NIHR Oxford Biomedical Research Centre

Enabling translational research through partnership

MENUMENU
  • About
    • About the NIHR Oxford Biomedical Research Centre
    • A Guide to What We Do
    • Activities during COVID-19
    • Strategic Partnership Board
    • Steering Committee
    • Promoting Equality, Diversity and Inclusion in Research
    • Current Vacancies
    • Contact Us
    • Stay in Touch
  • Research
        • OUR 20 RESEARCH THEMES

        • Antimicrobial Resistance and Modernising Microbiology
        • Cardiovascular
        • Clinical Informatics and Big Data
        • Diabetes and Metabolism
        • Gastroenterology and Mucosal Immunity
        • Genomic Medicine
        • Haematology and Stem Cells
        • Imaging
        • Molecular Diagnostics
        • Multi-Modal Cancer Therapies
        • Multi-Morbidity and Long-Term Conditions
        • Musculoskeletal
        • Neurological Conditions
        • Obesity, Diet and Lifestyle
        • Partnerships for Health, Wealth and Innovation
        • Respiratory
        • Stroke and Vascular Dementia
        • Surgical Innovation and Evaluation
        • Technology and Digital Health
        • Vaccines for Emerging and Endemic Diseases
        • Oxford Biomedical Research Centre activities during COVID-19
  • Patient & Public Involvement
    • Getting involved with research
    • Researcher Guidance
    • Post an opportunity for patient and public involvement
  • Training Hub
    • Training Hub Overview
    • Clinical Academic Pathway
    • Internships
    • Preparatory Research Fellowships
    • Senior Research Fellowships
    • Research Training Bursaries
    • Doctoral Awards
    • Post-Doctoral Awards
    • Other funding
    • Leadership Training
    • Useful Links
    • Training and Education Resources
    • Upcoming Training Events & Courses
  • Industry
    • Collaborate with Oxford BRC
    • What Can We Do For Your Organisation?
    • Who Do We Work With?
    • IP and Licensing
    • Contacts for Industry
  • Videos
  • News
  • Events

Antimicrobial Resistance and Modernising Microbiology

Home > Research Themes > Antimicrobial Resistance and Modernising Microbiology > IORD Projects > Assessing the utility of calprotectin as an independent predictor of clinical deterioration following COVID diagnoses

Assessing the utility of calprotectin as an independent predictor of clinical deterioration following COVID diagnoses

IORD category: COVID-19
Chief Investigator: Dr Alexander Mentzer
Sponsor: OUH
Research location: Oxford University
Approval date: 09 Apr 2021

COVID-19, caused by SARS-CoV2, is a novel biphasic disease that may be associated with significant morbidity and mortality in the second phase of illness in select groups of infected individuals. There is significant interest in testing the utility of biomarkers in the first phase of illness for identifying individuals at higher risk of deterioration who may benefit from closer home or hospital monitoring. Calprotectin is an example of such a blood plasma biomarker that is widely hailed as a potentially independent predictor of deterioration. We have been measuring calprotectin in individuals presenting with suspected COVID-19 disease within 48 hours of presentation during the 2020-21 winter surge in a real-time manner using an assay set up in biochemistry. The results are stored on the biochemistry LIMS system and clinicians are blinded to the results given their uncertain clinical utility. Here we propose to link clinical data to these measures and test whether calprotectin levels within 48 hours of early assessment are a predictor of deterioration (as measured by a composite measure of need for non-invasive ventilation or admission onto intensive care or death) independent of current clinical or biochemical predictors.

Antimicrobial Resistance and Modernising Microbiology

  • Introduction
  • Infections in Oxfordshire Research Database (IORD)
  • IORD – Ongoing approved projects and project outputs
  • Contacts
  • Videos for this theme
  • News for this theme

Subscribe to the Oxford BRC Newsletter

Keep informed about the work of the Oxford BRC by subscribing to our Mailchimp e-newsletter. It is produced several times a year and delivers news and information about upcoming events straight to your inbox.

Subscribe Now

Oxford BRC on Social Media

  • Facebook
  • LinkedIn
  • Twitter
  • YouTube

Feedback

We’d love to hear your feedback. Please contact us at obrcenquiries@ouh.nhs.uk

  • Sitemap
  • Data Control and Privacy
  • Accessibility
  • Our Partners
  • Disclaimer
  • Contact

Copyright © 2022 NIHR Oxford Biomedical Research Centre