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Research Theme

Modernising Medical Microbiology and Big Infection Diagnostics

Home > Research Themes Overview > Modernising Medical Microbiology and Big Infection Diagnostics > Infections in Oxfordshire Research Database > IORD Projects > Analysis of trends in mortality rates following infection with SARS-CoV-2 in patients with underlying haemato-oncology diagnoses at Oxford University Hospitals

IORD Project

Analysis of trends in mortality rates following infection with SARS-CoV-2 in patients with underlying haemato-oncology diagnoses at Oxford University Hospitals

ONGOING
IORD category: COVID-19
Chief Investigator: Dr John Willan
Sponsor: OUH
Research location: OUH NHS Trust
Approval date: 09 May 2022

Underlying haematological malignancy has previously been shown to be a major risk factor for worse outcomes from infection with SARS-CoV-2. There is concern that this same patient group may mount reduced immune responses to the COVID-19 vaccinations, and thus derive less protection from them.

In the general population, with high levels of vaccination, serious adverse outcomes from SARS-CoV-2 infection in patients with the Omicron variant appear to be much reduced, but it is not yet clear what level of risk remains in patients with underlying haematological malignancies.

We propose to analyse rates of death in this group of patients since the start of the pandemic, to determine if there is a trend to reducing death rates, and to help us counsel our patient population on the residual degree of risk remaining from infection.

Depending on the number of cases, we hope to assess the impact of age, underlying haematological diagnosis and comorbidities on the mortality rates.

Modernising Medical Microbiology and Big Infection Diagnostics

  • Modernising Medical Microbiology and Big Infection Diagnostics
  • Sub-theme 1: Novel rapid, high-throughput diagnostic workflows for infection
  • Sub-theme 2: Big data-led infection diagnosis and management strategies
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