NIHR Oxford Biomedical Research Centre

Enabling translational research through partnership

MENUMENU
  • About
    • About the NIHR Oxford Biomedical Research Centre
    • A Guide to What We Do
    • Activities during COVID-19
    • Strategic Partnership Board
    • Steering Committee
    • Promoting Equality, Diversity and Inclusion in Research
    • Current Vacancies
    • Contact Us
    • Stay in Touch
  • Research
        • OUR 20 RESEARCH THEMES

        • Antimicrobial Resistance and Modernising Microbiology
        • Cardiovascular
        • Clinical Informatics and Big Data
        • Diabetes and Metabolism
        • Gastroenterology and Mucosal Immunity
        • Genomic Medicine
        • Haematology and Stem Cells
        • Imaging
        • Molecular Diagnostics
        • Multi-Modal Cancer Therapies
        • Multi-Morbidity and Long-Term Conditions
        • Musculoskeletal
        • Neurological Conditions
        • Obesity, Diet and Lifestyle
        • Partnerships for Health, Wealth and Innovation
        • Respiratory
        • Stroke and Vascular Dementia
        • Surgical Innovation and Evaluation
        • Technology and Digital Health
        • Vaccines for Emerging and Endemic Diseases
        • Oxford Biomedical Research Centre activities during COVID-19
  • Patient & Public Involvement
    • Getting involved with research
    • Researcher Guidance
    • Post an opportunity for patient and public involvement
  • Training Hub
    • Training Hub Overview
    • Clinical Academic Pathway
    • Internships
    • Preparatory Research Fellowships
    • Senior Research Fellowships
    • Research Training Bursaries
    • Doctoral Awards
    • Post-Doctoral Awards
    • Other funding
    • Leadership Training
    • Useful Links
    • Training and Education Resources
    • Upcoming Training Events & Courses
  • Industry
    • Collaborate with Oxford BRC
    • What Can We Do For Your Organisation?
    • Who Do We Work With?
    • IP and Licensing
    • Contacts for Industry
  • Videos
  • News
  • Events

Antimicrobial Resistance and Modernising Microbiology

Home > Research Themes > Antimicrobial Resistance and Modernising Microbiology > IORD Projects > The prognostic utility of the MeMed COVID-19 Severity™ assay in patients with COVID-19 at Oxford University Hospitals NHS Foundation Trust (OUH)

The prognostic utility of the MeMed COVID-19 Severity™ assay in patients with COVID-19 at Oxford University Hospitals NHS Foundation Trust (OUH)

IORD category: COVID-19
Chief Investigator: Dr Alexander Mentzer, Dr James Fullerton
Sponsor: OUH
Research location: Oxford University
Approval date: 24 Jan 2022

COVID-19 caused by SARS-CoV2, remains a significant cause of hospital attendance, admission and mortality. The clinical presentation of COVID-19 is variable, with most patients experiencing mild self-limiting symptoms, while others progress to respiratory failure. The use of biomarkers early in the disease course, to predict the development of severe disease, has garnered significant interest as a guide to permit appropriate intervention and decision making regarding the setting of care. The MeMed COVID-19 Severity™ assay is a point of care assay based upon the host response. Quantifying and integrating serum concentrations of tumour necrosis factor-related apoptosis inducing-ligand (TRAIL), interferon gamma-induced protein 10 (IP-10) and C-reactive protein (CRP) via a proprietary algorithm, a numerical score from 0-100 (0 representing a low likelihood of severe outcome and 100 a high likelihood) is generated. We have set up a workflow to perform this assay in individuals presenting with PCR-confirmed COVID-19 disease. The results are stored on the biochemistry LIMS system, with clinicians blinded to the results. We propose to extract clinical data linked to these measures using the IORD structure and test whether admission MeMed COVID-19 Severity™ score is a predictor of deterioration independent of current clinical or biochemical predictors.

Antimicrobial Resistance and Modernising Microbiology

  • Introduction
  • Infections in Oxfordshire Research Database (IORD)
  • IORD – Ongoing approved projects and project outputs
  • Contacts
  • Videos for this theme
  • News for this theme

Subscribe to the Oxford BRC Newsletter

Keep informed about the work of the Oxford BRC by subscribing to our Mailchimp e-newsletter. It is produced several times a year and delivers news and information about upcoming events straight to your inbox.

Subscribe Now

Oxford BRC on Social Media

  • Facebook
  • LinkedIn
  • Twitter
  • YouTube

Feedback

We’d love to hear your feedback. Please contact us at obrcenquiries@ouh.nhs.uk

  • Sitemap
  • Data Control and Privacy
  • Accessibility
  • Our Partners
  • Disclaimer
  • Contact

Copyright © 2022 NIHR Oxford Biomedical Research Centre