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You are here: Home > Clinical Informatics and Big Data > RECOVERY Trial launched in South Africa

RECOVERY Trial launched in South Africa

9 December 2021 · Listed under Clinical Informatics and Big Data, COVID-19

The world’s largest clinical trial investigating treatments for COVID-19 has now been launched in South Africa, with the first patient recruited today.

Since March 2020, the RECOVERY Trial, which is supported by the NIHR Oxford BRC, has discovered three effective treatments for COVID-19: the inexpensive steroid dexamethasone; the arthritis drug tocilizumab; and a monoclonal antibody treatment, now known as Ronapreve. As the pandemic continues to affect both high- and lower-income countries, treatments are needed that are suitable for a wide range of patients and healthcare systems.

Sir Peter Horby, Professor of Emerging Infectious Diseases in the University of Oxford’s Nuffield Department of Medicine and Joint Chief Investigator of RECOVERY, said: “I am absolutely delighted that South Africa has joined RECOVERY.

“South African scientists, medical professionals and patients have already made an enormous contribution in the fight against COVID. By working together on RECOVERY we hope to further accelerate progress towards finding globally relevant solutions to this terrible disease.”

South Africa is the fifth country to take part in RECOVERY, joining Nepal, Indonesia, Vietnam and the United Kingdom.

Emmanuelle Denis, who liaises between the Oxford-based RECOVERY team and investigators outside the UK, said: “We are very excited to be expanding RECOVERY into South Africa in collaboration with Wits Health Consortium and the University of Cape Town. Expanding RECOVERY recruitment to Africa will help to further the continent’s capacity to conduct adaptive streamlined clinical trials and will provide important insights into the effectiveness of study treatments in a different patient population.”

In South Africa, RECOVERY will initially focus on whether using a higher dose of the anti-inflammatory treatment dexamethasone (compared to standard doses of the drug previously shown to save lives in the RECOVERY trial) has an even greater effect.

The hospital sites taking part include major academic hospitals in Johannesburg, Cape Town, Bloemfontein and Durban, ensuring that a good mix of COVID-19 patients will have the opportunity to enrol in the trial. All participants will receive the usual care in the participating hospitals.

RECOVERY and other randomised trials have demonstrated the benefit of corticosteroids such as dexamethasone for patients with inadequate levels of oxygen (hypoxia), whilst other randomised clinical trials in critically ill COVID-19 patients have used higher doses of dexamethasone and reported clinical benefit. However, the higher doses have not been compared with the lower dose used in RECOVERY, and so there is uncertainty regarding the best dose for hospitalised patients.

Higher doses of corticosteroids are used to control inflammatory processes in other illnesses, including bacterial meningitis, tuberculous meningitis, and community acquired pneumonia; they may be beneficial for COVID-19 patients and could offer an alternative treatment option for clinicians.

Funding for RECOVERY International was provided by Wellcome, in collaboration with the UK Foreign, Commonwealth and Development Office, on behalf of the COVID-19 Therapeutics Accelerator, initially for a two-year period. This has already supported the expansion of the trial into Vietnam, Nepal and Indonesia.

← Blog: the implications of the OxVALVE-Survive study on GP practice
COVID-19 infection more likely than vaccines to cause rare cardiovascular complications →

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