NIHR Oxford Biomedical Research Centre

Enabling translational research through partnership

MENUMENU
  • About
    • About the NIHR Oxford Biomedical Research Centre
    • NIHR Oxford BRC impact
    • Steering Committee
    • Promoting equality, diversity and inclusion in research
    • Current Vacancies
    • Stay in Touch
    • Contact Us
  • Research

        • Research Overview
        • Clinical Research Facility
        • Health Economics
        • Ethics in the NIHR Oxford BRC
        • Medical Statistics
        • Infections in Oxfordshire Database (IORD)
        • 15 Research Themes

        • Cancer
        • Cardiovascular Medicine
        • Digital Health from Hospital to Home
        • Gene and Cell Therapy
        • Genomic Medicine
        • Imaging
        • Inflammation across Tissues
        • Life-saving Vaccines
        • Metabolic Experimental Medicine
        • Modernising Medical Microbiology and Big Infection Diagnostics
        • Musculoskeletal
        • Preventive Neurology
        • Respiratory Medicine
        • Surgical Innovation, Technology and Evaluation
        • Translational Data Science
  • Patient and Public Involvement
    • For patients and the public
    • For researchers
    • More information
  • Training Hub
    • Training Hub Overview
    • Clinical Academic Pathway
    • Internships
    • Pre-doctoral Research Fellowships
    • Senior Research Fellowships
    • Research Training Bursaries
    • Doctoral Awards
    • Post-Doctoral Awards
    • PARC Programme
    • Other funding
    • Leadership Training
    • Useful Links
    • Training and Education Resources
    • Upcoming Training Events & Courses
  • Industry
    • Collaborate with Oxford BRC
    • Who Do We Work With?
    • Events
    • Further Information and Additional Resources
    • Contacts for Industry
  • Videos
  • News
  • Events

News

You are here: Home > Musculoskeletal > Platelet rich plasma found to be of no benefit in treating torn Achilles tendon

Platelet rich plasma found to be of no benefit in treating torn Achilles tendon

13 December 2019 · Listed under Musculoskeletal

New research from the University of Oxford has shown that platelet rich plasma (PRP) is not effective in treating acute Achilles tendon ruptures.

Photo by Nino Liverani on Unsplash

The Achilles tendon is the most common tendon rupture treated in hospitals. Patients face long periods unable to work or participate in sport as healing and recovery are slow.

With PRP therapy, a concentrate of the patient’s own blood containing high levels of platelets and growth factors important for healing, is injected into the Achilles injury site. There have been promising signs from laboratory research that PRP could improve healing. Its popularity has already grown in sports and orthopaedic medicine and notably in high-profile athletes.

However, the researchers from the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS) in a carefully controlled study found no evidence that PRP injections improved muscle-tendon function or the patients’ quality of life after this injury.

It was a multi-centre randomised placebo-controlled trial, the first robust study investigating whether PRP would improve recovery. Participants and assessors were blind to the treatment they had received.

Dr David Keene, a lead author of the BMJ report, said: “After many years of careful development, trialling and evaluation, the PATH-2 trial results showed that when subjected to robust evaluation, there was no evidence of patient benefit from injecting high quality PRP for acute Achilles tendon ruptures.”

Prof Keith Willett, the Chief Investigator for the PATH-2 research programme said: “We aim to provide the best care possible to patients, underpinned by excellent research. This is an important negative finding.  The clinical community now needs to determine whether the use of PRP for other injuries and conditions is justified and, for the torn Achilles tendon, focus on other therapies.”

The PATH-2 trial was funded by the Efficacy and Mechanism Evaluation programme, a Medical Research Council (MRC) and National Institute for Health Research (NIHR) partnership and supported by the NIHR Oxford Biomedical Research Centre, was published in the BMJ on 20 November.

In the study, 230 adult patients with non-surgical management of an Achilles rupture were randomised – half having an injection of PRP, the rest having a dry needle inserted as a placebo. All the patients received standard rehabilitation care, consisting of ankle immobilisation, followed by physiotherapy. The final assessment was carried out after 24 weeks.

The main finding was that there was no difference in the amount of work the injured calf muscle and tendon could generate with or without PRP. There was also no difference in levels of pain, symptoms and physical function, or other patient-reported outcomes between the two groups throughout the study.

← NIHR Oxford BRC Senior Research Fellows named
New trauma wound treatment no better than standard dressing →

Other news

News Categories

News by Month

See all news

Subscribe to the Oxford BRC Newsletter

Keep informed about the work of the Oxford BRC by subscribing to our Mailchimp e-newsletter. It is produced several times a year and delivers news and information about upcoming events straight to your inbox.

Subscribe Now

Feedback

We’d love to hear your feedback. Please contact us at [email protected]

Oxford BRC on Social Media

  • Bluesky
  • Facebook
  • LinkedIn
  • Threads
  • Twitter
  • YouTube
  • Data Control and Privacy
  • Accessibility
  • Our Partners
  • Disclaimer
  • Contact

Copyright © 2025 NIHR Oxford Biomedical Research Centre