Researchers from the NIHR Oxford Biomedical Research Centre (BRC) have developed a tool to rank and identify new gender equity markers specific to NIHR BRCs. In an article published in the PLOS ONE journal, the BRC researchers identified two distinct dimensions to monitoring gender ... READ MORE
Archives for 2020
Challenges around recruitment and retention in surgical trials highlighted
A study by Oxford BRC-supported researchers has identified the main challenges associated with the recruitment and retention of participants in surgical trials in the UK. The study was part of the PIRRIST project, which aims to enhance recruitment and retention in surgical trials by ... READ MORE
Prof Sarah Walker receives OBE
Professor Sarah Walker, the Oxford BRC’s Co-theme Lead for Antimicrobial Resistance and Modernising Microbiology, is to receive an OBE. Prof Walker, Professor of Medical Statistics and Epidemiology at the University of Oxford’s Nuffield Department of Medicine, was recognised for services to ... READ MORE
Hydroxychloroquine does not benefit hospitalised COVID-19 patients, RECOVERY Trial finds
Oxford scientists have confirmed that there is no clinical benefit from using hydroxychloroquine on COVID-19 patients in hospital. The findings were published in the New England Journal of Medicine. Hydroxychloroquine was one of the potential COVID-19 treatments being studied as part of the ... READ MORE
Hospitalised COVID-19 patients ‘younger and healthier than flu patients’
Patients hospitalised with COVID-19 were more likely male, younger and - in the US and Spain - had fewer comorbidities and lower medication use than hospitalized influenza patients according to a study published by the Observational Health Data Sciences and Informatics (OHDSI) community. This ... READ MORE
Patients with cirrhosis at increased risk of death from COVID-19, study finds
An international study led by researchers at Oxford University Hospitals NHS Foundation Trust has shown that patients with cirrhosis are at increased risk of dying as a result of COVID-19. The study, published in the Journal of Hepatology, found that mortality from COVID-19 was particularly ... READ MORE
New trial on use of anti-TNF drugs to treat Covid-19 in care homes
Researchers at the University of Oxford are starting a new study to explore the effectiveness of a common arthritis drug, adalimumab, as a treatment for patients with COVID-19 in the community, especially care homes. Recent studies of patients with COVID-19 have shown that patients already ... READ MORE
Evaluation of LamPORE rapid Covid-19 tests show high levels of diagnostic sensitivity
Scientists from the University of Oxford’s Nuffield Department of Medicine have today published their evaluation of LamPORE, a novel diagnostic platform for detecting SARS-CoV-2 RNA. This technology, which combines loop-mediated isothermal amplification with nanopore sequencing, has the ... READ MORE
Oxford assay excels in comparison of SARS-CoV-2 antibody tests
New research shows that, in a head-to-head comparison of five tests used to detect SARS-CoV-2 antibodies, an assay developed by an academic partnership led by the University of Oxford and one manufactured by Siemens had the most accurate results. The study comparing these ‘immunoassays’ has ... READ MORE
Key discovery in psoriatic arthritis points way for developing targeted treatments
A new study has revealed psoriatic arthritis may be activated by the same trigger in different patients. Researchers from the University of Oxford and the Wellcome Sanger Institute identified high levels of a specific receptor in immune cells from psoriatic arthritis patients, giving the ... READ MORE
NIHR health talks feature during Oxford IF festival
The Oxford BRC has joined with other parts of the local National Institute of Health Research infrastructure to organise a series of online talks as part of this year’s Oxford IF science and ideas festival. The talks, by leading Oxford researchers, cover a wide range of topics, from diabetes to ... READ MORE
‘Awake proning’ associated with improved COVID-19 clinical outcomes
A study by Oxford respiratory researchers has found that putting COVID-19 patients in a prone position can lead to improved outcomes. The findings of this retrospective study, supported by the NIHR Oxford Biomedical Research Centre, were published in an article by BMJ Open Respiratory ... READ MORE
RECOVERY Trial to test ‘antibody cocktail’
The RECOVERY Trial, the world’s largest randomised trial to find effective COVID-19 treatments, will evaluate the impact of an anti-viral antibody cocktail developed to tackle the virus. The announcement was made on 14 September by Regeneron Pharmaceuticals and the University of Oxford, which ... READ MORE
Persistent immune memory of COVID-19 found in recovered patient T cells
Oxford University researchers have found that infection with COVID-19 produces a robust T cell response, including inducing T cell ‘memory’ to potentially fight future infections. The results, published in Nature Immunology, are a joint effort from the Oxford COVID-19 immunology group, led ... READ MORE
Study explores COVID-19 outcomes for liver transplant patients
A study involving Oxford researchers has found that having had a liver transplant does not increase the risk of death from COVID-19, but that other factors such as age and comorbidities among liver transplant recipients do. The researchers from the Oxford Liver Unit, based at Oxford University ... READ MORE
Eight BRC projects get RCF funding
Eight Oxford BRC proposals, many covering a number of themes, have been awarded NIHR Research Capability Funding (RCF) funding to take forward key areas of research. The selected projects that will be supported include: Developing a research centre devoted to urgent and acute careThe ... READ MORE
Health economists outline possible criteria for allocating COVID-19 vaccine
NIHR Oxford BRC-supported health economics researchers have published a paper outlining the possible criteria that governments might use to prioritise who gets a COVID-19 vaccine once one has been approved for use. The article - ‘How Should a Safe and Effective COVID-19 Vaccine be Allocated? ... READ MORE
Low-dose corticosteroids found to reduce mortality in patients with severe COVID-19
Oxford patients, clinicians and researchers have contributed important data to new global research which shows that corticosteroids can significantly improve outcomes for severely ill patients with COVID-19. Four research papers published today in the Journal of the American Medical Association ... READ MORE
Research photography exhibition moves to Didcot
A photography exhibition showcasing ground-breaking NHS research taking place across the Thames Valley has opened in Didcot. ‘The Body Unlocked: How Research is Changing Lives’ features life-sized photographs of people who have taken part in studies, researchers at work and microscopic ... READ MORE
Hydroxychloroquine study finds increased cardiovascular risk with azithromycin
The combination of hydroxychloroquine (HCQ) and azithromycin (AZM) has been linked to significant cardiovascular risks, including mortality, in the largest safety study ever performed on both HCQ and HCQ+AZM. This network study, led by the Observational Health Data Sciences and Informatics ... READ MORE
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