Patients in the UK who have survived critical illnesses requiring care in an intensive care unit (ICU) frequently report symptoms of anxiety, PTSD and/or depression.
Researchers at the University of Oxford investigated psychological disorders in a cohort of 4,943 former ICU patients. They found that 46% of patients reported symptoms of anxiety, 40% symptoms of depression and 22% PTSD, while 18% of patients in the study reported symptoms of all three psychological conditions.
The researchers, who were supported by the NIHR Oxford Biomedical Research Centre (BRC), found that those reporting symptoms of depression after critical illness appeared to be at a greater risk of death.
The study was published in the open access journal, Critical Care, on 20 November.
Corresponding author Dr Peter Watkinson, of the university’s Nuffield Department of Clinical Neurosciences, said: “Psychological problems after being treated for a critical illness in the ICU are very common and often complex when they occur. When symptoms of one psychological disorder are present, there is a 65% chance they will co-occur with symptoms of another psychological disorder.”
To investigate possible links between treatment in an ICU and symptoms of psychological disorders, the authors asked a total of 4,943 patients who received treatment in one of 26 ICUs in the UK between 2006 and 2013, to complete a questionnaire on their symptoms of anxiety, depression and PTSD three months after discharge from ICU and again 12 months after discharge.
The authors found that patients who reported symptoms of depression were 47% more likely to die from any cause (all-cause mortality) during the first two years after discharge from the ICU than those who did not report these symptoms.
Dr Watkinson, who is the Oxford BRC’s Co-theme Lead for Technology and Digital Health, said: “Our findings suggest that depression following care of a critical illness in the ICU may be a marker of declining health and clinicians should consider this when following up with former ICU patients.”
The authors caution that the generalisability of the results outside of the UK may be limited as the data was only collected from UK based patients.
Furthermore, the observational nature of the study and its reliance of self-reported data mean that it does not allow for conclusions about cause and effect between ICU care and symptoms of psychological disorders.