We are studying the mechanisms that increase the risk of type 2 diabetes through the disruption of circadian rhythms, for example as a result of shift work.
We are also evaluating the use of low carbohydrate diets in patients with T2D and assessing how they interact with the metabolism.
In the past we have conducted a number of studies to better understand and devise treatments for type 2 diabetes, including total diet replacement, low carbohydrate diets, drug and digital support. We are using data and clinical samples from these studies – as well as ongoing large-scale cardiovascular trials EXSCEL and TECOS – to identify factors that might indicate how a patient will respond to different treatments and how complications might develop.
Oxford BRC academics Professors Susan Jebb and Paul Aveyard are leading a major project, NewDAWN, aimed at giving more people newly diagnosed with type 2 diabetes the chance of going into remission.