The NIHR Oxford BRC’s Gene and Cell Therapy Theme has organised its second workshop to discuss how researchers from a range of disciplines are using new CRISPR gene editing tools or applying CRISPR to their research in innovative ways. The workshop, held on 4 July at Merton College in Oxford, ... READ MORE
News Archive
Glowing dye helps surgeons eradicate prostate cancer
A glowing marker dye that sticks to prostate cancer cells could help surgeons to remove them in real-time, according to new research. Scientists at the University of Oxford and Oxford University Hospitals NHS Foundation Trust, supported by Cancer Research UK and the NIHR Oxford Biomedical ... READ MORE
Viagra drug improves brain blood flow and could help to prevent dementia
A University of Oxford trial has shown that sildenafil, commonly known as Viagra, enhances blood flow to the brain and improves the function of brain blood vessels in patients at a heightened risk of vascular dementia. This new study, published in Circulation Research and supported ... READ MORE
Heart scans could help thousands avoid unnecessary invasive procedure
Thousands of patients admitted to hospital every year with suspected heart attacks could avoid an unnecessary invasive procedure if they have a routine heart MRI scan first, according to new research. The study, funded by the NIHR Oxford Biomedical Research Centre (BRC) and British Heart ... READ MORE
AI analysis of heart scans predicts risk of developing heart problems ten years in advance
A University of Oxford research team has developed an artificial intelligence (AI) technology which can accurately predict the risk of a heart attack, heart failure or cardiac death from routine cardiac CT scans, up to ten years in advance. The study, funded by the British Heart Foundation and ... READ MORE
Study outlines feasibility of multiple disease risk prediction model for primary care
A team of researchers have found that a single, integrated health check carried out in a primary care setting can accurately predict risks for diseases across multiple organs. Currently, GPs are often limited to assessing the risk of diseases one at a time, a process that is ... READ MORE
Hiding in plain sight: study identifies cryptic disease-causing genetic variants not detected by standard testing
Researchers in Oxford have identified types of genetic variants that lead to a range of rare disease but are not picked up by standard genetic testing. The team at the University of Oxford’s Centre for Human Genetics analysed whole genome sequencing data from the 100,000 Genomes Project. They ... READ MORE
Importance of early blood glucose control for people with type 2 diabetes highlighted
Research led by scientists from the Universities of Oxford and Edinburgh has found that early good blood glucose control can minimise the lifetime risk of diabetes-related complications, including heart attacks, kidney failure and vision loss. These latest results from the UK Prospective ... READ MORE
Study identifies ways cancer treatment may lead to harmful side effects
A team of University of Oxford researchers have identified potential pathways by which cancer treatment can cause colitis. Checkpoint inhibitors (CPIs) are a type of cancer treatment that help the immune system fight cancer by removing some of its restraints. However, these treatments ... READ MORE
New Maternity Early Warning Score to be implemented across the NHS
Researchers in Oxford have developed a new maternity early warning score that is derived from patient data. The new system, which is being rolled out across the English NHS, will help healthcare providers identify and respond to signs of deterioration in pregnant women. Maternity Early Warning ... READ MORE
Funding announced for hepatitis C controlled human infection model trial
A proposed groundbreaking study that will see participants infected with hepatitis C - and treated - has secured more than £1million in funding. The study will help pave the way for future testing of hepatitis C vaccine candidates. The £1,098,103 funding from the research and grant-making ... READ MORE
New study to improve vaccines and therapeutics development
A first-of-its-kind study led by the University of Oxford has successfully investigated human immunity against COVID-19 in people who already have antibodies against it. The results suggest that previous infection, together with vaccination, offers strong protection against the original ... READ MORE
Study sheds light on debate around shoulder replacement surgery for osteoarthritis
A new study has provided valuable insights into the ongoing debate surrounding two types of shoulder replacement surgery as a treatment for patients with osteoarthritis: reverse total shoulder replacement and anatomical total shoulder replacement. The study, published in the BMJ and funded by ... READ MORE
NHS baby check may miss dislocated hips in new-born babies
A new study has identified that NHS infant checks can miss serious hip abnormalities in new-born babies. Left undetected, these can require complex surgery, and lead to early arthritis. The study, published by the JAMA Network, was led by researchers at the University of Liverpool in ... READ MORE
Breakthrough aerosol human infection model gives hope for future TB vaccine development
University of Oxford researchers have for the first time established a controlled human infection model for tuberculosis (TB) that infects people via the lungs – the way TB enters the body. The clinical trial, which used the BCG vaccine delivered via aerosol into participants’ lungs, is a first ... READ MORE
New study reveals long-term mental health risks after COVID-19
A new study has shed light on the long-term mental health consequences of COVID-19 infection and the growing evidence of the protective effect of vaccination on reducing the risk. The research, supported by the NIHR Oxford Biomedical Research Centre (BRC), was conducted in a population-based ... READ MORE
Study assesses new MRI technique to detect liver cancer
Oxford researchers have been awarded funding to conduct a study comparing a new type of MRI (Magnetic resonance imaging) to standard of care ultrasound for liver cancer surveillance in people with cirrhosis. The University of Oxford’s DeLIVER team, which is investigating early detection methods ... READ MORE
Oxford BRC researcher named NIHR Senior Investigator
NIHR Oxford BRC researcher Professor Ronjon Chakraverty has received a prestigious national research award. Professor Chakraverty, Professor of Haematology in the Radcliffe Department of Medicine and Oxford BRC Co-theme Lead for Gene and Cell Therapy, was named a National Institute of Health ... READ MORE
New bronchoscopy capability expands capacity for respiratory and vaccine trials
The NIHR Oxford Clinical Research Facility (EMCRF) has expanded its capability to undertake research bronchoscopies and welcomed its first volunteers as part of the Oxford Airways Study, which is supported by the NIHR Oxford Biomedical Research Centre, to help understand the causes of ... READ MORE
COVID jab linked to lower risk of COVID-19-related clot and heart complications
The risk of cardiac and clot-related complications following COVID-19 is substantially reduced in people who receive the COVID-19 vaccination, compared with unvaccinated individuals, according to new research. The observational study, which was supported by the NIHR Oxford Biomedical Research ... READ MORE
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