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News Category: Infection

Antibiotics, not dirty hospitals, the main cause of C. difficile epidemic

Restricting the use of a common antibiotic was more important than a high profile “deep clean” of hospitals in massively reducing UK antibiotic resistant Clostridium difficile (C. diff) cases, a major new study has found. The study concluded that overuse of antibiotics like ciprofloxacin led to the outbreak of severe diarrhoea caused by C. difficile … Read more

Faster TB results from BRC-backed research

Whole Genome Sequencing is a faster, cheaper and more effective way of diagnosing tuberculosis, according to a new study published in the journal Lancet Respiratory Medicine. Dr Louise Pankhurst of the University of Oxford and a team of worldwide collaborators including Public Health England utilised innovative DNA technology to diagnose cases of tuberculosis (TB) up … Read more

Watch talk on antibiotic resistance

A public talk on the increasing prevalence of antimicrobial-resistant bacteria in hospitals and the community is now available to view online. Prof Angela Brueggemann spoke as part of a series of talks about research supported by the NIHR Oxford Biomedical Research Centre. Angela Brueggemann, Associate Professor at the University of Oxford’s Nuffield Department of Medicine, … Read more

New TB test to get sufferers on right drugs sooner

Tuberculosis sufferers will be able get drug treatment sooner thanks to a new whole genome sequencing technique to determine for the first time which drugs to give sufferers, researchers in Oxford have reported. University of Oxford researchers at the John Radcliffe Hospital have developed a genetic test – details of which are published online today … Read more

Restricting antibiotics could be key to fighting “superbug”

NEW WAYS are needed to fight the infection Clostridium difficile and better use of antibiotics could  be key, according to the authors of ground breaking research. In a unique study supported by the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, the team mapped all cases of Clostridium difficile (C.diff) in Oxfordshire over … Read more

TB’s genetic “family tree” may hold the key to tackling outbreaks quickly and effectively

NEW genetic sequencing techniques can map the “family tree” of a Tuberculosis (TB) outbreak allowing the spread of disease to be tackled quickly and effectively. Researchers, led by the NIHR Oxford Biomedical Research Centre, the Health Protection Agency in Birmingham and the Wellcome Trust Sanger Institute in Cambridge, have pioneered the whole genome sequencing (WGS) … Read more

High speed bench-top sequencing set to change the face of infection control

A study published today in BMJ Open, by researchers from Oxford, Leeds, Brighton and the Health Protection Agency, highlights the use of new bench-top DNA sequencers to quickly and cheaply unravel the entire genetic codes of bacteria causing life-threatening infections. This technology has the potential to revolutionise the speed and accuracy with which potential outbreaks … Read more

Genetic changes tracked as bacteria become a fatal infection

An unusual case could tell researchers more about the genetic changes that occur when a common bacteria, normally carried without any problems, on rare occasions causes potentially life-threatening infections. Eight mutations occurred in the common bacteria Staphylococcus aureus as it turned from an innocuous resident inside one person’s nose into a fatal blood infection, an … Read more

Oxford research sheds new light on Clostridium difficile infection in hospitals

It has been a widely held belief that most C. difficile infections are spread in hospital from a case with active disease to other patients. A recent study, funded by the National Institute of Health Research, in Oxford and Leeds however shows that the vast majority of C. difficile cases in hospital are isolated cases … Read more

How has the pneumococcus bacteria evolved after the introduction of a childhood vaccine?

Researchers from the University of Oxford and the US Centers for Disease Control and Prevention (CDC) used the latest DNA sequencing techniques to investigate how pneumococcus bacteria evolved after the introduction of a childhood vaccine in 2000 in the USA. Streptococcus pneumoniae infections are thought to kill around one million young children each year. Although … Read more

New two-drug approach to treat type of respiratory disease

A therapy combining two existing drugs could provide an effective new approach for treating patients with pleural infections, a serious condition where infected fluid builds up in the space between the ribs and lungs. A randomised clinical trial conducted by Oxford University researchers in the UK and published in the New England Journal of Medicine … Read more

What can be done about the rising risk of antibiotic resistance?

On December 11th 1945, at the end of his Nobel lecture, Alexander Fleming sounded a warning. Fleming’s chance observation of the antibiotic effects of a mould called Penicillium on one of his bacterial cultures had inspired his co-laureates, Howard Florey and Ernst Chain, two researchers based in Oxford, to extract the mould’s active principal and … Read more

Oxford group awarded millions to boost infection research

An Oxford group has today been chosen as one of two major consortia dedicated to research into healthcare associated infections and antibiotic resistance. The Oxford consortium comprises the Oxford Biomedical Research Centre (a partnership between the Oxford Radcliffe Hospitals and the University of Oxford), the Health Protection Agency, and the Wellcome Trust Sanger Institute. It … Read more