Oxford researchers have met with members of the Oxford Blood Group to discuss plans for an Advanced Cellular Therapies Centre. Plans for the creation of an Oxford Advanced Cellular Therapies Centre have been supported by NIHR Research Capability Funding. The proposed centre will bring together ... READ MORE
News Archive
Genetic breakthrough to target care for deadly heart condition
University of Oxford researchers have discovered a new type of genetic change in the DNA of people with the inherited heart condition hypertrophic cardiomyopathy, the leading cause of sudden cardiac death in young people. The findings, in a paper published in Nature Genetics, could transform ... READ MORE
Lateral flow devices detect most infectious COVID-19 cases, study shows
Researchers from the University of Oxford, working with Public Health England, have used NHS Test and Trace data to find out why some individuals pass COVID-19 on to their contacts more easily than others, and if lateral flow tests are sufficient in detecting those who are most ... READ MORE
COVID-19 ‘matching service’ increased public involvement in research, HRA finds
The Health Research Authority (HRA) has found that levels of public involvement in COVID-19 research increased following the introduction of a public involvement matching service, in a report published last week. A group of public contributors from the NIHR Oxford Biomedical Research Centre took ... READ MORE
Classification system uncovers new information about ovarian cancers
An Oxford-based ovarian cancer specialist has published a paper outlining a new classification which categorises different subtypes of cells and determines which ones can lead to more severe cancer outcomes. This approach, dubbed the ‘Oxford Classification of Carcinoma of the Ovary’ or ‘Oxford ... READ MORE
Ancient gene mutation found to cause rare hereditary condition
UK scientists have found that a 7,000-year-old genetic mutation is responsible for a rare form of hereditary motor neuropathy (HMN). In a paper, published in the journal Brain, geneticists and clinicians from the University of Oxford and University College London who led the international study ... READ MORE
Oxford study confirms medium-term impact of COVID-19
A study looking at the longer-term impact of COVID-19 has found that a significant proportion of COVID-19 patients discharged from hospital reported symptoms of breathlessness, fatigue and depression and had limited exercise capacity several weeks after leaving hospital. The University of ... READ MORE
Paper urges use of genomics in care of monogenic IBD
Gastroenterology experts have had a position paper published that calls for genomic technologies to be considered an integral part of patient care to investigate patients at risk for monogenic forms of inflammatory bowel disease (IBD). The authors include a number of NIHR Oxford BRC-supported ... READ MORE
Oxford COVID-19 vaccinations begin
The NHS has launched the roll-out of the new Oxford AstraZeneca coronavirus vaccine, with patients at Oxford University Hospitals NHS Foundation Trust (OUH) the very first to get the life-saving jab. Among the first to be vaccinated was Prof Andrew Pollard, the Oxford BRC investigator who has ... READ MORE
IBD treatments do not increase susceptibility to COVID-19, study finds
Research by Oxford scientists has shown that rates of COVID-19 infection are not increased in patients with inflammatory bowel disease (IBD) who are being treated with the drugs infliximab or vedolizumab. The study data suggest there is no reason for treatment with these drugs to be ... READ MORE
Trial finds no benefit from azithromycin in hospitalised COVID-19 patients
The RECOVERY Trial, the world’s largest randomised trial of potential COVID-19 treatments, has found no convincing evidence that that the widely used antibiotic azithromycin has any meaningful clinical benefits for patients who have been hospitalised with COVID-19. Azithromycin was regarded a ... READ MORE
AI test rules out a COVID-19 diagnosis within one hour in A&E
An artificial intelligence test has been shown to be able to rapidly screen patients arriving in emergency departments for COVID-19, using clinical information routinely available within the first hour of coming to hospital. Results of the CURIAL study, published in The Lancet Digital Health, ... READ MORE
Key step for hepatitis research as patient database created
For the first time, a comprehensive database comprising an initial cohort of more than 1,300 patients with chronic hepatitis B or hepatitis C infections has been developed for potential future research into the conditions. The methodology to develop a pipeline to collect and manage this data ... READ MORE
Peer-reviewed results of phase 3 Oxford coronavirus vaccine trial demonstrate efficacy
The vaccine against SARS-CoV-2 developed by researchers from the University of Oxford and AstraZeneca is safe and effective according to the peer-reviewed findings of the phase 3 trial. The pooled analysis of the trial across two different dose regimens resulted in an average efficacy of 70.4%; ... READ MORE
Hidden lung damage from COVID-19 revealed in new study
Early findings from a study into longer-term damage in patients recovering from COVID-19 suggest that cutting-edge scanning techniques may detect previously unseen lung damage. The research by the universities of Oxford and Sheffield is the first in Europe to use hyperpolarised Xenon gas with MRI ... READ MORE
Using AI to improve the quality of endoscopy videos
A multidisciplinary team of researchers has developed a deep-learning framework for improving endoscopy to aid the detection of cancer and other gastrointestinal diseases. Cancers detected at an earlier stage have a much higher chance of being treated successfully. The main method for ... READ MORE
New melanoma drug a step closer to the clinic
A new anti-tumour immune response drug for patients with metastatic melanoma has given positive results in clinical trials conducted by the University of Oxford and the UK biotech company Immunocore. The trials into the use of tebentafusp for metastatic uveal melanoma mean the drug could now be ... READ MORE
Oxford University breakthrough on global COVID-19 vaccine
The University of Oxford, in collaboration with AstraZeneca plc, has announced interim trial data from its Phase III trials that shows its candidate vaccine, ChAdOx1 nCoV-2019, is effective at preventing COVID-19 and offers a high level of protection. The interim analysis indicates that the ... READ MORE
Prior COVID-19 infection offers protection from re-infection for at least six months
A new study suggests that individuals who have previously had COVID-19 are highly unlikely to contract the illness again, for at least six months following their first infection. The study, done as part of a major collaboration between the University of Oxford and Oxford University Hospitals (OUH) ... READ MORE
Interferon-b trial shows positive results
A trial of a new inhaled antiviral drug for COVID-19 has shown positive results and the drug is now moving into a larger international phase 3 trial of hospitalised patients, which is to be delivered with support from the NIHR. The new treatment, a protein called interferon beta or SNG001, has ... READ MORE
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