NIHR Oxford Biomedical Research Centre

Enabling translational research through partnership

MENUMENU
  • About
    • About the NIHR Oxford Biomedical Research Centre
    • NIHR Oxford BRC impact
    • Steering Committee
    • Promoting equality, diversity and inclusion in research
    • Current Vacancies
    • Stay in Touch
    • Contact Us
  • Research

        • Research Overview
        • Clinical Research Facility
        • Health Economics
        • Ethics in the NIHR Oxford BRC
        • Medical Statistics
        • Infections in Oxfordshire Database (IORD)
        • 15 Research Themes

        • Cancer
        • Cardiovascular Medicine
        • Digital Health from Hospital to Home
        • Gene and Cell Therapy
        • Genomic Medicine
        • Imaging
        • Inflammation across Tissues
        • Life-saving Vaccines
        • Metabolic Experimental Medicine
        • Modernising Medical Microbiology and Big Infection Diagnostics
        • Musculoskeletal
        • Preventive Neurology
        • Respiratory Medicine
        • Surgical Innovation, Technology and Evaluation
        • Translational Data Science
  • Patient and Public Involvement
    • For patients and the public
    • For researchers
    • More information
  • Training Hub
    • Training Hub Overview
    • Clinical Academic Pathway
    • Internships
    • Pre-doctoral Research Fellowships
    • Senior Research Fellowships
    • Research Training Bursaries
    • Doctoral Awards
    • Post-Doctoral Awards
    • PARC Programme
    • Other funding
    • Leadership Training
    • Useful Links
    • Training and Education Resources
    • Upcoming Training Events & Courses
  • Industry
    • Collaborate with Oxford BRC
    • Who Do We Work With?
    • Events
    • Further Information and Additional Resources
    • Contacts for Industry
  • Videos
  • News
  • Events
Research Theme

Modernising Medical Microbiology and Big Infection Diagnostics

Infections in Oxfordshire Database (IORD)
Home > Research Themes Overview > Modernising Medical Microbiology and Big Infection Diagnostics > Infections in Oxfordshire Research Database > IORD Projects > Circadian influences on serologic responses to SARS-CoV-2 vaccination

IORD Project

Circadian influences on serologic responses to SARS-CoV-2 vaccination

COMPLETED
IORD category: COVID-19
Chief Investigator: Prof Jane McKeating
Sponsor: OUH
Research location: OUH NHS Trust
Approval date: 12 Jul 2021

The ‘circadian clock’ is an endogenous 24-hour clock recognised in all biology that, along with a seasonal clock (summer/winter), impacts on how environmental challenges are handled, including the outcome of infectious diseases and vaccinations.

The COVID-19 pandemic, caused by SARS-CoV-2 coronavirus, is a global crisis with unprecedented challenges for public health. Vaccinations are being rolled out to slow the incidence of new infections and reduce disease severity. Circadian rhythms along with sleep quality have been proposed to influence vaccine-mediated immunity to a range of pathogens. It is noteworthy that morning vaccination against the respiratory pathogen influenza A virus in the elderly was associated with significantly higher levels of anti-viral antibodies. Based on the published literature we anticipate that immune responses to SARS-CoV-2 vaccines will show a diurnal pattern.

We will evaluate associations between the time-of-day of SARS-CoV-2 vaccination and sample collection with the magnitude of anti-Spike antibody titres in a cohort of health care workers who received either Pfizer or AstraZeneca vaccines.

See publication: Time-of-day variation in SARS-CoV-2 RNA levels during the second wave of COVID-19 infection

MODERNISING MEDICAL MICROBIOLOGY AND BIG INFECTION DIAGNOSTICS →

Infections in Oxfordshire Database (IORD)

  • IORD Overview
    • What data is in IORD?
    • Different kinds of data in IORD
    • Who can use the data?
    • How do they get the data?
    • What do they do with the data?
    • What kind of questions has IORD answered? Why is this important?
    • What was it like before IORD?
    • Opting out
  • IORD Application Trajectory
  • IORD Projects
  • IORD Publications
  • IORD Privacy Notice
  • IORD Glossary
  • IORD FAQs
  • IORD Infographics

Subscribe to the Oxford BRC Newsletter

Keep informed about the work of the Oxford BRC by subscribing to our Mailchimp e-newsletter. It is produced several times a year and delivers news and information about upcoming events straight to your inbox.

Subscribe Now

Feedback

We’d love to hear your feedback. Please contact us at [email protected]

Oxford BRC on Social Media

  • Bluesky
  • Facebook
  • LinkedIn
  • Threads
  • Twitter
  • YouTube
  • Data Control and Privacy
  • Accessibility
  • Our Partners
  • Disclaimer
  • Contact

Copyright © 2025 NIHR Oxford Biomedical Research Centre