jane McKeating · Sponsor: NIHR OxBRC · Research location: OUH NHS Trust · Approval date: 22 Mar 2021

The ‘circadian clock’ is an inbuilt 24-hour clock recognised in human biology that, along with a seasonal clock (summer/winter), impacts on how environmental challenges are handled, including influencing the outcome of infectious diseases and vaccinations (Borrmann 2020, Sengupta 2021).The COVID-19 ... READ MORE

Healthcare associated acquisition of Covid-19

ONGOING
IORD category: COVID-19
Chief Investigator: Dr David Eyre · Sponsor: OUH · Research location: Oxford University · Approval date: 18 Oct 2020

Most patients diagnosed with Covid-19 acquire their infection in the community. However, it is not known how much Covid-19 in the first wave of the pandemic was acquired in hospital. National data may be informative, but locally available data in Oxford are more detailed, potentially allowing ... READ MORE

Covid-19 seroprevalence in inflammatory bowel disease patients on maintenance biological therapy: a comparison with healthcare workers

ONGOING
IORD category: COVID-19
Chief Investigator: Professor Jack Satsangi · Sponsor: OUH · Research location: Oxford University · Approval date: 18 Oct 2020

The inflammatory bowel diseases (IBD), Crohn’s disease (CD) and ulcerative colitis (UC) affect approximately 1% of the UK population; and 25-30% of these patients are now treated with biological therapies which target the immune system to maintain remission. It has been hypothesized that these ... READ MORE

Descriptive Study of confirmed and probable COVID patients

ONGOING
IORD category: COVID-19
Chief Investigator: Dr Andrew Brent, Dr Monique Andersson · Sponsor: OUH · Research location: Oxford University · Approval date: 07 Aug 2020

The COVID-19 pandemic started in December 2019 and quickly spread around the world. A key challenge in all healthcare settings is to identify patients with possible COVID-19 at presentation, to inform both clinical management and infection prevention and control interventions. Diagnosis relies in ... READ MORE

Aggregate analysis of Oxford University Hospitals staff Covid-19 testing data

COMPLETED
IORD category: COVID-19
Chief Investigator: Dr David Eyre · Sponsor: OUH · Research location: Oxford University · Approval date: 24 Jun 2020

Oxford University Hospitals (OUH) has conducted a large staff testing programme for Covid-19. Staff were tested using a combination of antibody and PCR tests looking for previous and current infection with the virus that causes Covid-19 (SARS-CoV-2). These results were stored in the electronic ... READ MORE

PreVent: predicting need to ventilation and ICU admission in patients admitted with COVID-19

COMPLETED
IORD category: COVID-19
Chief Investigator: Dr David Eyre · Sponsor: OUH · Research location: Oxford University · Approval date: 05 May 2020

Up to 30% of patients admitted to hospital with COVID (novel coronavirus infection) will require admission to an intensive care unit (ICU) and potentially help with breathing via a ventilator. We will develop statistical and artificial intelligence approaches to predict which patients are most ... READ MORE

The impact of SARS-CoV-2 on hospital admissions, antimicrobial prescribing and serious bacterial infections

COMPLETED
IORD category: Antimicrobial Resistance and Antibiotics, COVID-19
Chief Investigator: Prof Sarah Walker · Sponsor: OUH · Research location: Oxford University · Approval date: 05 May 2020

The Covid-19 pandemic is having a profound impact on healthcare globally. Whilst the virus is directly devastating for many suffering from severe infection, there are also wider implications. These include potentially lower use of healthcare for other serious conditions with potential adverse ... READ MORE

Modernising Medical Microbiology and Big Infection Diagnostics

  • Modernising Medical Microbiology and Big Infection Diagnostics
  • Sub-theme 1: Novel rapid, high-throughput diagnostic workflows for infection
  • Sub-theme 2: Big data-led infection diagnosis and management strategies
  • Infections in Oxfordshire Research Database (IORD)
    • IORD Projects
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