Diabetes — Introduction

The Diabetes Theme is broad based and its overarching objective is to improve life and patient-important outcomes for people with diabetes mellitus by addressing many aspects of this complex, diverse, common, debilitating and costly condition.

There are three main areas of research in the Diabetes theme:

Translational Genetics and Genomics Group (TGGG)

The overarching aim of the TGGG is to translate recent and future advances in type 2 diabetes genetics and the genomics of islet regulation into improvements in clinical management and outcome.

Translational Physiology Group (TPG)

The TPG aims to better understand glucose homeostasis, the abnormalities in diabetes and to develop novel methods of monitoring, improving and replacing islet function from the individual islet to the whole pancreas.

Translational Trials Group (TTG)

The TTG actively seeks out novel therapeutic opportunities and devices from academia and industry, undertakes robust evaluations of their potential risks, benefits and likelihood of success and, where appropriate, performs first-in-man (or patient) proof-of-concept randomised controlled trials

Underpinning and supporting these three programmes are the DWRF Islet Isolation Facility, the Pancreas Whole Organ and Islet Transplantation Programmes and the OCDEM Clinical Research Unit (see below).


OCDEM Clinical Research Unit

The Clinical Research Unit (CRU) is the hub of activity for translational research within the Oxford Centre for Diabetes, Endocrinology and Metabolism, (OCDEM). Resources in the unit include 8 beds with facilities for overnight stays, a DEXA scanner, and a fully resourced laboratory.  We also have a fully equipped room to support metabolism studies including ultrasound, use of stable isotope and other equipment facilitating the measurement of a wide range of metabolic profiles.

The CRU led by a Clinical Director, Professor Fredrik Karpe and staffed by a full time manager and 8 research nurses.  Currently a total of 45 studies are registered with the unit which cover a wide spectrum of research areas across diabetes, endocrinology and lipid metabolism.

The unit provides support to both academic and commercially based studies and provides a safe and comfortable patient environment with a high level of experience and support for the researcher