NIHR Oxford Biomedical Research Centre

Enabling translational research through partnership

MENUMENU
  • About
    • About the NIHR Oxford Biomedical Research Centre
    • NIHR Oxford BRC impact
    • Steering Committee
    • Promoting equality, diversity and inclusion in research
    • Current Vacancies
    • Stay in Touch
    • Contact Us
  • Research

        • Research Overview
        • Clinical Research Facility
        • Health Economics
        • Ethics in the NIHR Oxford BRC
        • Medical Statistics
        • Infections in Oxfordshire Database (IORD)
        • 15 Research Themes

        • Cancer
        • Cardiovascular Medicine
        • Digital Health from Hospital to Home
        • Gene and Cell Therapy
        • Genomic Medicine
        • Imaging
        • Inflammation across Tissues
        • Life-saving Vaccines
        • Metabolic Experimental Medicine
        • Modernising Medical Microbiology and Big Infection Diagnostics
        • Musculoskeletal
        • Preventive Neurology
        • Respiratory Medicine
        • Surgical Innovation, Technology and Evaluation
        • Translational Data Science
  • Patient and Public Involvement
    • For patients and the public
    • For researchers
    • More information
  • Training Hub
    • Training Hub Overview
    • Clinical Academic Pathway
    • Internships
    • Pre-doctoral Research Fellowships
    • Senior Research Fellowships
    • Research Training Bursaries
    • Doctoral Awards
    • Post-Doctoral Awards
    • PARC Programme
    • Other funding
    • Leadership Training
    • Useful Links
    • Training and Education Resources
    • Upcoming Training Events & Courses
  • Industry
    • Collaborate with Oxford BRC
    • Who Do We Work With?
    • Events
    • Further Information and Additional Resources
    • Contacts for Industry
  • Videos
  • News
  • Events

News

You are here: Home > Musculoskeletal > New trauma wound treatment no better than standard dressing

New trauma wound treatment no better than standard dressing

11 February 2020 · Listed under Musculoskeletal

A study by Oxford researchers has shown that a new method of treating wounds after major trauma is no more effective at improving surgical infection rates than cheaper standard dressings.

The findings, by a team at the Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences (NDORMS) at the University of Oxford, could save NHS millions of pounds.

The research was supported by the NIHR Oxford Biomedical Research Centre (BRC).

Major trauma, commonly associated with serious limb injuries such as fractured bones, is the leading worldwide cause of death in people under 45 years of age, and a significant cause of short- and long-term disability. Treatment of these fractures is complicated because soft-tissue around the bone is also badly damaged.

Healing is often complicated by deep infections, but this risk can be reduced by the type of dressing applied over the wound at the end of the operation.

Negative pressure wound therapy (NPWT), which involves applying gentle suction to the surface of the wound as it heals, is a relatively new treatment that has provided promising early results in patients with surgical wounds associated with major trauma.

However, a The NDORMS study found that the use of incisional negative pressure wound therapy, compared with standard wound dressing, resulted in no significant difference in the rate of deep surgical site infection (SSI).

NPWT typically costs nearly £150 per dressing, due to the extra cost of suction pumps, while a standard wound dressing is priced at less than £2.

Each year the NHS spends between £4.5 and £5.1bn on wound management. Exact figures on the number of NPWT dressings currently being used in the NHS is difficult to estimate, according to the researchers, who are due to publish a further economic analysis of the treatments later this year.

Professor Matthew Costa

Lead author Professor Matthew Costa (pictured right) said: “Negative pressure wound therapy offered the prospect of reducing patients’ risk of wound infection. However, we needed to be sure about this because the new dressings are more expensive than the current standard care.

“In the largest study of its kind we found no evidence that negative pressure dressings reduced the risk of deep infection in the surgical wound. The negative pressure dressings were very unlikely to be cost effective. This is important because the NHS spends millions of pounds on wound dressings each year. Using less costly standard treatment will mean savings for the NHS without compromising patient outcomes.”

Professor Jason Madan from Warwick Medical School was the lead health economist for the WHIST trial. He said: “Our trial-based economic evaluation found no meaningful difference in health-related quality of life between those who received negative pressure wound therapy and those who didn’t. If the NHS stays with standard treatment, patients will be just as healthy, and the money that would have been spent on negative pressure wound therapy can be used in other ways that do improve patients’ health.”

The randomised clinical trial included 1,548 participants each given either NPWT, or standard wound dressing, and the primary outcome measure was deep surgical site infection at 30 days. The research found no significant difference in the infection rate in the NPWT group at 5.84% and in the standard dressing group at 6.68%.

Professor Hywel Williams, Director of the NIHR Health Technology Assessment (HTA) Programme, which funded the research, said: “This large study shows that the new technique of negative pressure wound therapy offers no advantage for reducing deep infections from lower limb fractures compared with standard wound dressings. Stopping their use in this situation could free up resources for the NHS to use elsewhere.

“When most people think of research they usually think of developing new cures and tech innovations, but this valuable study shows that research into existing innovations that are being increasingly used in the NHS can be just as important.”   

The results of the trial were published in the Journal of the American Medical Association (JAMA).

Results of the study are also being considered by the National Wound Care Strategy Programme as part of their evidence-based recommendations in developing guidelines for the use of NPWT for the NHS.

← Platelet rich plasma found to be of no benefit in treating torn Achilles tendon
Researchers identify markers in joint fluid that could be key to cartilage repair →

Other news

News Categories

News by Month

See all news

Subscribe to the Oxford BRC Newsletter

Keep informed about the work of the Oxford BRC by subscribing to our Mailchimp e-newsletter. It is produced several times a year and delivers news and information about upcoming events straight to your inbox.

Subscribe Now

Feedback

We’d love to hear your feedback. Please contact us at [email protected]

Oxford BRC on Social Media

  • Bluesky
  • Facebook
  • LinkedIn
  • Threads
  • Twitter
  • YouTube
  • Data Control and Privacy
  • Accessibility
  • Our Partners
  • Disclaimer
  • Contact

Copyright © 2025 NIHR Oxford Biomedical Research Centre