Sub-theme leads: Paul Klenerman and Holm Uhlig
We have developed proteomic and genomic approaches including whole exome sequencing, single cell RNA sequencing and flow and mass cytometry for high parameter analysis of small numbers of cells from tissue sites and blood. By combining immune phenotyping with molecular technologies capable of deconvoluting tissue signatures of inflammation, we aim to redefine inflammatory GI and skin disease based on unique and common disease drivers. This will guide the development of new therapeutic approaches or opportunities to re-purpose existing drugs. Patients are recruited by the Translational Gastroenterology Unit Biobank.
Prof Paul Klenerman
Read more about Prof Klenerman’s research group
Prof Holm Uhlig