NIHR Oxford Biomedical Research Centre

Enabling translational research through partnership

MENUMENU
  • About
    • About the NIHR Oxford Biomedical Research Centre
    • A Guide to What We Do
    • Activities during COVID-19
    • Strategic Partnership Board
    • Steering Committee
    • Promoting Equality, Diversity and Inclusion in Research
    • Current Vacancies
    • Contact Us
    • Stay in Touch
  • Research
        • OUR 20 RESEARCH THEMES

        • Antimicrobial Resistance and Modernising Microbiology
        • Cardiovascular
        • Clinical Informatics and Big Data
        • Diabetes and Metabolism
        • Gastroenterology and Mucosal Immunity
        • Genomic Medicine
        • Haematology and Stem Cells
        • Imaging
        • Molecular Diagnostics
        • Multi-Modal Cancer Therapies
        • Multi-Morbidity and Long-Term Conditions
        • Musculoskeletal
        • Neurological Conditions
        • Obesity, Diet and Lifestyle
        • Partnerships for Health, Wealth and Innovation
        • Respiratory
        • Stroke and Vascular Dementia
        • Surgical Innovation and Evaluation
        • Technology and Digital Health
        • Vaccines for Emerging and Endemic Diseases
        • Oxford Biomedical Research Centre activities during COVID-19
  • Patient & Public Involvement
    • Getting involved with research
    • Researcher Guidance
    • Post an opportunity for patient and public involvement
  • Training Hub
    • Training Hub Overview
    • Clinical Academic Pathway
    • Internships
    • Preparatory Research Fellowships
    • Senior Research Fellowships
    • Research Training Bursaries
    • Doctoral Awards
    • Post-Doctoral Awards
    • Other funding
    • Leadership Training
    • Useful Links
    • Training and Education Resources
    • Upcoming Training Events & Courses
  • Industry
    • Collaborate with Oxford BRC
    • What Can We Do For Your Organisation?
    • Who Do We Work With?
    • IP and Licensing
    • Contacts for Industry
  • Videos
  • News
  • Events
Research Theme

Imaging

You are here: Home > Research Themes > Imaging > Sub-theme: Hyperpolarised Xenon Imaging (HPX)

Sub-theme: Hyperpolarised Xenon Imaging (HPX)

Objective: to investigate the use of hyperpolarised xenon imaging in respiratory disease.

HPX image
HPX image

The Oxford Hyperpolarised Xenon Imaging Group has been involved in research using Hyperpolarised xenon (HPX) imaging  for seven years. HPX imaging is a novel method using MRI and xenon gas to image the lungs, providing structural and functional information without exposing the patient to ionising radiation.

HPX provides ventilation and apparent diffusion co-efficient maps and quantification values, and also dissolved phase imaging – the visualisation and quantification of gas crossing the alveolar membrane and interstitial into the pulmonary capillary plasma and red blood cells.  We have developed analysis techniques that enable lung function to be assessed at a lobar level and this may be of value in patients with impaired lung function referred for thoracic surgery.

Xenon MRI Research Programme – Groundbreaking Lung Imaging

Future research aims to:

  • improve the identification and analysis of collateral ventilation in patients with severe emphysema being considered for endobronchial valve treatment or lung volume reduction surgery;
  • provide a quantitative imaging technique in patients with interstitial lung disease;
  • improve quantitative imaging in patients with airways disease.

Fergus Gleeson
Fergus Gleeson

Sub-theme leads

Fergus Gleeson, with T Matin, O Doganay

Radiology Department
Cancer and Diagnostic Centre
Churchill Hospital Campus
Oxford University hospitals NHS Foundation Trust

Contact: fgleeson@mac.com

Imaging Theme

  • Introduction
  • Sub-theme: Cardiac tissue characterisation with MRI
  • Sub-theme: Computer guided endoscopy for precancerous change in the oesophagus
  • Sub-theme: Development of novel MRI measures of tissue health
  • Sub-theme: Economic and policy considerations of novel imaging techniques
  • Sub-theme: Efficient scanning using cardiovascular computed tomography
  • Sub-theme: Hyperpolarized Magnetic Resonance – making clearer pictures
  • Sub-theme: Hyperpolarised Xenon Imaging (HPX)
  • Sub-theme: Improving the diagnostic quality of ultrasound
  • Sub-theme: Quantitative MRI in hepatopancreaticobiliary (HPB) imaging
  • Sub-theme: Standardisation of new cardiac MRI mapping techniques for immediate clinical applications
  • Sub-theme: Modelling the heart-brain-liver axis via multi-organ MRI in UK Biobank
  • Contacts
  • Videos for this theme
  • News for this theme

Subscribe to the Oxford BRC Newsletter

Keep informed about the work of the Oxford BRC by subscribing to our Mailchimp e-newsletter. It is produced several times a year and delivers news and information about upcoming events straight to your inbox.

Subscribe Now

Oxford BRC on Social Media

  • Facebook
  • LinkedIn
  • Twitter
  • YouTube

Feedback

We’d love to hear your feedback. Please contact us at obrcenquiries@ouh.nhs.uk

  • Sitemap
  • Data Control and Privacy
  • Accessibility
  • Our Partners
  • Disclaimer
  • Contact

Copyright © 2022 NIHR Oxford Biomedical Research Centre