Infection prevention and control clinicians and researchers at Oxford University Hospitals (OUH) have been outlining the OUH’s experience of deploying self-administered home-based lateral flow testing of its staff. In a letter published in the Journal of Infection, they said that 46,503 ... READ MORE
Drug trial that could improve respiratory recovery from COVID-19 under way
A clinical trial has begun to test whether the drug Almitrine can help people who are seriously ill with COVID-19 recover from the disease. Oxford University Hospitals NHS Foundation Trust is one of three centres taking part in the trial. Patients suffering from COVID-19 pneumonia often ... READ MORE
Common asthma treatment reduces need for hospitalisation in COVID-19 patients, study suggests
Early treatment with a medication commonly used to treat asthma appears to significantly reduce the need for urgent care and hospitalisation in people with COVID-19, researchers at the University of Oxford have found. The STOIC study found that inhaled budesonide given to patients with COVID-19 ... READ MORE
Machine learning system developed to identify deteriorating patients in hospital
Researchers in Oxford have developed a machine learning algorithm that could significantly improve clinicians’ ability to identify hospitalised patients whose condition is deteriorating to the extent that they need intensive care. The HAVEN system was developed as part of a collaboration ... READ MORE
Oxford coronavirus vaccine shows sustained protection between doses
Researchers at the University of Oxford have revealed that the efficacy of the Oxford/AstraZeneca coronavirus vaccine is higher at longer prime-boost intervals, and that a single dose of the vaccine is 76% effective from 22 to up to 90 days post-vaccination. In their findings, published in ... READ MORE
Fewer colorectal cancer diagnoses reported during COVID-19
University of Oxford researchers from the UK Colorectal Cancer Intelligence Hub have been investigating how the diagnosis and treatment of colorectal cancer patients has been affected by the COVID-19 pandemic. The NIHR Oxford BRC-supported researchers at the Nuffield Department of Population ... READ MORE
Oxford researchers meet patients to discuss new Advanced Cellular Therapies Centre
Oxford researchers have met with members of the Oxford Blood Group to discuss plans for an Advanced Cellular Therapies Centre. Plans for the creation of an Oxford Advanced Cellular Therapies Centre have been supported by NIHR Research Capability Funding. The proposed centre will bring together ... READ MORE
Genetic breakthrough to target care for deadly heart condition
University of Oxford researchers have discovered a new type of genetic change in the DNA of people with the inherited heart condition hypertrophic cardiomyopathy, the leading cause of sudden cardiac death in young people. The findings, in a paper published in Nature Genetics, could transform ... READ MORE
Lateral flow devices detect most infectious COVID-19 cases, study shows
Researchers from the University of Oxford, working with Public Health England, have used NHS Test and Trace data to find out why some individuals pass COVID-19 on to their contacts more easily than others, and if lateral flow tests are sufficient in detecting those who are most ... READ MORE
COVID-19 ‘matching service’ increased public involvement in research, HRA finds
The Health Research Authority (HRA) has found that levels of public involvement in COVID-19 research increased following the introduction of a public involvement matching service, in a report published last week. A group of public contributors from the NIHR Oxford Biomedical Research Centre took ... READ MORE
Classification system uncovers new information about ovarian cancers
An Oxford-based ovarian cancer specialist has published a paper outlining a new classification which categorises different subtypes of cells and determines which ones can lead to more severe cancer outcomes. This approach, dubbed the ‘Oxford Classification of Carcinoma of the Ovary’ or ‘Oxford ... READ MORE
Ancient gene mutation found to cause rare hereditary condition
UK scientists have found that a 7,000-year-old genetic mutation is responsible for a rare form of hereditary motor neuropathy (HMN). In a paper, published in the journal Brain, geneticists and clinicians from the University of Oxford and University College London who led the international study ... READ MORE
Oxford study confirms medium-term impact of COVID-19
A study looking at the longer-term impact of COVID-19 has found that a significant proportion of COVID-19 patients discharged from hospital reported symptoms of breathlessness, fatigue and depression and had limited exercise capacity several weeks after leaving hospital. The University of ... READ MORE
Paper urges use of genomics in care of monogenic IBD
Gastroenterology experts have had a position paper published that calls for genomic technologies to be considered an integral part of patient care to investigate patients at risk for monogenic forms of inflammatory bowel disease (IBD). The authors include a number of NIHR Oxford BRC-supported ... READ MORE
Oxford COVID-19 vaccinations begin
The NHS has launched the roll-out of the new Oxford AstraZeneca coronavirus vaccine, with patients at Oxford University Hospitals NHS Foundation Trust (OUH) the very first to get the life-saving jab. Among the first to be vaccinated was Prof Andrew Pollard, the Oxford BRC investigator who has ... READ MORE
IBD treatments do not increase susceptibility to COVID-19, study finds
Research by Oxford scientists has shown that rates of COVID-19 infection are not increased in patients with inflammatory bowel disease (IBD) who are being treated with the drugs infliximab or vedolizumab. The study data suggest there is no reason for treatment with these drugs to be ... READ MORE
Trial finds no benefit from azithromycin in hospitalised COVID-19 patients
The RECOVERY Trial, the world’s largest randomised trial of potential COVID-19 treatments, has found no convincing evidence that that the widely used antibiotic azithromycin has any meaningful clinical benefits for patients who have been hospitalised with COVID-19. Azithromycin was regarded a ... READ MORE
AI test rules out a COVID-19 diagnosis within one hour in A&E
An artificial intelligence test has been shown to be able to rapidly screen patients arriving in emergency departments for COVID-19, using clinical information routinely available within the first hour of coming to hospital. Results of the CURIAL study, published in The Lancet Digital Health, ... READ MORE
Key step for hepatitis research as patient database created
For the first time, a comprehensive database comprising an initial cohort of more than 1,300 patients with chronic hepatitis B or hepatitis C infections has been developed for potential future research into the conditions. The methodology to develop a pipeline to collect and manage this data ... READ MORE
Peer-reviewed results of phase 3 Oxford coronavirus vaccine trial demonstrate efficacy
The vaccine against SARS-CoV-2 developed by researchers from the University of Oxford and AstraZeneca is safe and effective according to the peer-reviewed findings of the phase 3 trial. The pooled analysis of the trial across two different dose regimens resulted in an average efficacy of 70.4%; ... READ MORE
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