Cardiovascular — Sub-theme 5: Vascular Surgery

Sub-theme leads: Prof Alison Halliday

With the recruitment of Alison Halliday as Professor of Vascular Surgery, we have added this sub-theme to the Cardiovascular Theme.

Translational clinical research and on cooperating in atherosclerotic imaging research studies within the Cardiovascular theme. A large multinational randomized trial (ACST-2, the Asymptomatic Carotid Surgery Trial-2) is comparing the outcomes (hazards and long-term benefits) of surgery (carotid endarterectomy) and stenting (carotid artery stenting) for patients with severe atherosclerotic narrowing of the carotid artery who are thought to be at high risk of stroke, but have not had any stroke-like symptoms for at least 6 months. Over 1000 patients from 24 countries have already been recruited.

Vascular arterial surgery involves open repair of enlarged or ruptured vessels as well as bypass or removal of atherosclerosis when arteries are narrowed or occluded. By using the Acute Vascular Imaging Centre (AVIC) imaging to focus on mechanisms causing arterial weakness and rupture in Aortic Aneurysm, we can help develop new treatments to prevent rupture and death. By imaging the effects of carotid stenting and surgery on brain cell function we can reduce risk from intervention and prevent stroke.

Relevance of research to the health of patients and the public: The need for less invasive procedures to prevent stroke has clear benefits for patients, by reducing the need for general anaesthesia and shortening hospital stay. For patients awaiting coronary bypass grafting, there is the potential benefit of reducing the stroke risk from bypass surgery by stenting severe carotid stenosis beforehand.