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RECOVERY Trial to test ‘antibody cocktail’

14 September 2020 · Listed under COVID-19, Translational Data Science

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The RECOVERY Trial, the world’s largest randomised trial to find effective COVID-19 treatments, will evaluate the impact of an anti-viral antibody cocktail developed to tackle the virus. The announcement was made on 14 September by Regeneron Pharmaceuticals and the University of Oxford, which ... READ MORE

Persistent immune memory of COVID-19 found in recovered patient T cells

10 September 2020 · Listed under COVID-19, Inflammation across Tissues

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Oxford University researchers have found that infection with COVID-19 produces a robust T cell response, including inducing T cell ‘memory’ to potentially fight future infections. The results, published in Nature Immunology, are a joint effort from the Oxford COVID-19 immunology group, led ... READ MORE

Study explores COVID-19 outcomes for liver transplant patients

8 September 2020 · Listed under Other News

A study involving Oxford researchers has found that having had a liver transplant does not increase the risk of death from COVID-19, but that other factors such as age and comorbidities among liver transplant recipients do. The researchers from the Oxford Liver Unit, based at Oxford University ... READ MORE

Eight BRC projects get RCF funding

7 September 2020 · Listed under Cancer, Cardiovascular Medicine, Digital Health from Hospital to Home, Gene and Cell Therapy, Genomic Medicine, Imaging, Inflammation across Tissues, Metabolic Experimental Medicine, Molecular Diagnostics, Multimorbidity and Long-Term Conditions, Preventive Neurology, Surgical Innovation, Technology and Evaluation, Translational Data Science

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Eight Oxford BRC proposals, many covering a number of themes, have been awarded NIHR Research Capability Funding (RCF) funding to take forward key areas of research. The selected projects that will be supported include: Developing a research centre devoted to urgent and acute careThe ... READ MORE

Health economists outline possible criteria for allocating COVID-19 vaccine

3 September 2020 · Listed under Life-saving Vaccines

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NIHR Oxford BRC-supported health economics researchers have published a paper outlining the possible criteria that governments might use to prioritise who gets a COVID-19 vaccine once one has been approved for use. The article - ‘How Should a Safe and Effective COVID-19 Vaccine be Allocated? ... READ MORE

Low-dose corticosteroids found to reduce mortality in patients with severe COVID-19

2 September 2020 · Listed under COVID-19, Translational Data Science

Oxford patients, clinicians and researchers have contributed important data to new global research which shows that corticosteroids can significantly improve outcomes for severely ill patients with COVID-19. Four research papers published today in the Journal of the American Medical Association ... READ MORE

Research photography exhibition moves to Didcot

1 September 2020 · Listed under Other News, Patient and Public Involvement and Engagement

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A photography exhibition showcasing ground-breaking NHS research taking place across the Thames Valley has opened in Didcot.  ‘The Body Unlocked: How Research is Changing Lives’ features life-sized photographs of people who have taken part in studies, researchers at work and microscopic ... READ MORE

Hydroxychloroquine study finds increased cardiovascular risk with azithromycin

24 August 2020 · Listed under COVID-19, Musculoskeletal, Translational Data Science

The combination of hydroxychloroquine (HCQ) and azithromycin (AZM) has been linked to significant cardiovascular risks, including mortality, in the largest safety study ever performed on both HCQ and HCQ+AZM. This network study, led by the Observational Health Data Sciences and Informatics ... READ MORE

Test developed to identify new-borns at risk of leukaemia

21 August 2020 · Listed under Gene and Cell Therapy, Molecular Diagnostics

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Oxford researchers have developed a new method to quickly identify cancerous cells in babies at risk of leukaemia. The team hope that the new protocol could make rapid testing more accessible for clinical laboratories around the globe. Until now, the only reliable way to know if a baby with ... READ MORE

Paper outlines management of post-acute COVID-19 in primary care

11 August 2020 · Listed under COVID-19, Industry & Partnerships

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A new article published in the BMJ has mapped out what is known and what is still unknown about ‘long COVID’, where patients COVID-19 patients continue to experience symptoms many weeks after contracting the virus. The article, co-authored by the NIHR Oxford BRC’s Theme Lead for Partnerships ... READ MORE

Common heart medication does not increase risk of COVID-19 hospitalisation

10 August 2020 · Listed under Cardiovascular Medicine, COVID-19, Digital Health from Hospital to Home, Translational Data Science

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A study by Oxford researchers, supported by the NIHR Oxford Biomedical Research Centre (BRC), found that ACE inhibitors and ARBs – both common treatments for high blood pressure and heart failure – are not generally linked to an increased risk of severe COVID-19 disease or an increased likelihood of ... READ MORE

BRC gets European funding for citizen science metabolism project

7 August 2020 · Listed under Metabolic Experimental Medicine

The NIHR Oxford Biomedical Research Centre (BRC) has received more than €270,000 from the European Commission as a part of a multi-nation research project to promote citizen science. Oxford’s involvement will entail the BRC and the Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM) ... READ MORE

Oxford University and ZOE partner on COVID-19 treatment trials

3 August 2020 · Listed under COVID-19, Multimorbidity and Long-Term Conditions, Respiratory Medicine

The University of Oxford has joined forces with the COVID Symptom Study app to widen access to two clinical trials of potential treatments for COVID-19.  The two trials include the STOIC trial, which is supported by the NIHR Oxford BRC. Run by the University’s Nuffield Department of Medicine ... READ MORE

Study maps role CD8 T cells play in IBD

3 August 2020 · Listed under Inflammation across Tissues

Researchers in Oxford using an ‘atlas’ of immune cells in the human colon have found evidence of the role of CD8 T cells in inflammatory bowel disease (IBD). The findings could lead to a better understanding of how cells behave and interact in people with IBD, and could pave the way for more ... READ MORE

Mild COVID-19 symptoms might not result in positive antibody test, research finds

31 July 2020 · Listed under COVID-19, Modernising Medical Microbiology and Big Infection Diagnostics, Translational Data Science

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Oxford researchers have found that COVID-19 antibody tests might not give a positive result if people have only had mild symptoms, like loss of taste and smell. Microbiology and data experts from the Oxford University Hospitals (OUH) NHS Foundation Trust and the University of Oxford made the ... READ MORE

BRC researchers’ work recognised with Vice-Chancellor’s Awards

30 July 2020 · Listed under Life-saving Vaccines, Molecular Diagnostics, Surgical Innovation, Technology and Evaluation

A number of Oxford BRC-supported researchers have been recognised in this year’s University of Oxford Vice-Chancellor Innovation Awards. The Vice-Chancellor Innovation Awards celebrate research-led innovation that is having societal or economic impact. Prof Robert MacLaren, who leads the BRC’s ... READ MORE

AI test identifies COVID-19 within an hour in emergency departments

30 July 2020 · Listed under COVID-19, Modernising Medical Microbiology and Big Infection Diagnostics, Translational Data Science

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University of Oxford scientists specialising in infectious disease and clinical machine learning have developed an artificial intelligence test that can rapidly screen for COVID-19 in patients arriving in emergency departments. The initial findings of the ‘CURIAL’ AI test, which has been ... READ MORE

Photography exhibition on NHS research comes to Newbury

22 July 2020 · Listed under Other News, Patient and Public Involvement and Engagement

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A travelling photography exhibition showcasing ground-breaking NHS research taking place across the Thames Valley has opened in Newbury.  The exhibition, ‘The Body Unlocked: How Research is Changing Lives’, consists of two metre-high panels featuring people who have taken part in studies, ... READ MORE

New treatment reduces COVID-19 patients needing intensive care

20 July 2020 · Listed under Respiratory Medicine

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The preliminary results of a clinical trial supported by NIHR Oxford BRC researchers have suggested that a new treatment for COVID-19 dramatically reduces the number of patients needing intensive care. The treatment, a protein called interferon beta, has been developed by the UK biotech company ... READ MORE

Oxford coronavirus vaccine produces strong immune response, study finds

20 July 2020 · Listed under Life-saving Vaccines

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A team of scientists at Oxford University’s Jenner Institute and Oxford Vaccine Group has taken the next step towards the discovery of a safe, effective and accessible vaccine against coronavirus. The results of the Phase I/II trial, published today in The Lancet, indicate no early safety ... READ MORE

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