Scientists from the Universities of Oxford and Sheffield are collaborating with the US biopharmaceutical company Sparrow Pharmaceuticals on DC-MACS a Phase 2 clinical study of the drug clofutriben to treat autonomous cortisol secretion (ACS). Clofutriben, also known as SPI-62, is produced by ... READ MORE
News Archive
Wearable devices can help predict five-year risk of falls for people with Parkinson’s
University of Oxford researchers have demonstrated how clinicians could use data to predict the risk of falls in people with Parkinson’s disease (PD) to help improve effective longer-term care planning. Falls are a common problem for people living with Parkinson’s. A recent review estimated ... READ MORE
Machine learning outperforms surgeons in predicting knee replacement outcomes
A new study has revealed that machine learning models can significantly outperform experienced surgeons in predicting patient outcomes after partial knee replacement. Unicompartmental (partial) knee replacement (UKR) is a common procedure designed to relieve pain in patients with knee ... READ MORE
Oxford professor named among world’s top 100 ophthalmologists
The Oxford BRC’s Theme Lead for Gene and Cell Therapy, Professor Robert MacLaren, has been ranked in the top 100 ophthalmologists worldwide for 2024 by the international Ophthalmologist magazine. The ranking was based on votes from key leaders across ophthalmology, academia and ... READ MORE
First new treatment for asthma attacks in 50 years
An injection given during some asthma and chronic obstructive pulmonary disease (COPD) attacks is more effective than the current treatment of steroid tablets, reducing the need for further treatment by 30 percent. The findings, published in The Lancet Respiratory Medicine, could be ... READ MORE
Amoxicillin is effective for many people hospitalised with pneumonia
Amoxicillin, a narrow-spectrum antibiotic, has been found to be as effective as the broad-spectrum antibiotic co-amoxiclav, which targets a wider range of bacteria, in people admitted to hospital with pneumonia, regardless of how severe it is. In a paper published in the Journal of Infection, a ... READ MORE
Lowering the barriers to participation in brain imaging research
Oxford BRC-supported researchers have produced videos aimed at increasing the diversity of participants taking part in brain imaging research studies. These ‘what to expect’ videos are part of a wider project by the BRC’s Imaging Theme and the University of Oxford’s Wellcome Centre for ... READ MORE
Oxford researchers awarded £11m to address antimicrobial resistance
The National Institute for Health and Care Research (NIHR) has awarded the University of Oxford £11 million to address the major public health threat of antimicrobial resistance. The Oxford Health Protection Research Unit (HPRU) in Healthcare Associated Infections and Antimicrobial Resistance ... READ MORE
Study charts course for next generation of drug targets in autoimmune diseases
In a world first, researchers in Oxford have mapped the cellular dynamics following treatment with the most commonly used advanced therapy in autoimmune diseases. They have discovered why some patients benefit from this therapy while others do not, potentially paving the way for new therapies. ... READ MORE
New biomarker and therapeutic target identified for blood cancers
Researchers in Oxford have identified a protein as a key marker for disease progression and a promising therapeutic target for patients with a type of blood cancer. In a study published in Science Translational Medicine, the team at the University of Oxford’s MRC Molecular Haematology ... READ MORE
Damage to brain’s ‘control centre’ behind long-lasting COVID-19 symptoms, MRI scans show
Damage to the brainstem – the brain’s ‘control centre’ – is behind long-lasting physical and psychiatric effects of severe COVID-19 infection, a study has suggested. Using ultra-high-resolution scanners that can see the living brain in fine detail, researchers from the Universities of Cambridge ... READ MORE
Funding awarded for world’s first ovarian cancer prevention vaccine
Oxford researchers have been awarded up to £600,000 from Cancer Research UK (CRUK) to create the world’s first vaccine to prevent ovarian cancer. Scientists at the University of Oxford’s MRC Weatherall Institute of Molecular Medicine (MRC-WIMM), led by Professor Ahmed Ahmed, are designing ... READ MORE
New campaign launched to encourage vaccine uptake
Parents are being urged to get their children vaccinated as part of a campaign to boost uptake in the UK amid rising cases of whooping cough and measles. Researchers at the Oxford Vaccine Group, which is part of the University of Oxford and supported by the NIHR Oxford Biomedical Research Centre ... READ MORE
Study increases understanding of lung microbiome in severe asthma patients
Respiratory researchers in Oxford have discovered a link between potentially pathogenic bacteria and airways inflammation in severe asthma. The team, who are supported by the NIHR Oxford Biomedical Research Centre (BRC), used long-read genome sequencing on sputum and nasal lavage samples from ... READ MORE
BLOG: How we’ve succeeded in recruiting older hospital patients onto our trial
Professor Sarah Pendlebury, from the NIHR Oxford BRC’s Preventive Neurology Theme, and Dr Aubretia McColl, of the Wolfson Centre for Prevention of Stroke and Dementia, explain how they have tackled the challenge of recruiting older, frail patients with multiple conditions to trials within ... READ MORE
Study reveals previously unknown genetic causes of colorectal cancer
A pioneering study has provided the most comprehensive analysis to date of the genetic make-up of colorectal cancer. The study, which was supported by the NIHR Oxford Biomedical Research Centre, involved the Universities of Oxford, Manchester, Birmingham, Edinburghand Leeds, The Institute of ... READ MORE
UK’s most ambitious melanoma research study created for patients, by patients
“Any melanoma patient can be part of it. You don’t have to go into a hospital, you don’t have to live near a university that’s active in research, all you need is access to the internet.” Kelly Norman, patient representative MyMelanoma is an online-based research project for melanoma ... READ MORE
Research identifies autoimmunity against a key anti-inflammatory regulator in IBD
A ground-breaking study has identified a new disease-inducing mechanism for inflammatory bowel disease (IBD) in which the immune system attacks its own regulatory function. Interleukin-10 (IL10) is an anti-inflammatory protein that crucially controls intestinal immunity. Children with genetic ... READ MORE
Prediction model could help inform patients of shoulder replacement surgery risks
A new model to predict the risk of serious complications after shoulder replacement surgery has been developed in a collaboration between researchers from Oxford, Bristol and Copenhagen. The model could be an important tool to help patients and doctors make more informed decisions about this common ... READ MORE
Patient story – Kathryn Hedigan, EXPLAIN study
Kathryn Hedigan took part in the EXPLAIN study, which used hyperpolarised xenon MRI scans to investigate possible lung damage in long COVID patients who had not been hospitalised with COVID-19 but who continued to experience breathlessness. Kathryn, aged 66, lives near Burford in West ... READ MORE
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