NIHR Biomedical Research Centre: Oxford

Enabling translational research through partnership

NIHR 20th Anniversary NIHR website
NIHR Biomedical Research Centre: Oxford
  • Home
  • About
    • About us
    • Impact
    • Our next BRC
    • Steering Committee
    • Promoting equality, diversity and inclusion in research
    • Current Vacancies
    • Stay in Touch
    • Contact Us
  • Research
    • Research Overview
      • NIHR Clinical Research Facility
      • Ethics in the NIHR BRC: Oxford
      • Health Economics
      • Medical Statistics
    • Cancer
    • Cardiovascular Medicine
    • Digital Health from Hospital to Home
    • Gene and Cell Therapy
    • Genomic Medicine
    • Imaging
    • Inflammation across Tissues
    • Life-saving Vaccines
    • Metabolic Experimental Medicine
    • Modernising Medical Microbiology and Big Infection Diagnostics
      • Theme overview
      • Infections in Oxfordshire Database (IORD)
    • Musculoskeletal
    • Preventive Neurology
    • Respiratory Medicine
    • Surgical Innovation, Technology and Evaluation
    • Translational Data Science
  • Patient & Public Involvement
    • For patients and the public
    • For researchers
    • More information
  • Training
  • Industry & Partnerships
  • News
  • Events
  • Videos

Research Theme

IORD Project

A review of the current microbiology of prosthetic joint infections managed at the Bone Infection Unit (Nuffield Orthopaedic Centre, Oxford) to guide empirical antibiotic therapy choice

ONGOING
IORD category: Antimicrobial Resistance and Antibiotics, Specific Infections
Chief Investigator: Dr Bernadette Young
Sponsor: OUH
Research location: Oxford University
Approval date: 01 Sep 2025

Sometimes, people need a new hip or knee joint. This surgery usually helps, but in rare cases, the new joint can get infected. This is called a prosthetic joint infection.

These infections are serious and can cause pain, trouble walking, and more hospital visits. They can also be hard to treat.

Doctors usually treat these infections with another operation and a long course of antibiotics, but even then, the infection might not go away completely and can come back.

To choose the best antibiotic, doctors need to know what bacteria (germs) are causing the infection. It can take a few days to get this result, so doctors often start with antibiotics that work on the most common bacteria.

Over time, some bacteria have changed and become harder to kill with certain antibiotics. This is called antibiotic resistance, and it means that some of the usual antibiotics we use to treat infections don’t work anymore.

We want to study which bacteria are now causing these joint infections most often, and which antibiotics are still working to treat joint infections. This will help doctors to treat patients more effectively.

Modernising Medical Microbiology icon

Modernising Medical Microbiology and Big Infection Diagnostics

  • Theme overview
  • Sub-theme 1: Novel rapid, high-throughput diagnostic workflows for infection
  • Sub-theme 2: Big data-led infection diagnosis and management strategies
  • Contacts
  • Videos
  • News

Infections in Oxfordshire Research Database (IORD)

  • IORD Overview
    • What data is in IORD?
    • Different kinds of data in IORD
    • Who can use the data?
    • How do they get the data?
    • What do they do with the data?
    • What kind of questions has IORD answered? Why is this important?
    • What was it like before IORD?
    • Opting out
  • IORD Application Trajectory
  • IORD Projects
  • IORD Publications
  • IORD Privacy Notice
  • IORD Glossary
  • IORD FAQs
  • IORD Infographics
You are here: Home > IORD > A review of the current microbiology of prosthetic joint infections managed at the Bone Infection Unit (Nuffield Orthopaedic Centre, Oxford) to guide empirical antibiotic therapy choice

Subscribe to the BRC Oxford Newsletter

Keep informed about the work of the BRC Oxford by subscribing to our Mailchimp e-newsletter. It is produced several times a year and delivers news and information about upcoming events straight to your inbox.

Subscribe Now

Feedback

We’d love to hear your feedback. Please contact us at obrcenquiries@ouh.nhs.uk

BRC Oxford on Social Media

  • Bluesky
  • Facebook
  • LinkedIn
  • YouTube
  • Data Control and Privacy
  • Accessibility
  • Our Partners
  • Disclaimer
  • Contact

Copyright © 2026 NIHR Biomedical Research Centre: Oxford