Researchers at the University of Oxford have discovered that the most common liver disease follows a strong day-night pattern, and the metabolic changes that drive the disease are most pronounced overnight, when the body is least able to process sugar and fat. Furthermore, they found that these ... READ MORE
New NIHR Oxford Senior Research Fellows named
Eight mid-career researchers identified as having the potential to become future translational research leaders have been appointed as the next cohort of NIHR Oxford Senior Research Fellows. The selection process was a coordinated effort by the NIHR Oxford Biomedical Research Centre (BRC) and ... READ MORE
Oxford team treats first patient in ground-breaking retinal gene therapy trial
The first patient has been treated in Oxford in the second phase of an international clinical trial testing a new gene therapy for Stargardt disease - a rare inherited eye condition that leads to progressive vision loss and eventually blindness in children and adults. The ASTRA trial is ... READ MORE
Stopping weight-loss drugs linked to faster regain than ending diet programmes, review finds
People tend to regain weight rapidly after stopping weight-loss drugs – and faster than after ending behavioural weight loss programmes – according to a new systematic review and meta-analysis from the University of Oxford published in The BMJ. The findings come as real-world data shows around ... READ MORE
Oxford recruits first patient in Europe for heart inflammation treatment study
An international clinical trial to test a potential treatment for people with coronary inflammation has got under way at Oxford University Hospitals. The FORTIFY study was launched at the Acute Multidisciplinary Imaging and Interventional Centre (AMIIC), a state-of-the-art facility within the ... READ MORE
International study to tackle moderate asthma launched
An international clinical trial involving the University of Oxford which aims to use an innovative new approach to tackle moderate asthma has been launched thanks to a 10 million Canadian dollars grant from the biopharmaceutical company Sanofi and its partner Regeneron. The HOTHOT trial, which ... READ MORE
First volunteer receives Lassa fever vaccine in cutting-edge Oxford trial
The first volunteer has received a dose in a first-in-human trial of a vaccine developed in Oxford against Lassa fever, marking a major milestone in the fight against the deadly virus. The trial, conducted by the Oxford Vaccine Group, and funded by the Coalition for Epidemic Preparedness ... READ MORE
Can AI models rival humans in anonymising patient data?
Researchers from the University of Oxford have benchmarked artificial intelligence (AI) tools capable of automatically removing personal information from patient electronic health records in a key step towards enabling large-scale, confidential medical research. As healthcare becomes digitised, ... READ MORE
Blood test predicts risk of death in acutely ill children in lower-income countries
An international study has identified a blood-based indicator of intestinal damage and inflammation that strongly predicts mortality in sick children. The new biomarker could help to identify those children at greatest risk of dying after hospitalisation in parts of the world with limited ... READ MORE
BRC senior researcher appointed to help tackle health inequalities in Oxfordshire
Dr Joanna Crocker, the NIHR Oxford Biomedical Research Centre’s Senior Researcher for Patient and Public Involvement has been appointed Chief Scientific Advisor to lead community-engaged research tackling health inequalities in Oxfordshire. Dr Crocker (pictured right) is one of three Chief ... READ MORE
Unique UK re-audit of upper gastrointestinal bleeding highlights progress
A major UK-wide audit has shown significant improvements in outcomes for patients admitted to hospital with acute upper gastrointestinal bleeding – and highlighted clear areas for further progress. This re-audit, which followed an earlier audit in 2007, was led from Oxford, conducted by experts ... READ MORE
Oxford and GSK launch Experimental Medicine Collaboration
The pharmaceutical multinational GSK is investing £10 million over five years to establish the Experimental Medicine Collaboration with the University of Oxford. The GSK and University of Oxford Experimental Medicine Collaboration (EMC) is a pioneering partnership that aims to redefine the ... READ MORE
Scientists map cells that drive Crohn’s disease fistulas, paving way for targeted treatments
Scientists at the University of Oxford, have identified how rare populations of abnormal cells drive the formation and persistence of fistulas – painful, tunnel-like tracts that develop in around 30% of people with Crohn’s disease. Crohn’s disease is a long-term disease that affects around one ... READ MORE
Oxford-led study shows vaccine protection against Paratyphoid
Results from a newly published study show that a vaccine can protect people against Salmonella Paratyphi A infection. The Oxford-led study demonstrated that an oral live-attenuated vaccine, CVD 1902, provided significant protection against S. Paratyphi A infection in healthy ... READ MORE
Almost 70% of bowel cancers missed at colonoscopy are avoidable
A major nationwide study has revealed that the majority of bowel cancers diagnosed late, after a false-negative colonoscopy could have been prevented or detected earlier. The study, published in Endoscopy, was supported by the National Institute for Health and Care Research (NIHR) Oxford ... READ MORE
World’s largest hip fracture research platform launched to improve care and outcomes
Taking an innovative approach to clinical research in hip fracture, the World Hip Trauma Evaluation (WHiTE) Platform Trial has been launched to test multiple new treatments for patients with fractures of the hip. Hip fractures are a major global health challenge, with 1.3 million cases per year ... READ MORE
Oxford team develops new national course for all UK surgical trainees
A new national online surgical research course designed to equip every surgical trainee in the UK with the skills to critically engage with, and contribute to, surgical research has been developed in Oxford. The National Online Teaching Programme (NOTP) Surgical Research Course provides core ... READ MORE
Underweight children cost NHS as much per child as those with obesity, study finds
The NHS incurs an estimated £340 million in additional healthcare costs annually due to weight-related health problems in children – but it is not just obesity driving the costs. New research from the University of Oxford reveals that underweight children need comparable medical support as ... READ MORE
Towards inclusive sleep science
An Oxford academic paper that suggests current sleep scoring criteria may lead to biased results between sexes and across age groups has been brought back into the spotlight with a recent editorial and podcast. A recent editorial by Prof Monika Haack of Harvard Medical School, published in the ... READ MORE
Oxford researchers pioneer new breathing test to detect lung disease earlier
A new project led by the University of Oxford aims to develop a novel breathing test that could detect asthma and COPD earlier, more accurately, and closer to home, reducing pressure on the NHS and improving outcomes for patients. This work is included in a portfolio of research funded by the ... READ MORE
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