For the first time, a comprehensive database comprising an initial cohort of more than 1,300 patients with chronic hepatitis B or hepatitis C infections has been developed for potential future research into the conditions. The methodology to develop a pipeline to collect and manage this data ... READ MORE
Peer-reviewed results of phase 3 Oxford coronavirus vaccine trial demonstrate efficacy
The vaccine against SARS-CoV-2 developed by researchers from the University of Oxford and AstraZeneca is safe and effective according to the peer-reviewed findings of the phase 3 trial. The pooled analysis of the trial across two different dose regimens resulted in an average efficacy of 70.4%; ... READ MORE
Hidden lung damage from COVID-19 revealed in new study
Early findings from a study into longer-term damage in patients recovering from COVID-19 suggest that cutting-edge scanning techniques may detect previously unseen lung damage. The research by the universities of Oxford and Sheffield is the first in Europe to use hyperpolarised Xenon gas with MRI ... READ MORE
Using AI to improve the quality of endoscopy videos
A multidisciplinary team of researchers has developed a deep-learning framework for improving endoscopy to aid the detection of cancer and other gastrointestinal diseases. Cancers detected at an earlier stage have a much higher chance of being treated successfully. The main method for ... READ MORE
New melanoma drug a step closer to the clinic
A new anti-tumour immune response drug for patients with metastatic melanoma has given positive results in clinical trials conducted by the University of Oxford and the UK biotech company Immunocore. The trials into the use of tebentafusp for metastatic uveal melanoma mean the drug could now be ... READ MORE
Oxford University breakthrough on global COVID-19 vaccine
The University of Oxford, in collaboration with AstraZeneca plc, has announced interim trial data from its Phase III trials that shows its candidate vaccine, ChAdOx1 nCoV-2019, is effective at preventing COVID-19 and offers a high level of protection. The interim analysis indicates that the ... READ MORE
Prior COVID-19 infection offers protection from re-infection for at least six months
A new study suggests that individuals who have previously had COVID-19 are highly unlikely to contract the illness again, for at least six months following their first infection. The study, done as part of a major collaboration between the University of Oxford and Oxford University Hospitals (OUH) ... READ MORE
Interferon-b trial shows positive results
A trial of a new inhaled antiviral drug for COVID-19 has shown positive results and the drug is now moving into a larger international phase 3 trial of hospitalised patients, which is to be delivered with support from the NIHR. The new treatment, a protein called interferon beta or SNG001, has ... READ MORE
Possible predictors of COVID-19 severity identified
A study by researchers at the University of Oxford and Imperial College London have developed a checklist of potential predictors that someone may go on to develop a severe form of COVID-19. The paper, produced as part of the RECAP study, was published in the online open-access journal BMJ ... READ MORE
Study looks at role of digital technology in tackling lockdown loneliness
A study by Oxford BRC researchers has looked at the role digital technology can play in reducing social, physical and psychological risks during the COVID-19 pandemic, and addressing the short- and long-term impacts of social isolation and lockdown loneliness. Their paper, published in the ... READ MORE
COVID antibodies wane within months, healthcare workers study shows
Antibodies to COVID-19 fall by half in less than 90 days, and antibody levels peak lower and fall faster in younger adults, an ongoing study of staff at Oxford University Hospitals NHS Foundation Trust has revealed. The findings, published on the pre-print server medRxiv, also showed that ... READ MORE
Analysis shows that funding gender equity incentives can work
A paper by Oxford BRC-supported researchers says that linking research funding to Athena SWAN gender equality action plans has been associated with a rise in the number of women in mid-level leadership positions and the proportion of funding going to women. The paper, published in the BMJ, said ... READ MORE
$410 million buy-out for Oxford cancer detection technology
Oxford biotechnology spin-out company Base Genomics has been acquired by the US early cancer detection company Exact Sciences for $410 million. Base Genomics, which was launched in June 2020, is based on Dr Chunxiao Song’s innovative TET-assisted pyridine borane sequencing (TAPS) ... READ MORE
Research photography exhibition comes to John Radcliffe Hospital
A photography exhibition showcasing ground-breaking NHS research taking place across the Thames Valley can now be viewed by visitors and staff at Oxford’s John Radcliffe Hospital. ‘The Body Unlocked: How Research is Changing Lives’ features life-sized photographs of people who have taken ... READ MORE
Minimal risk of catching COVID-19 as a result of endoscopy, study finds
More than 6,000 patients who underwent endoscopy at 18 NHS hospitals since the start of pandemic have been tested and none contracted COVID as a result of the procedure, a study involving clinicians from Oxford University Hospitals (OUH) NHS Foundation Trust has found. Clinicians hope the ... READ MORE
Researchers develop tool to monitor gender equity in Biomedical Research Centres
Researchers from the NIHR Oxford Biomedical Research Centre (BRC) have developed a tool to rank and identify new gender equity markers specific to NIHR BRCs. In an article published in the PLOS ONE journal, the BRC researchers identified two distinct dimensions to monitoring gender ... READ MORE
Challenges around recruitment and retention in surgical trials highlighted
A study by Oxford BRC-supported researchers has identified the main challenges associated with the recruitment and retention of participants in surgical trials in the UK. The study was part of the PIRRIST project, which aims to enhance recruitment and retention in surgical trials by ... READ MORE
Prof Sarah Walker receives OBE
Professor Sarah Walker, the Oxford BRC’s Co-theme Lead for Antimicrobial Resistance and Modernising Microbiology, is to receive an OBE. Prof Walker, Professor of Medical Statistics and Epidemiology at the University of Oxford’s Nuffield Department of Medicine, was recognised for services to ... READ MORE
Hydroxychloroquine does not benefit hospitalised COVID-19 patients, RECOVERY Trial finds
Oxford scientists have confirmed that there is no clinical benefit from using hydroxychloroquine on COVID-19 patients in hospital. The findings were published in the New England Journal of Medicine. Hydroxychloroquine was one of the potential COVID-19 treatments being studied as part of the ... READ MORE
Hospitalised COVID-19 patients ‘younger and healthier than flu patients’
Patients hospitalised with COVID-19 were more likely male, younger and - in the US and Spain - had fewer comorbidities and lower medication use than hospitalized influenza patients according to a study published by the Observational Health Data Sciences and Informatics (OHDSI) community. This ... READ MORE
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