Changes in the way we turn the food we eat into the energy we need to survive (metabolism) may be a cause, as well as a consequence, of many human diseases. Magnetic Resonance Imaging (MRI) offers a safe and non-invasive way to study metabolism, but routine clinical application has always been limited by an inherently low sensitivity, i.e. a very weak signal. We are developing a range of new imaging approaches, collectively called Hyperpolarized Magnetic Resonance, that can increase the sensitivity of MRI by more than10,000-fold, offering new clinical tools for the assessment of metabolism in diseases such as heart disease, cancer and stroke.
Damian Tyler and Stefan Neubauer
Department of Physiology, Anatomy and Genetics, and Oxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine