Translational research involves the acquisition and analysis of data from the point of care. This can be expensive, time consuming and error prone. The clinical informatics and big data theme exists to reduce the costs of data, and hence increase the scalability, reproducibility and impact of translational research.
The immediate objectives of the theme include:
- the establishment of a comprehensive, catalogued data warehouse for Oxford University Hospitals NHS Foundation Trust
- the creation of data products for key therapeutic areas, in collaboration with colleagues from BRC scientific themes
- the delivery of an appropriate governance framework for data processing and re-use across the university-hospital partnership
The key therapeutic areas addressed include: cancer, diabetes, cardiovascular, infection, gastroenterology, transplantation and critical care.
Subsequent objectives include:
- the establishment of a secure, cloud-based research data platform for the university-hospital partnership
- the development of algorithms for research data abstraction and phenotyping in key therapeutic areas, in collaboration with colleagues from scientific themes
- the delivery of research outputs enabled by this new informatics infrastructure, again in collaboration with colleagues from scientific themes
The theme is closely linked to the NIHR Health Informatics Collaborative, which is working to improve the quality and availability of data for translational research across the entire network for 20 NIHR BRCs. Oxford is the coordinating centre for the Collaborative, and is engaged in cross-BRC collaborations in several therapeutic areas, including cancer, cardiovascular, transplantation, infection and critical care.
The clinical informatics and big data team are based in the Oxford Big Data Institute (BDI), which acts as a focus for interdisciplinary collaboration in health data science.