The NHS has launched the roll-out of the new Oxford AstraZeneca coronavirus vaccine, with patients at Oxford University Hospitals NHS Foundation Trust (OUH) the very first to get the life-saving jab. Among the first to be vaccinated was Prof Andrew Pollard, the Oxford BRC investigator who has ... READ MORE
COVID-19 News
IBD treatments do not increase susceptibility to COVID-19, study finds
Research by Oxford scientists has shown that rates of COVID-19 infection are not increased in patients with inflammatory bowel disease (IBD) who are being treated with the drugs infliximab or vedolizumab. The study data suggest there is no reason for treatment with these drugs to be ... READ MORE
Trial finds no benefit from azithromycin in hospitalised COVID-19 patients
The RECOVERY Trial, the world’s largest randomised trial of potential COVID-19 treatments, has found no convincing evidence that that the widely used antibiotic azithromycin has any meaningful clinical benefits for patients who have been hospitalised with COVID-19. Azithromycin was regarded a ... READ MORE
AI test rules out a COVID-19 diagnosis within one hour in A&E
An artificial intelligence test has been shown to be able to rapidly screen patients arriving in emergency departments for COVID-19, using clinical information routinely available within the first hour of coming to hospital. Results of the CURIAL study, published in The Lancet Digital Health, ... READ MORE
Peer-reviewed results of phase 3 Oxford coronavirus vaccine trial demonstrate efficacy
The vaccine against SARS-CoV-2 developed by researchers from the University of Oxford and AstraZeneca is safe and effective according to the peer-reviewed findings of the phase 3 trial. The pooled analysis of the trial across two different dose regimens resulted in an average efficacy of 70.4%; ... READ MORE
Hidden lung damage from COVID-19 revealed in new study
Early findings from a study into longer-term damage in patients recovering from COVID-19 suggest that cutting-edge scanning techniques may detect previously unseen lung damage. The research by the universities of Oxford and Sheffield is the first in Europe to use hyperpolarised Xenon gas with MRI ... READ MORE
Oxford University breakthrough on global COVID-19 vaccine
The University of Oxford, in collaboration with AstraZeneca plc, has announced interim trial data from its Phase III trials that shows its candidate vaccine, ChAdOx1 nCoV-2019, is effective at preventing COVID-19 and offers a high level of protection. The interim analysis indicates that the ... READ MORE
Prior COVID-19 infection offers protection from re-infection for at least six months
A new study suggests that individuals who have previously had COVID-19 are highly unlikely to contract the illness again, for at least six months following their first infection. The study, done as part of a major collaboration between the University of Oxford and Oxford University Hospitals (OUH) ... READ MORE
Interferon-b trial shows positive results
A trial of a new inhaled antiviral drug for COVID-19 has shown positive results and the drug is now moving into a larger international phase 3 trial of hospitalised patients, which is to be delivered with support from the NIHR. The new treatment, a protein called interferon beta or SNG001, has ... READ MORE
Possible predictors of COVID-19 severity identified
A study by researchers at the University of Oxford and Imperial College London have developed a checklist of potential predictors that someone may go on to develop a severe form of COVID-19. The paper, produced as part of the RECAP study, was published in the online open-access journal BMJ ... READ MORE
COVID antibodies wane within months, healthcare workers study shows
Antibodies to COVID-19 fall by half in less than 90 days, and antibody levels peak lower and fall faster in younger adults, an ongoing study of staff at Oxford University Hospitals NHS Foundation Trust has revealed. The findings, published on the pre-print server medRxiv, also showed that ... READ MORE
Minimal risk of catching COVID-19 as a result of endoscopy, study finds
More than 6,000 patients who underwent endoscopy at 18 NHS hospitals since the start of pandemic have been tested and none contracted COVID as a result of the procedure, a study involving clinicians from Oxford University Hospitals (OUH) NHS Foundation Trust has found. Clinicians hope the ... READ MORE
Oxford study reveals medium-term impact of COVID-19
Initial findings from a study looking at the longer-term impact of COVID-19 have shown that a large proportion of COVID-19 patients discharged from hospital were still experiencing symptoms of breathlessness, fatigue, anxiety and depression two to three months after contracting the virus. The ... READ MORE
Prof Sarah Walker receives OBE
Professor Sarah Walker, the Oxford BRC’s Co-theme Lead for Antimicrobial Resistance and Modernising Microbiology, is to receive an OBE. Prof Walker, Professor of Medical Statistics and Epidemiology at the University of Oxford’s Nuffield Department of Medicine, was recognised for services to ... READ MORE
Hydroxychloroquine does not benefit hospitalised COVID-19 patients, RECOVERY Trial finds
Oxford scientists have confirmed that there is no clinical benefit from using hydroxychloroquine on COVID-19 patients in hospital. The findings were published in the New England Journal of Medicine. Hydroxychloroquine was one of the potential COVID-19 treatments being studied as part of the ... READ MORE
Hospitalised COVID-19 patients ‘younger and healthier than flu patients’
Patients hospitalised with COVID-19 were more likely male, younger and - in the US and Spain - had fewer comorbidities and lower medication use than hospitalized influenza patients according to a study published by the Observational Health Data Sciences and Informatics (OHDSI) community. This ... READ MORE
Patients with cirrhosis at increased risk of death from COVID-19, study finds
An international study led by researchers at Oxford University Hospitals NHS Foundation Trust has shown that patients with cirrhosis are at increased risk of dying as a result of COVID-19. The study, published in the Journal of Hepatology, found that mortality from COVID-19 was particularly ... READ MORE
New trial on use of anti-TNF drugs to treat Covid-19 in care homes
Researchers at the University of Oxford are starting a new study to explore the effectiveness of a common arthritis drug, adalimumab, as a treatment for patients with COVID-19 in the community, especially care homes. Recent studies of patients with COVID-19 have shown that patients already ... READ MORE
Evaluation of LamPORE rapid Covid-19 tests show high levels of diagnostic sensitivity
Scientists from the University of Oxford’s Nuffield Department of Medicine have today published their evaluation of LamPORE, a novel diagnostic platform for detecting SARS-CoV-2 RNA. This technology, which combines loop-mediated isothermal amplification with nanopore sequencing, has the ... READ MORE
Oxford assay excels in comparison of SARS-CoV-2 antibody tests
New research shows that, in a head-to-head comparison of five tests used to detect SARS-CoV-2 antibodies, an assay developed by an academic partnership led by the University of Oxford and one manufactured by Siemens had the most accurate results. The study comparing these ‘immunoassays’ has ... READ MORE
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