The Molecular Diagnostics Theme aims to deliver true precision medicine for NHS patients by improving the detection, monitoring, and treatment of disease. The Molecular Diagnostics Theme is focused on improving medicine by better classification of disease, allowing more accurate prediction of patients’ prognosis and better prediction of how they will respond to different treatments. This will help to offer the most suitable treatments to patients with cancer and other diseases.
Our focus is predominantly on cancer and it is divided into different areas of research:
- Sub-theme 1: Cancer Genomics for Patient Benefit – Dr David Wedge
- Sub-theme 2: Predicting disease progression – Professor James East
- Sub-theme 3: Precision Biomarkers – Dr David Church
- Sub-theme 4: Experimental Pathology – Professor Clare Verrill
Introductory video about Molecular Diagnostics by Theme Lead, Professor Paresh Vyas
Cancer genomics and immunology seminar
The Molecular Diagnostics theme hosted a very successful seminar, ‘Advanced personalised therapies in gynaecological cancers’, at St Hugh’s College in February 2020. The meeting covered the genomics and immunology of cancer along with the emerging topic of advanced therapeutic medicinal products (ATMPs) in this setting. Speakers included Peter Cambell (Wellcome Sanger Institute) with a keynote lecture by James Brenton (CRUK Cambridge Institute), and co-chairs included Genomics England Clinical Interpretation Partnership – Endometrial Cancer Patient Representative, Helen White. The meeting was well attended by more than 100 delegates, including students, postdoctoral scientists, group leaders, physicians, surgeons and research nurses from Oxford University Hospitals NHS Foundation Trust.
The Vincenzo Cerundolo prize in Cancer Immunology was won by Rui Ma, for his presentation entitled ‘Playing hide and seek with glioblastoma: Using epigenetic modulators to increase cancer testis and neoantigen expression’. The panel discussions and questions were notable for their lively debate, and will hopefully serve as a catalyst for new collaborations and research projects within and outside this field.
Spotlight on Anna Schuh – Associate Professor
Director of Molecular Diagnostics, PI of early diagnosis studies in the UK, Uganda and Tanzania
National Roles: GeCIP Lead for Haematological Malignancies and Chair of NCRI CLL Subgroup
Follow Anna’s work: