Four leading healthcare academics in Oxford have received a prestigious national award. The University of Oxford professors have been named National Institute of Health Research (NIHR) Senior Investigators in recognition of their “outstanding contribution to clinical and applied ... READ MORE
BRC-backed event increases understanding of open access research
As part of Open Access Week, the Oxford BRC in collaboration with the Bodleian Libraries have organised a training event for researchers on what open access is. Open access (OA) research papers are digital, online, free of charge and free of most copyright and licensing restrictions. It is made ... READ MORE
HIV remission achieved in second patient
A second person has experienced sustained remission from HIV-1 after ceasing treatment, ten years after the first such case. The case was reported in a paper to be published in Nature. Like the first such case, known as the ‘Berlin Patient’, the second patient was treated with stem ... READ MORE
Genes and height matter for carpal tunnel syndrome
Researchers from Oxford and Estonia have found further evidence that a person’s genetic make-up and height can influence whether they will develop carpal tunnel syndrome (CTS). In the first ever genome-wide association study of CTS, published today in Nature ... READ MORE
Oxford meeting looks at legacy of 100,000 Genomes Project and what comes next
A meeting involving clinicians, academics and patients has taken place in Oxford to celebrate the successes of the 100,000 Genomes Project and how genomic medicine becomes a routine part of NHS care in future. The meeting, held on 28 February, Rare Diseases Day, at the University of Oxford’s ... READ MORE
Patient involvement partnership sets priorities for rare inherited anaemias
On the occasion of Rare Diseases Day, marked every year on the last day of February, we are sharing this article about how patients, carers, clinicians and researchers are collaborating to decide key questions to shape future research into rare forms of anaemia. Patients with anaemia lack red ... READ MORE
Research identifies how the gut loses protective barrier function in IBD
A University of Oxford research team has used single-cell technology to identify new players in the gut epithelial barrier, the single-cell layer that forms the lining of the small and large intestine. The team from the MRC Human Immunology Unit (HIU), whose paper was published in the journal ... READ MORE
Low calorie meal replacements are a cost-effective routine treatment for obesity in the NHS
Replacing all regular meals with a low calorie diet of soups, shakes and bars, together with behavioural support, is cost-effective as a routine treatment for obesity, according to researchers from the University of Oxford. Published today in the journal Obesity, the study is the first to ... READ MORE
Risks of shoulder replacement surgery higher than previously thought
The risks associated with shoulder replacement surgery for arthritic conditions are higher than previously estimated, particularly for people under 60 and over 85 years old, according to a study supported by the NIHR Oxford BRC. The findings show that one in four men aged 55-59 years is at risk ... READ MORE
World’s first gene therapy operation for common cause of sight loss carried out
Researchers in Oxford have carried out the world’s first gene therapy operation to tackle the root cause of age-related macular degeneration (AMD), the UK’s most common cause of sight loss. The procedure was carried out at the John Radcliffe Hospital by Prof Robert MacLaren, Professor of ... READ MORE
New project to accelerate clinical trial recruitment
A new project, led by the University of Oxford, will use NHS data to accelerate recruitment into clinical trials and increase the opportunities for NHS patients to participate in research. Every NHS hospital keeps a detailed record of activities. A monthly report is sent to NHS Digital, who ... READ MORE
Only “modest” improvement in heart failure survival rates since 2000
Survival after a diagnosis of heart failure in the United Kingdom has shown only modest improvement in the 21st Century and lags behind other serious conditions, such as cancer, a large study supported by the Oxford Biomedical Research Centre has found. The findings, published by the BMJ, also ... READ MORE
Blog looks at Oxford BRC Health Impact symposium
In November 2018, the NIHR Oxford BRC jointly organised an international symposium to discuss how to maximise the impact of medical research. Some 87 delegates from eight countries took part in the symposium, ‘In the Trenches: Research Translation for Health Impact’, at Jesus College, ... READ MORE
New research to investigate role of blood-brain barrier in neurological conditions
A new consortium of 27 international partners from academia, industry, and small and medium enterprises, aims to tackle the unmet challenge of discovery and characterisation of blood-brain barrier targets and transport mechanisms for brain delivery of therapeutics to treat neurodegenerative ... READ MORE
Study suggests immune system plays key role in survival after pancreatic cancer surgery
Researchers in Oxford have found that an individual’s immune system – and in particular the presence of T-cells amongst tumour cells - may play an important role in survival after surgery to remove pancreatic cancer. The study by the University of Oxford’s Department of Oncology and Kennedy ... READ MORE
Oxford researchers develop new technique to analyse cancer cells’ life history
A team of researchers from the University of Oxford has developed a new technique that allows scientists to reliably track genetic errors in individual cancer cells, and find out how these might lead to uncontrollable growth. The research by the MRC Weatherall Institute of Molecular Medicine, ... READ MORE
Researchers worried that people with chronic disease are not active enough
A study of over 96,000 men and women in the UK, with an average age of 64.5 years, has found that those with chronic conditions are spending considerably less time on physical activity than their healthy peers, and so are missing out on its health management benefits. The ... READ MORE
Pills as good as injections to treat bone and joint infections, paper finds
Pills are just as effective as intravenous (IV) injections in tackling bone infections, a study led by Oxford-based researchers has found. The findings, published on 30 January in The New England Journal of Medicine, challenge the long-held belief that injections into the vein are the best way ... READ MORE
Largest-ever clinical trial in hip fracture fixation reaches key milestone
A randomised controlled trial comparing extracapsular hip fracture fixation devices, conducted by Oxford University and supported by NIHR Oxford Biomedical Research Centre, has reached a key milestone, with the 1000th patient recruited completing their one-year follow-up Recruitment for the ... READ MORE
Does general practice get a bad press?
Newspaper articles in the UK about general practice are currently very negative, and efforts should be stepped up to influence the media to provide a more balanced perspective, according to an Oxford BRC-supported study. The study by Eleanor Barry and Prof Trish Greenhalgh, of the University of ... READ MORE
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