Objective: to investigate the use of hyperpolarised xenon imaging in respiratory disease.
The Oxford Hyperpolarised Xenon Imaging Group has been involved in research using Hyperpolarised xenon (HPX) imaging for seven years. HPX imaging is a novel method using MRI and xenon gas to image the lungs, providing structural and functional information without exposing the patient to ionising radiation.
HPX provides ventilation and apparent diffusion co-efficient maps and quantification values, and also dissolved phase imaging – the visualisation and quantification of gas crossing the alveolar membrane and interstitial into the pulmonary capillary plasma and red blood cells. We have developed analysis techniques that enable lung function to be assessed at a lobar level and this may be of value in patients with impaired lung function referred for thoracic surgery.
Xenon MRI Research Programme – Groundbreaking Lung Imaging
Future research aims to:
- improve the identification and analysis of collateral ventilation in patients with severe emphysema being considered for endobronchial valve treatment or lung volume reduction surgery;
- provide a quantitative imaging technique in patients with interstitial lung disease;
- improve quantitative imaging in patients with airways disease.
Fergus Gleeson, with T Matin, O Doganay
Cancer and Diagnostic Centre
Churchill Hospital Campus
Oxford University hospitals NHS Foundation Trust