UK Biobank is one of the largest ever population-based health studies, recording a wide range of demographic, clinical and genetic data on over 500,000 participants. The UK Biobank Imaging Study is obtaining multiorgan MRI imaging (brain, heart, abdomen) in 100,000 of these subjects.
This project leverages this multi-organ MRI imaging of brain, heart and liver to examine relationships between some of the most common ageing-related conditions, such as degenerative brain disease, heart disease and fatty liver disease.
The aim is to develop composite quantitative heart-liver-brain indices that correlate with clinical status and predict outcomes more powerfully than single-organ based risk markers, thereby developing novel risk prediction models for heart, liver and brain disease, informing disease prevention and risk stratification strategies for these key health conditions.
Stefan Neubauer, Oxford Centre for Clinical Magnetic Resonance Research