NIHR Oxford Biomedical Research Centre

Enabling translational research through partnership

MENUMENU
  • About
    • About the NIHR Oxford Biomedical Research Centre
    • A Guide to What We Do
    • Activities during COVID-19
    • Strategic Partnership Board
    • Steering Committee
    • Promoting Equality, Diversity and Inclusion in Research
    • Current Vacancies
    • Contact Us
    • Stay in Touch
  • Research
        • OUR 20 RESEARCH THEMES

        • Antimicrobial Resistance and Modernising Microbiology
        • Cardiovascular
        • Clinical Informatics and Big Data
        • Diabetes and Metabolism
        • Gastroenterology and Mucosal Immunity
        • Genomic Medicine
        • Haematology and Stem Cells
        • Imaging
        • Molecular Diagnostics
        • Multi-Modal Cancer Therapies
        • Multi-Morbidity and Long-Term Conditions
        • Musculoskeletal
        • Neurological Conditions
        • Obesity, Diet and Lifestyle
        • Partnerships for Health, Wealth and Innovation
        • Respiratory
        • Stroke and Vascular Dementia
        • Surgical Innovation and Evaluation
        • Technology and Digital Health
        • Vaccines for Emerging and Endemic Diseases
        • Oxford Biomedical Research Centre activities during COVID-19
  • Patient & Public Involvement
    • Getting involved with research
    • Researcher Guidance
    • Post an opportunity for patient and public involvement
  • Training Hub
    • Training Hub Overview
    • Clinical Academic Pathway
    • Internships
    • Preparatory Research Fellowships
    • Senior Research Fellowships
    • Research Training Bursaries
    • Doctoral Awards
    • Post-Doctoral Awards
    • Other funding
    • Leadership Training
    • Useful Links
    • Training and Education Resources
    • Upcoming Training Events & Courses
  • Industry
    • Collaborate with Oxford BRC
    • What Can We Do For Your Organisation?
    • Who Do We Work With?
    • IP and Licensing
    • Contacts for Industry
  • Videos
  • News
  • Events
Research Theme

Diabetes and Metabolism

You are here: Home > Research Themes > Diabetes and Metabolism > Sub-Theme: Translational Physiology, Therapeutics and Medical Innovation

Sub-Theme: Translational Physiology, Therapeutics and Medical Innovation

Clinical studies in patients and healthy volunteers help us not only to understand the mechanisms that drive the development of diabetes and metabolic disease, but can begin to help us identify new targets that can lead to the development of novel drug therapies.

Our studies are performed in adults and children and their aim is to characterise metabolic dysfunction and how this relates to the production and action of insulin as well as the function of fat tissue and the liver. Our studies are performed on the BRC-supported Clinical Research Unit that allows us to carry out in-depth assessments and investigations in human subjects. The studies that we perform will allow us to define how genetic differences between individuals result in increased (or decreased) risk of diabetes (type 1 and type 2), and also of the complications of diabetes. Understanding how these genetic signals translate into risk of disease can provide valuable clues that point towards as yet unexplored approaches that will translate into new ways of predicting, preventing and treating diabetes and its consequences.

Some researchers in our subtheme plan to use immune therapy as a strategy to treat patients with type 1 diabetes, whilst others are focused on characterising the processes that can drive fat accumulation in the liver, and testing new strategies that aim to offer an effective treatment for diabetes-associated liver disease. In addition, we will use eHealth applications to provide a more joined up approach between community and hospital-based monitoring of diseases including diabetes with the aim of improving patient care.

LINKS:
AMP T2D Genetics portal: http://www.type2diabetesgenetics.org


Jeremy Tomlinson

Sub-Theme Leader: Jeremy Tomlinson

Key Researchers: Fredrik Karpe, Jeremy Tomlinson, Katharine Owen, Rachel Besser, Leanne Hodson, Amanda Adler

Diabetes and Metabolism Theme

  • Introduction
  • Sub-Theme: Translational Physiology, Therapeutics and Medical Innovation
  • Sub-Theme: Translational Islet and Metabolic Tissue Biology
  • Sub-Theme: Pancreas and Islet Cell Transplantation
  • Sub-Theme: Service Innovation and Evaluation
  • Clinical Research Unit / Clinical Investigation Unit
  • Diabetes and Metabolism Core Labs
  • Oxford BioResource
  • Patient involvement with the Diabetes and Metabolism theme
  • Contacts
  • Videos for this theme
  • News for this theme
  • Diabetes & Metabolism Summer Studentship Scheme

Subscribe to the Oxford BRC Newsletter

Keep informed about the work of the Oxford BRC by subscribing to our Mailchimp e-newsletter. It is produced several times a year and delivers news and information about upcoming events straight to your inbox.

Subscribe Now

Oxford BRC on Social Media

  • Facebook
  • LinkedIn
  • Twitter
  • YouTube

Feedback

We’d love to hear your feedback. Please contact us at obrcenquiries@ouh.nhs.uk

  • Sitemap
  • Data Control and Privacy
  • Accessibility
  • Our Partners
  • Disclaimer
  • Contact

Copyright © 2022 NIHR Oxford Biomedical Research Centre