NIHR Oxford Biomedical Research Centre

Enabling translational research through partnership

MENUMENU
  • About
    • About the NIHR Oxford Biomedical Research Centre
    • A Guide to What We Do
    • Activities during COVID-19
    • Strategic Partnership Board
    • Steering Committee
    • Promoting Equality, Diversity and Inclusion in Research
    • Current Vacancies
    • Contact Us
    • Stay in Touch
  • Research
        • OUR 20 RESEARCH THEMES

        • Antimicrobial Resistance and Modernising Microbiology
        • Cardiovascular
        • Clinical Informatics and Big Data
        • Diabetes and Metabolism
        • Gastroenterology and Mucosal Immunity
        • Genomic Medicine
        • Haematology and Stem Cells
        • Imaging
        • Molecular Diagnostics
        • Multi-Modal Cancer Therapies
        • Multi-Morbidity and Long-Term Conditions
        • Musculoskeletal
        • Neurological Conditions
        • Obesity, Diet and Lifestyle
        • Partnerships for Health, Wealth and Innovation
        • Respiratory
        • Stroke and Vascular Dementia
        • Surgical Innovation and Evaluation
        • Technology and Digital Health
        • Vaccines for Emerging and Endemic Diseases
        • Oxford Biomedical Research Centre activities during COVID-19
  • Patient & Public Involvement
    • About Patient and Public Involvement
      • Our Work with Patients and the Public
      • Learn More About Our Research
      • Patient Involvement Blog
      • External Links
    • For Patients, Carers and the Public
      • Current Listings for Involvement
      • REGISTER INTEREST
      • Patient and Public Involvement Workshops
    • PPI Resources for Researchers
      • PPI Strategy
      • A Researcher’s Guide to PPI
      • PPI Resources for Researchers
      • PPI Briefing Notes
      • PPI Case Studies
      • PPI Advisory Group
      • PPI Events for Researchers
      • Post a PPI Listing
      • Public Engagement for Researchers
      • Public Engagement Case Studies
  • Training Hub
    • Training Hub
    • Fellowships
    • Funding Opportunities
    • Clinical Researchers and Scientists
    • Nurses, Midwives and Allied Health Professionals
    • Next Generation Leaders Programme
    • Useful Links
    • Training and Education Resources
    • Upcoming Training Events & Courses
  • Industry
    • Collaborate with Oxford BRC
    • What Can We Do For Your Organisation?
    • Who Do We Work With?
    • IP and Licensing
    • Contacts for Industry
  • Videos
  • News
  • Events
Research Theme

Gastroenterology and Mucosal Immunity

You are here: Home > Research Themes > Gastroenterology and Mucosal Immunity > Sub-theme 2: Biomarker and drug target development

Sub-theme 2: Biomarker and drug target development

Sub-theme leads: Fiona Powrie and Alison Simmons

A major aim of this sub-theme is to develop approaches to integrate patient clinical data with experimental datasets obtained from sub-theme 1. We have established a multi-parameter database linking clinical, biochemistry, haematology and immune phenotyping datasets with deep genotyping within the Oxford IBD cohort. Through application of sophisticated algorithms we have identified genetic associations with specific biological and clinical outcomes. In collaboration with the BRC Technology and Digital Health and cross-cutting Clinical Informatics themes, we are now scaling up this approach to incorporate additional longitudinal clinical data, as well as information from different types of inflammatory disease. In collaboration with the Structural Genomics Consortium and Target Discovery Institute we are also screening existing and new compounds for their ability to correct defective pathways and validating potential improved biomarkers.

Prof Fiona Powrie

Read more about Prof Powrie’s research group

 

 

Prof Alison Simmons

Read more about Prof Simmons’s research

 

Gastroenterology and Mucosal Immunity Theme

  • Introduction
  • Sub-theme 1: Molecular pathway analysis
  • Sub-theme 2: Biomarker and drug target development
  • Sub-theme 3: Experimental medicine trials
  • Projects awarded with response mode funds
  • Principal investigators
  • Constituent research institutes
  • Contacts
  • Videos for this theme
  • News for this theme

Subscribe to the Oxford BRC Newsletter

Keep informed about the work of the Oxford BRC by subscribing to our Mailchimp e-newsletter. It is produced bimonthly and delivers news and information about upcoming events straight to your inbox.

Subscribe Now

Oxford BRC on Social Media

  • Facebook
  • Twitter
  • YouTube

Feedback

We’d love to hear your feedback. Please contact us at obrcenquiries@ouh.nhs.uk

  • Sitemap
  • Data Control and Privacy
  • Accessibility
  • Our Partners
  • Disclaimer
  • Contact

Copyright © 2021 NIHR Oxford Biomedical Research Centre

Cookies

This site uses cookies See our data control and privacy page