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Research Theme

Modernising Medical Microbiology and Big Infection Diagnostics

Home > Research Themes Overview > Modernising Medical Microbiology and Big Infection Diagnostics > Infections in Oxfordshire Research Database > IORD Projects > Trends in bacterial pathogens, antibiotic resistance, antibiotic usage and patient outcomes in critical care in the Oxford University NHS Trust hospitals, 1999-2014

IORD Project

Trends in bacterial pathogens, antibiotic resistance, antibiotic usage and patient outcomes in critical care in the Oxford University NHS Trust hospitals, 1999-2014

COMPLETED
IORD category: Antimicrobial Resistance and Antibiotics, Electronic Health Records, Specific Pathogens
Chief Investigator: Dr Nicole Stoesser
Sponsor: OUH
Research location: Oxford University
Approval date: 12 Jan 2015

Antibiotics are medicines that are hugely important in treating many infections, and antibiotic resistance is a major clinical problem. Research has shown that increased use of antibiotics, whether appropriate or inappropriate, seems to be associated with higher numbers of antibiotic-resistant infections. To develop the best treatment strategies, it is important to understand which bacteria (bugs) are causing most infections and which antibiotics they are resistant to. This may vary in different hospital settings. Patients in critical care (intensive/high dependency care units) are particularly vulnerable to infections. There are however limited data on infections, antibiotic resistance and antibiotic usage in UK critical care units, and it is unclear: (i) what bugs are causing most infections in these patients; (ii) which antibiotics would be the best ones to use; and (iii) whether there is any change over time. This study would use the IORD database to answer these questions for critical care units in the OUH NHS Trust hospitals. We will look for links between antibiotic use, types of infection and common bugs, and whether this is different from other hospital wards. This information can be used to determine which antibiotic(s) is/are the best one(s) to use in critical care.

Modernising Medical Microbiology and Big Infection Diagnostics

  • Modernising Medical Microbiology and Big Infection Diagnostics
  • Sub-theme 1: Novel rapid, high-throughput diagnostic workflows for infection
  • Sub-theme 2: Big data-led infection diagnosis and management strategies
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