We are seeking to involve people living with multiple joints affected by osteoarthritis. E.g. A person who got a first diagnosis of osteoarthritis in the hand and years later a new diagnosis of osteoarthritis in the knee.
Other example: a person who started with a diagnosis of osteoarthritis in the hip and after that was diagnosed with a generalised osteoarthritis in other regions of her/his body.
We are looking for people aged 45 or more.
Both sexes are welcome bearing in mind osteoarthritis is more common in women.
We are looking between 5 to 10 participants. They would complete some questionnaires to help in the study design. They would select relevant outcomes to them from a list.
About the study:
Multi-site osteoarthritis has been shown to be associated with more severe pain and worse health-related quality of life compared to single-site osteoarthritis. Therefore, the identification of progression to multi-site osteoarthritis will help clinicians to delineate subgroups of osteoarthritis patients that will benefit from a specific treatment and prevention strategies.
In this study, we will use the QResearch database of patients in primary care. This is the largest general practice research database in the UK, and it contains over 35 million patients ever registered with 7,500 general practices.
We will identify patients with a first diagnosis of osteoarthritis in one site (the back, shoulder, wrist, hand, hip, knee, ankle, or foot), then identify later osteoarthritis diagnoses in other sites over time (secondary diagnoses). We will classify these patients into predetermined subgroups by whether and how their osteoarthritis progressed from that first site to other joint sites. We will then aim to define patient groups with different characteristics using a wide variety of demographic, life-style and clinical factors.
The deadline for the submission of the first stage of the grant application will be 11 November 2020. If the grant is successful we will be able to cover PPI costs around September 2021.
University of Oxford/Nuffield Department of Primary Care Health Sciences
Cesar Garriga, PhD
Nuffield Department of Primary Care Health Sciences,
University of Oxford,
Radcliffe Observatory Quarter,
Oxford OX2 6GG