Immunity and Inflammation — Introduction

Immunity and Infection theme investigators are developing immunological monitoring tools to predict prognosis and therapeutic response to novel agents in autoimmune diseases including rheumatoid arthritis and ankylosing spondylitis; skin diseases including psoriasis and atopic dermatitis; immunodeficiency syndromes; and chronic viral infection.

We are also developing immunotherapy for HIV-1 and HCV infection (in collaboration with vaccines and cohorts themes) using novel therapeutic vaccines.

Translational Immunology Laboratory

A newly established Translational Immunology Laboratory (TIL) provides scientific and technical support for the Immunity and Inflammation theme and other BRC projects.

The Translational Immunology Lab (TIL), based on Level 5 of the John Radcliffe Hospital, provides technical and scientific support for any flow cytometry needs. We have three flow cytometers that can provide a wide range of techniques, from 4-colour up to 15-colour multi-parametric flow cytometry. We also offer access to an ImageStream cytometer, which can provide quantitative imaging and a wide range of applications, including: cell signaling, co-localization, shape change, internalization, and more.

Our machines are located within the NDM flow facility, also located on Level 5 of the John Radcliffe Hospital. The facility, run by Helen Ferry, also offers a cell sorting service.

The TIL can assist in designing, setting up and testing multi-antibody panels. We provide training on all our cytometers. We can also provide support with flow cytometer data analysis using FlowJo software.

If you need help putting together an antibody panel, or have difficulty analysing your data, we will do our best to assist. Please email Chris Willberg if you would like to discuss this further.

A list of protocols and antibody panels currently being developed within the lab are published regularly online.