NIHR Oxford Biomedical Research Centre

Enabling translational research through partnership

MENUMENU
  • About
    • About the NIHR Oxford Biomedical Research Centre
    • NIHR Oxford BRC impact
    • Steering Committee
    • Promoting equality, diversity and inclusion in research
    • Current Vacancies
    • Stay in Touch
    • Contact Us
  • Research

        • Research Overview
        • Clinical Research Facility
        • Health Economics
        • Ethics in the NIHR Oxford BRC
        • Medical Statistics
        • Infections in Oxfordshire Database (IORD)
        • 15 Research Themes

        • Cancer
        • Cardiovascular Medicine
        • Digital Health from Hospital to Home
        • Gene and Cell Therapy
        • Genomic Medicine
        • Imaging
        • Inflammation across Tissues
        • Life-saving Vaccines
        • Metabolic Experimental Medicine
        • Modernising Medical Microbiology and Big Infection Diagnostics
        • Musculoskeletal
        • Preventive Neurology
        • Respiratory Medicine
        • Surgical Innovation, Technology and Evaluation
        • Translational Data Science
  • Patient and Public Involvement
    • For patients and the public
    • For researchers
    • More information
  • Training Hub
    • Training Hub Overview
    • Clinical Academic Pathway
    • Internships
    • Pre-doctoral Research Fellowships
    • Senior Research Fellowships
    • Research Training Bursaries
    • Doctoral Awards
    • Post-Doctoral Awards
    • PARC Programme
    • Other funding
    • Leadership Training
    • Useful Links
    • Training and Education Resources
    • Upcoming Training Events & Courses
  • Industry
    • Collaborate with Oxford BRC
    • Who Do We Work With?
    • Events
    • Further Information and Additional Resources
    • Contacts for Industry
  • Videos
  • News
  • Events
Research Theme

Modernising Medical Microbiology and Big Infection Diagnostics

Infections in Oxfordshire Database (IORD)
Home > Research Themes Overview > Modernising Medical Microbiology and Big Infection Diagnostics > Infections in Oxfordshire Research Database > IORD Projects > Review of short course intravenous antibiotics (less than 72 hours) for the treatment of community-onset Gram-negative (Enterobacterales) bacteraemia

IORD Project

Review of short course intravenous antibiotics (less than 72 hours) for the treatment of community-onset Gram-negative (Enterobacterales) bacteraemia

ONGOING
IORD category: Antimicrobial Resistance and Antibiotics
Chief Investigator: Prof David Eyre
Sponsor: OUH
Research location: Oxford University
Approval date: 13 Aug 2025

Blood cultures are a test sent from unwell patients with serious infections that are used to detect if bacteria are present in their blood. Blood taken from patients is taken to a laboratory where any bacteria that are present are grown, or ‘cultured’.

These blood cultures help find the cause of the infection and guide treatment. Gram-negative bacteria are a group of organisms that cause severe infections including sepsis and may be detected in blood cultures. Normally blood does not contain any bacteria, and so when these Gram-negative bacteria are found in the blood, they are usually considered important and in need of treatment with antibiotics.

Many doctors around the world routinely treat blood infections caused by Gram-negative bacteria with antibiotics through a drip for 3 days or more before switching to tablet antibiotics. In Oxfordshire, patients are often switched to tablet antibiotics much sooner. We want to investigate if this early switching to tablet antibiotics is safe and effective.

MODERNISING MEDICAL MICROBIOLOGY AND BIG INFECTION DIAGNOSTICS →

Infections in Oxfordshire Database (IORD)

  • IORD Overview
    • What data is in IORD?
    • Different kinds of data in IORD
    • Who can use the data?
    • How do they get the data?
    • What do they do with the data?
    • What kind of questions has IORD answered? Why is this important?
    • What was it like before IORD?
    • Opting out
  • IORD Application Trajectory
  • IORD Projects
  • IORD Publications
  • IORD Privacy Notice
  • IORD Glossary
  • IORD FAQs
  • IORD Infographics

Subscribe to the Oxford BRC Newsletter

Keep informed about the work of the Oxford BRC by subscribing to our Mailchimp e-newsletter. It is produced several times a year and delivers news and information about upcoming events straight to your inbox.

Subscribe Now

Feedback

We’d love to hear your feedback. Please contact us at obrcenquiries@ouh.nhs.uk

Oxford BRC on Social Media

  • Bluesky
  • Facebook
  • LinkedIn
  • YouTube
  • Data Control and Privacy
  • Accessibility
  • Our Partners
  • Disclaimer
  • Contact

Copyright © 2025 NIHR Oxford Biomedical Research Centre